Results 31 to 40 of about 103,809 (257)

Inhibition of miR-128-3p by Tongxinluo Protects Human Cardiomyocytes from Ischemia/reperfusion Injury via Upregulation of p70s6k1/p-p70s6k1

Frontiers in Pharmacology, 2017
Background and Aims: Tongxinluo (TXL) is a multifunctional traditional Chinese medicine that has been widely used to treat cardiovascular and cerebrovascular diseases.
Gui-hao Chen, Chuan-sheng Xu, Jie Zhang, Qing Li, He-he Cui, Xiang-dong Li, Li-ping Chang, Rui-jie Tang, Jun-yan Xu, Xia-qiu Tian, Pei-sen Huang, Jun Xu, Chen Jin, Yue-jin Yang   +13 more
doaj   +1 more source

Electroporation Parameters for Human Cardiomyocyte Ablation In Vitro

Journal of Cardiovascular Development and Disease, 2022
Cardiac ablation with irreversible electroporation (IRE) is quickly being established as a modality of choice for atrial fibrillation treatment. While it has not yet been optimised, IRE has the potential to significantly limit collateral damage and improve cell-specific targeting associated with other energy sources.
Jara M. Baena-Montes, Tony O’Halloran, Cormac Clarke, Kevin Donaghey, Eoghan Dunne, Martin O’Halloran, Leo R. Quinlan   +6 more
openaire   +3 more sources

Vacuolated cardiomyocytes in human endomyocardial biopsy specimens [PDF]

Journal of Cardiology Cases, 2020
We encountered an unfamiliar finding during electron microscopic examination of an endomyocardial biopsy obtained from a 55-year-old woman suffering from heart failure due to dilated phase hypertrophic cardiomyopathy. Many cardiomyocytes contained large vacuoles that were mainly empty except for small amounts of amorphous substrate.
Genzou, Takemura, Kenji, Onoue, Takanori, Arimoto, Tetsu, Watanabe, Akiko, Tsujimoto, Chihiro, Takada, Hideshi, Okada, Tomoya, Nakano, Yasuhiro, Sakaguchi, Nagisa, Miyazaki, Takatomo, Watanabe, Hiromitsu, Kanamori, Shinji, Ogura, Yoshihiko, Saito, Takako, Fujiwara, Hisayoshi, Fujiwara, Yasuaki, Hotta   +16 more
openaire   +2 more sources

The Effect of TWIK-1 Two Pore Potassium Channels on Cardiomyocytes in Low Extracellular Potassium Conditions

Frontiers in Bioscience-Landmark, 2023
Backgroound: At low extracellular potassium ([K+]e) conditions, human cardiomyocytes can depolarize to –40 mV. This is closely related to hypokalemia-induced fatal cardiac arrhythmia. The underlying mechanism, however, is still not well understood.
Ping Liu, Yawen Yang, Hengxi Zhang, Yingying Zhang, Jin Zeng, Dongchuan Zuo   +5 more
doaj   +1 more source

HIV-1 subtype C unproductively infects human cardiomyocytes in vitro and induces apoptosis mitigated by an anti-Gp120 aptamer. [PDF]

PLoS ONE, 2014
HIV-associated cardiomyopathy (HIVCM) is of clinical concern in developing countries because of a high HIV-1 prevalence, especially subtype C, and limited access to highly active antiretroviral therapy (HAART).
Walter R Lopes de Campos, Nthato Chirwa, Grace London, Lia S Rotherham, Lynn Morris, Bongani M Mayosi, Makobetsa Khati   +6 more
doaj   +1 more source

Iron Depletion Affects Genes Encoding Mitochondrial Electron Transport Chain and Genes of Non­Oxidative Metabolism, Pyruvate Kinase and Lactate Dehydrogenase, in Primary Human Cardiac Myocytes Cultured upon Mechanical Stretch

Cells, 2018
(1) Background: Oxidative energy metabolism is presumed to rely on the optimal iron supply. Primary human cardiac myocytes (HCM) exposed to different iron availability conditions during mechanical stretch are anticipated to demonstrate expression changes
Magdalena Dziegala, Kamil A. Kobak, Monika Kasztura, Jacek Bania, Krystian Josiak, Waldemar Banasiak, Piotr Ponikowski, Ewa A. Jankowska   +7 more
doaj   +1 more source

Generation of mature compact ventricular cardiomyocytes from human pluripotent stem cells

Nature Communications, 2021
Cardiomyocytes of heart ventricles consist of subpopulations of trabecular and compact subtypes. Here the authors describe the generation of structurally, metabolically and functionally mature compact ventricular cardiomyocytes as well as mature atrial ...
Shunsuke Funakoshi, Ian Fernandes, Olya Mastikhina, Dan Wilkinson, Thinh Tran, Wahiba Dhahri, Amine Mazine, Donghe Yang, Benjamin Burnett, Jeehoon Lee, Stephanie Protze, Gary D. Bader, Sara S. Nunes, Michael Laflamme, Gordon Keller   +14 more
doaj   +1 more source

In-silico analysis of aging mechanisms of action potential remodeling in human atrial cardiomyocites

BIO Web of Conferences, 2020
Electrophysiology of cardiomyocytes changes with aging. Agerelated ionic remodeling in cardiomyocytes may increase the incidence and prevalence of atrial fibrillation (AF) in the elderly and affect the efficiency of antiarrhythmic drugs.
Nesterova Tatyana, Shmarko Dmitry, Ushenin Konstantin, Solovyova Olga   +3 more
doaj   +1 more source

Engineering human ventricular heart muscles based on a highly efficient system for purification of human pluripotent stem cell-derived ventricular cardiomyocytes

Stem Cell Research & Therapy, 2017
Background Most infarctions occur in the left anterior descending coronary artery and cause myocardium damage of the left ventricle. Although current pluripotent stem cells (PSCs) and directed cardiac differentiation techniques are able to generate fetal-
Bin Li, Hui Yang, Xiaochen Wang, Yongkun Zhan, Wei Sheng, Huanhuan Cai, Haoyang Xin, Qianqian Liang, Ping Zhou, Chao Lu, Ruizhe Qian, Sifeng Chen, Pengyuan Yang, Jianyi Zhang, Weinian Shou, Guoying Huang, Ping Liang, Ning Sun   +17 more
doaj   +1 more source

High-Throughput Drug Screening System Based on Human Induced Pluripotent Stem Cell-Derived Atrial Myocytes ∼ A Novel Platform to Detect Cardiac Toxicity for Atrial Arrhythmias

Frontiers in Pharmacology, 2021
Evaluation of proarrhythmic properties is critical for drug discovery. In particular, QT prolongation in electrocardiograms has been utilized as a surrogate marker in many evaluation systems to assess the risk of torsade de pointes and lethal ventricular
Yayoi Honda, Yayoi Honda, Jun Li, Jun Li, Aya Hino, Shinji Tsujimoto, Jong-Kook Lee   +6 more
doaj   +1 more source