Results 31 to 40 of about 113,516 (292)

Evidence for Cardiomyocyte Renewal in Humans [PDF]

Science, 2009
It has been difficult to establish whether we are limited to the heart muscle cells we are born with or if cardiomyocytes are generated also later in life. We have taken advantage of the integration of carbon-14, generated by nuclear bomb tests during the Cold War, into DNA to establish the age of cardiomyocytes in humans. We report that cardiomyocytes
Bergmann, Olaf, Bhardwaj, Ratan D, Bernard, Samuel, Zdunek, Sofia, Barnabé-Heider, Fanie, Walsh, Stuart, Zupicich, Joel, Alkass, Kanar, Buchholz, Bruce A, Druid, Henrik, Jovinge, Stefan, Frisén, Jonas   +11 more
openaire   +3 more sources

Identification of miRNAs as Biomarkers of Cardiac Protection in Non-Genetically Modified Primary Human Cardiomyocytes Exposed to Halogenated Hypnotics in an In Vitro Model of Transfection and Ischemia/Reperfusion: A New Model in Translational Anesthesia

Life, 2022
Background: Many clinical studies have identified some circulating micro-RNAs (miRNAs) as potential biomarkers with regard to the cardioprotective effects of halogenated agents administered perioperatively during myocardial conditioning procedures ...
Maria Dolores Carmona-Luque, Laura Gonzalez-Alvarez, José Luis Guerrero Orriach   +2 more
doaj   +1 more source

Comparative Effect of MSC Secretome to MSC Co-culture on Cardiomyocyte Gene Expression Under Hypoxic Conditions in vitro

Frontiers in Bioengineering and Biotechnology, 2020
IntroductionDespite major leaps in regenerative medicine, the regeneration of cardiomyocytes after ischemic conditions remains to elucidate. It is crucial to understand hypoxia induced cellular mechanisms to provide advanced treatment options, including ...
Nina Kastner, Julia Mester-Tonczar, Johannes Winkler, Denise Traxler, Andreas Spannbauer, Beate M. Rüger, Georg Goliasch, Noemi Pavo, Mariann Gyöngyösi, Katrin Zlabinger   +9 more
doaj   +1 more source

Empagliflozin and Dapagliflozin Increase Na⁺ and Inward Rectifier K⁺ Current Densities in Human Cardiomyocytes Derived from Induced Pluripotent Stem Cells (hiPSC-CMs)

Cells, 2022
Dapagliflozin (dapa) and empagliflozin (empa) are sodium-glucose cotransporter-2 inhibitors (SGLT2is) that reduce morbidity and mortality in heart failure (HF) patients.
María Dago, Teresa Crespo-García, Anabel Cámara-Checa, Josu Rapún, Marcos Rubio-Alarcón, María Marín, Juan Tamargo, Ricardo Caballero, Eva Delpón   +8 more
doaj   +1 more source

The toxicity of lithium to human cardiomyocytes [PDF]

Environmental Sciences Europe, 2020
Abstract Background: Lithium is widely used in the electronic consumer market and electric vehicles and has a great contribution in the world economy, resulting in large quantities of lithium waste in the environment. Yangtze River basin is one of the most developed areas in China.
Junwei Shen, Xin Li, Xiujuan Shi, Wei Wang, Hua Zhou, Jiawen Wu, Xin Wang, Jue Li   +7 more
openaire   +3 more sources

Cardiomyocytes Derived from Human CardiopoieticAmniotic Fluids [PDF]

Scientific Reports, 2018
AbstractHuman amniotic fluid (hAF) cells share characteristics of both embryonic and adult stem cells. They proliferate rapidly and can differentiate into cells of all embryonic germ layers but do not form teratomas. Embryoid-bodies obtained from hAF have cardiac differentiation potential, but terminal differentiation to cardiomyocytes (CMs) has not ...
Di Baldassarre, Angela, D’Amico, Maria A., Izzicupo, Pascal, Gaggi, Giulia, Guarnieri, Simone, Mariggiò, Maria A., Antonucci, Ivana, Corneo, Barbara, Sirabella, Dario, Stuppia, Liborio, Ghinassi, Barbara   +10 more
openaire   +2 more sources

Single-cell transcriptomic profiling reveals specific maturation signatures in human cardiomyocytes derived from LMNB2-inactivated induced pluripotent stem cells

Frontiers in Cell and Developmental Biology, 2022
Mammalian cardiomyocyte maturation entails phenotypic and functional optimization during the late fetal and postnatal phases of heart development, both processes driven and coordinated by complex gene regulatory networks.
Jie Wang, William Morgan, William Morgan, William Morgan, Ankur Saini, Ankur Saini, Ankur Saini, Tao Liu, John Lough, John Lough, Lu Han, Lu Han, Lu Han   +12 more
doaj   +1 more source

Hypoxia Induces Cardiomyocyte Proliferation in Humans

JACC: Basic to Translational Science, 2020
The mammalian heart has a substantial regenerative capacity in the first few days of life mediated by cardiomyocyte proliferation; however, this capacity is lost shortly after birth ([1][1]). Transition from the embryonic to postnatal circulation results in a rapid and substantial increase in ...
Ahmed, Mahmoud S., Sadek, Hesham A.
openaire   +2 more sources

Live-Cell Imaging of the Contractile Velocity and Transient Intracellular Ca²⁺ Fluctuations in Human Stem Cell-Derived Cardiomyocytes

Cells, 2022
Live-cell imaging techniques are essential for acquiring vital physiological and pathophysiological knowledge to understand and treat heart disease. For live-cell imaging of transient alterations of [Ca2+]i in human cardiomyocytes, we engineered human ...
Aviseka Acharya, Harshal Nemade, Krishna Rajendra Prasad, Khadija Khan, Jürgen Hescheler, Nick Blackburn, Ruth Hemmersbach, Symeon Papadopoulos, Agapios Sachinidis   +8 more
doaj   +1 more source

Reactivation of the mitosis-promoting factor in postmitotic cardiomyocytes [PDF]

, 2003
Cardiomyocytes cease to divide shortly after birth and an irreversible cell cycle arrest is evident accompanied by the downregulation of cyclin-dependent kinase activities.
Datwyler, D. A., Weikert, C., Wightman, L., Magyar, J. P., Hans M. Eppenberger, Wagner, E., Eppenberger, H. M., Josef P. Magyar, Lionel Wightman, Daniel A. Dätwyler, Ernst Wagner, Christian Weikert   +11 more
core   +1 more source