Results 31 to 40 of about 7,574,392 (244)

Exercise training corrects control of spontaneous calcium waves in hearts from myocardial infarction heart failure rats [PDF]

, 2011
Impaired cardiac control of intracellular diastolic Ca²⁺ gives rise to arrhythmias. Whereas exercise training corrects abnormal cyclic Ca²⁺ handling in heart failure, the effect on diastolic Ca<sup>2 ...
Kemi, Ole J., Wisloff, Ulrik, Morten A. Hoydal, MacQuaide, Niall, Godfrey L. Smith, Hoydal, Morten A., Smith, Godfrey L., Ellingsen, Oyvind, Oyvind Ellingsen, Smith, Godfrey L, Niall MacQuaide, Ole J. Kemi, Ulrik Wisloff   +12 more
core   +1 more source

Iron Depletion Affects Genes Encoding Mitochondrial Electron Transport Chain and Genes of Non­Oxidative Metabolism, Pyruvate Kinase and Lactate Dehydrogenase, in Primary Human Cardiac Myocytes Cultured upon Mechanical Stretch

Cells, 2018
(1) Background: Oxidative energy metabolism is presumed to rely on the optimal iron supply. Primary human cardiac myocytes (HCM) exposed to different iron availability conditions during mechanical stretch are anticipated to demonstrate expression changes
Magdalena Dziegala, Kamil A. Kobak, Monika Kasztura, Jacek Bania, Krystian Josiak, Waldemar Banasiak, Piotr Ponikowski, Ewa A. Jankowska   +7 more
doaj   +1 more source

HIV-1 subtype C unproductively infects human cardiomyocytes in vitro and induces apoptosis mitigated by an anti-Gp120 aptamer. [PDF]

PLoS ONE, 2014
HIV-associated cardiomyopathy (HIVCM) is of clinical concern in developing countries because of a high HIV-1 prevalence, especially subtype C, and limited access to highly active antiretroviral therapy (HAART).
Walter R Lopes de Campos, Nthato Chirwa, Grace London, Lia S Rotherham, Lynn Morris, Bongani M Mayosi, Makobetsa Khati   +6 more
doaj   +1 more source

Generation of mature compact ventricular cardiomyocytes from human pluripotent stem cells

Nature Communications, 2021
Cardiomyocytes of heart ventricles consist of subpopulations of trabecular and compact subtypes. Here the authors describe the generation of structurally, metabolically and functionally mature compact ventricular cardiomyocytes as well as mature atrial ...
Shunsuke Funakoshi, Ian Fernandes, Olya Mastikhina, Dan Wilkinson, Thinh Tran, Wahiba Dhahri, Amine Mazine, Donghe Yang, Benjamin Burnett, Jeehoon Lee, Stephanie Protze, Gary D. Bader, Sara S. Nunes, Michael Laflamme, Gordon Keller   +14 more
doaj   +1 more source

Development and characterization of a scaffold-free 3D spheroid model of iPSC-derived human cardiomyocytes [PDF]

, 2015
Purpose: Cardiomyocytes are terminally differentiated cells in the adult heart and ischemia and cardiotoxic compounds can lead to cell death and irreversible decline of cardiac function.
Beauchamp, Philippe, Anson, Blake, Moritz, Wolfgang, Suter, Thomas, Zuppinger, Christian, Jens, Kelm, Ullrich, Nina, Agarkova, Irina   +7 more
core   +3 more sources

Differentiation of Cardiomyocytes from Human Pluripotent Stem Cells Using Monolayer Culture

, 2015
Human pluripotent stem cells (PSCs) are a promising cell source for cardiac tissue engineering and cell-based therapies for heart repair because they can be expanded in vitro and differentiated into most cardiovascular cell types, including ...
Ivan Batalov, Adam W. Feinberg
core   +1 more source

Preconditioning human cardiomyocytes and endothelial cells [PDF]

, 1998
Background: The effects of simulated “ischemia” and “reperfusion” were evaluated in cell cultures of human ventricular cardiomyocytes and human saphenous vein endothelial cells. Methods: Myocyte and endothelial cell cultures were exposed to a low volume (
Mickle, Donald A., Tumiati, Laura C., Rao, Vivek, Li, Ren-Ke, Shirai, Toshizumi, Weisel, Richard D., Ikonomidis, John S., Merante, Frank   +7 more
core   +1 more source

In-silico analysis of aging mechanisms of action potential remodeling in human atrial cardiomyocites

BIO Web of Conferences, 2020
Electrophysiology of cardiomyocytes changes with aging. Agerelated ionic remodeling in cardiomyocytes may increase the incidence and prevalence of atrial fibrillation (AF) in the elderly and affect the efficiency of antiarrhythmic drugs.
Nesterova Tatyana, Shmarko Dmitry, Ushenin Konstantin, Solovyova Olga   +3 more
doaj   +1 more source

Enhanced nanomagnetic gene transfection of human prenatal cardiac progenitor cells and adult cardiomyocytes [PDF]

, 2013
Magnetic nanoparticle-based gene transfection has been shown to be an effective, non-viral technique for delivery of both plasmid DNA and siRNA into cells in culture.
Jon Dobson, Subramanian, Mahendran, Dobson, John, Mahendran Subramanian, Lim, Jenson, Jenson Lim, Dobson, Jon   +6 more
core   +1 more source

MicroRNA-197-3p Transfection: Variations in Cardiomyocyte Gene Expression with Anaesthetics Drugs in a Model of Hypoxia/Reperfusion

Pharmaceuticals
Background: Our research team analyzed the microRNA (miRNA)-197-3p involved in cardioprotection, and we demonstrated that the overexpression of miRNA-197-3p could be linked to a higher risk of cardiac damage.
Jose Luis Guerrero-Orriach, Maria Dolores Carmona-Luque, Maria Jose Rodriguez-Capitan, Guillermo Quesada-Muñoz   +3 more
doaj   +1 more source