Results 81 to 90 of about 7,574,392 (244)

Influence of continuous electrical stimulation on development of human cardiomyocytes from induced pluripotent stem cells [PDF]

, 2018
Regeneration of cardiac tissue remains an ideal approach to restore cardiac function after myocardial infarction. The ability of human induced pluripotent stem cells (iPSCs) to differentiate into bona fide cardiomyocytes also provides a platform for ...
Hernández, D, Millard, R, Pebay, A, Lim, S, Kong, A, Sivakumaran, P, Sheperd, R, Mitchell, G, Dusting, G   +8 more
core   +1 more source

Cardiomyocytes derived from embryonic stem cells resemble cardiomyocytes of the embryonic heart tube

, 2003
OBJECTIVE: After formation of the linear heart tube a chamber-specific program of gene expression becomes active that underlies the formation of the chamber myocardium.
Fijnvandraat, Arnoud C., van Ginneken, Antoni C. G., Lekanne Deprez, Ronald H., Christoffels, Vincent M., Ruijter, Jan M., Moorman, Antoon F. M., de Boer, Piet A. J.   +6 more
core   +1 more source

Empagliflozin inhibits Na + /H + exchanger activity in human atrial cardiomyocytes [PDF]

, 2020
Aims Recent clinical trials have proven gliflozins to be cardioprotective in diabetic and non-diabetic patients. However, the underlying mechanisms are incompletely understood.
Lebek, Simon, Sossalla, Samuel T., Riechel, Johannes, Wagner, Stefan, Arzt, Michael, Maier, Lars S., Trum, Maximilian, Pabel, Steffen, Hirt, Stephan   +8 more
core   +1 more source

QRICH1 Disrupts Endoplasmic Reticulum Homeostasis and Amplifies NF‐κB Signaling in Periodontal Ligament Stem Cells to Exacerbate Diabetic Periodontitis

Advanced Science, EarlyView.
QRICH1 has been established as a key factor contributing to impaired osteogenic potential and accelerated apoptosis of PDLSCs in diabetic periodontitis. QRICH1 not only significantly enhances UPR‐associated apoptotic signaling but also amplifies NF‐κB‐mediated inflammatory responses. Its inhibition restores osteogenic capacity and reduces alveolar bone
Han Li, Xiaoyu Yang, He Wang, Yunchun Kuang, Yiyao Hu, Houxuan Li, Shuhong Li, Deping Zeng, Jie Li, Jinlin Song   +9 more
wiley   +1 more source

A Novel Pak1 Activator Ameliorates ER Stress for HFpEF Therapy

Advanced Science, EarlyView.
Chronic metabolic stress is a major contributor to HFpEF progression. Under prolonged metabolic stress, Pak1 activity becomes impaired, contributing to disrupted ER proteostasis, cardiomyocyte apoptosis, fibrosis, and diastolic dysfunction. Mechanistically, Pak1 overexpression activates the ERK1/2–MNK1–eIF4E signaling axis, promotes translational ...
Honglin Xu, Hongyuan Zhang, Tayyiba Azam, Susanne S. Hille, Yingjuan Liu, Min Zi, Jiaqing Lang, He Yu, Yujia Cao, Bernard D. Keavney, Tamer M. A. Mohamed, Jessica M. Miller, Riham R. E. Abouleisa, Ming Xu, Elizabeth J. Cartwright, Oliver J. Müller, Ming Lei, Xin Wang   +17 more
wiley   +1 more source

Programmable Paracrine‐Mimetic Microneedle System for Temporal Regulation of Cardiac Repair

Advanced Science, EarlyView.
Temporal signaling is encoded into a programmable paracrine‐mimetic microneedle patch via tris(2,2'‐bipyridyl)dichlororuthenium(II) hexahydrate/sodium persulfate‐tuned hydrogel microparticles that deliver TGF‐β, IGF‐1, and VEGF over phase‐matched 7‐, 14‐, and 28‐day windows.
Yichen Dai, Pengchong Du, Zhaoyang Wang, Surilige, Rangga Fokta, Renjian Tan, Xiqing Zhao, Shuoyi Zhang, Yuecheng Wang, Yixin Zhang, Ziliang Fu, Rui Gong, Cheng Jiang, Yisheng He, Qiguang Wang, Renke Li, Khoon Lim, Junnan Tang, Xiaolin Cui   +18 more
wiley   +1 more source

Nucleoside‐Modified mRNA Encoding Alpha‐Galactosidase A Ameliorates Fabry Disease Phenotypes in Human IPSC‐Derived Cardiomyocytes

Advanced Science, EarlyView.
Human iPSC‐derived Fabry cardiomyocytes exhibited broad transcriptional dysregulation, apoptosis, mitochondrial dysfunction, impaired reactive oxygen species handling, altered contractility, and abnormal calcium transient decay, potentially mediated by phospholamban hyperphosphorylation.
Malte Juchem, Lea Oehlsen, Sedef Ersoy, Jia Li Ye, Natalie Weber, Elisa Mohr, Wilson Agyapong, Junqing Liu, Maximilian Fuchs, Ke Xiao, Christopher Jahn, Reto Eggenschwiler, Tobias Cantz, Julia Beimdiek, Falk F. R. Buettner, Theresia Kraft, Jan Hegermann, Ivonne J. Knorr, Lisa Ernst, Linda Feldbrügge, Resa Puffert, Kevin Schmidt, Christian Bär, Jeannine Hoepfner, Thomas Thum   +24 more
wiley   +1 more source

Single cardiomyocyte nuclear transcriptomes reveal a lincRNA-regulated de-differentiation and cell cycle stress-response in vivo

Nature Communications, 2017
Adult mammalian cardiomyocytes are predominantly binucleated and unable to divide. Using single nuclear RNA-sequencing of cardiomyocytes from mouse and human failing and non-failing adult hearts, See et al. show that some cardiomyocytes respond to stress
Kelvin See, Wilson L. W. Tan, Eng How Lim, Zenia Tiang, Li Ting Lee, Peter Y. Q. Li, Tuan D. A. Luu, Matthew Ackers-Johnson, Roger S. Foo   +8 more
doaj   +1 more source

Effects of Met on Dox induced cytotoxicity in RL-14 human cardiomyocytes and rat primary cardiomyocytes.

, 2014
RL-14 human immortalized fetal cardiomyocytes and rat neonatal primary cardiomyocytes (Rat CM) were cultured with same conditions as we did for H9c2 cells, and (A) cell viabilities, (B) LDH leakages, (C) ROS generations and (D) [Ca2+]i were evaluated at ...
Laura C. Kobashigawa (616302), James F. Padbury (173674), Naohiro Yano (173654), Yi-Tang Tseng (341569), Yan Chun Xu (616303)   +4 more
core   +1 more source

The effect of exercise training on transverse tubules in normal, remodeled, and reverse remodeled hearts [PDF]

, 2011
The response of transverse (T)-tubules to exercise training in health and disease remains unclear. Therefore, we studied the effect of exercise training on the density and spacing of left ventricle cardiomyocyte T-tubules in normal and remodeled hearts ...
Kemi, Ole J., Wisloff, Ulrik, Koch, Lauren G., Morten A. Hoydal, MacQuaide, Niall, Haram, Per M., Godfrey L. Smith, Steven L. Britton, Hoydal, Morten A., Smith, Godfrey L., Ellingsen, Oyvind, Per M. Haram, Lauren G. Koch, Oyvind Ellingsen, Britton, Steven L., Niall MacQuaide, Ole J. Kemi, Ulrik Wisloff   +17 more
core   +1 more source