Cells, 2022 Live-cell imaging techniques are essential for acquiring vital physiological and pathophysiological knowledge to understand and treat heart disease. For live-cell imaging of transient alterations of [Ca2+]i in human cardiomyocytes, we engineered human ...
Aviseka Acharya +8 more
doaj +1 more source
Two dimensional electrophysiological characterization of human pluripotent stem cell-derived cardiomyocyte system. [PDF]
, 2017 Stem cell-derived cardiomyocytes provide a promising tool for human developmental biology, regenerative therapies, disease modeling, and drug discovery.
Gimzewski, James K +7 more
core +2 more sources
Rigid microenvironments promote cardiac differentiation of mouse and human embryonic stem cells. [PDF]
, 2013 While adult heart muscle is the least regenerative of tissues, embryonic cardiomyocytes are proliferative, with embryonic stem (ES) cells providing an endless reservoir.
Arshi, Armin +8 more
core +2 more sources
Microtubules increase diastolic stiffness in failing human cardiomyocytes and myocardium
Circulation, 2020 Supplemental Digital Content is available in the text. Background: Diastolic dysfunction is a prevalent and therapeutically intractable feature of heart failure (HF).
M. Caporizzo +4 more
semanticscholar +1 more source
Protein phosphatase 5 regulates titin phosphorylation and function at a sarcomere-associated mechanosensor complex in cardiomyocytes. [PDF]
, 2018 Serine/threonine protein phosphatase 5 (PP5) is ubiquitously expressed in eukaryotic cells; however, its function in cardiomyocytes is unknown. Under basal conditions, PP5 is autoinhibited, but enzymatic activity rises upon binding of specific factors ...
Beckendorf, Lisa +10 more
core +3 more sources
Gap junction reduction in cardiomyocytes following transforming growth factor- beta treatment and Trypanosoma cruzi infection [PDF]
, 2009 Gap junction connexin-43 (Cx43) molecules are responsible for electrical impulse conduction in the heart and are affected by transforming growth factor-beta (TGF-beta).
Becker, D +6 more
core +2 more sources
Yulink, predicted from evolutionary analysis, is involved in cardiac function
Journal of Biomedical Science, 2021 Background The comparative evolutionary genomics analysis was used to study the functions of novel Ka/Ks-predicted human exons in a zebrafish model. The Yulink (MIOS, Entrez Gene: 54,468), a conserved gene from zebrafish to human with WD40 repeats at N ...
Ming-Wei Kuo +5 more
doaj +1 more source
Glucose inhibits cardiac muscle maturation through nucleotide biosynthesis. [PDF]
, 2017 The heart switches its energy substrate from glucose to fatty acids at birth, and maternal hyperglycemia is associated with congenital heart disease. However, little is known about how blood glucose impacts heart formation.
Braas, Daniel +21 more
core +2 more sources
Assessment of Cardiomyocyte Contraction in Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes [PDF]
Toxicological Sciences, 2014 Functional changes to cardiomyocytes are a common cause of attrition in preclinical and clinical drug development. Current approaches to assess cardiomyocyte contractility in vitro are limited to low-throughput methods not amenable to early drug discovery.
Amy, Pointon +6 more
openaire +2 more sources
Stem Cell Reports, 2017 We hypothesized that the neonatal rat heart would bring transplanted human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) to maturity as it grows to adult size.
Shin Kadota +3 more
doaj +1 more source