Results 21 to 30 of about 7,574,392 (244)

Effects of local activation times on the tension development of human cardiomyocytes in a computational model

Current Directions in Biomedical Engineering, 2018
The human heart is an organ of high complexity and hence, very challenging to simulate. To calculate the force developed by the human heart and therefore the tension of the muscle fibers, accurate models are necessary.
Müller Armin, Kovacheva Ekaterina, Schuler Steffen, Dössel Olaf, Baron Lukas   +4 more
doaj   +2 more sources

Burst-Like Transcription of Mutant and Wildtype MYH7-Alleles as Possible Origin of Cell-to-Cell Contractile Imbalance in Hypertrophic Cardiomyopathy

Frontiers in Physiology, 2018
Hypertrophic Cardiomyopathy (HCM) has been related to many different mutations in more than 20 different, mostly sarcomeric proteins. While development of the HCM-phenotype is thought to be triggered by the different mutations, a common mechanism remains
Judith Montag, Kathrin Kowalski, Mirza Makul, Pia Ernstberger, Ante Radocaj, Julia Beck, Edgar Becker, Snigdha Tripathi, Britta Keyser, Christian Mühlfeld, Kirsten Wissel, Andreas Pich, Jolanda van der Velden, Cristobal G. dos Remedios, Andreas Perrot, Antonio Francino, Francesco Navarro-López, Bernhard Brenner, Theresia Kraft   +18 more
doaj   +1 more source

Inhibition of miR-128-3p by Tongxinluo Protects Human Cardiomyocytes from Ischemia/reperfusion Injury via Upregulation of p70s6k1/p-p70s6k1

Frontiers in Pharmacology, 2017
Background and Aims: Tongxinluo (TXL) is a multifunctional traditional Chinese medicine that has been widely used to treat cardiovascular and cerebrovascular diseases.
Gui-hao Chen, Chuan-sheng Xu, Jie Zhang, Qing Li, He-he Cui, Xiang-dong Li, Li-ping Chang, Rui-jie Tang, Jun-yan Xu, Xia-qiu Tian, Pei-sen Huang, Jun Xu, Chen Jin, Yue-jin Yang   +13 more
doaj   +1 more source

Comparing the signaling and transcriptome profiling landscapes of human iPSC-derived and primary rat neonatal cardiomyocytes

Scientific Reports, 2023
The inaccessibility of human cardiomyocytes significantly hindered years of cardiovascular research efforts. To overcome these limitations, non-human cell sources were used as proxies to study heart function and associated diseases.
Kyla Bourque, Jace Jones-Tabah, Darlaine Pétrin, Ryan D. Martin, Jason C. Tanny, Terence E. Hébert   +5 more
doaj   +1 more source

Electrophysiological Biomarkers for Age-Related Changes in Human Atrial Cardiomyocytes: In Silico Study [PDF]

ITM Web of Conferences, 2020
Age-related changes in human cardiomyocytes are closely related to cardiac diseases, especially atrial fibrillation. Restricted availability of biological preparations from the human atrial myocardium complicates experimental studies on the aging ...
Nesterova Tatyana, Ushenin Konstantin, Shmarko Dmitry, Solovyova Olga   +3 more
doaj   +1 more source

S100A1 genetically targeted therapy reverses dysfunction of human failing cardiomyocytes [PDF]

, 2011
This study investigated the hypothesis whether S100A1 gene therapy can improve pathological key features in human failing ventricular cardiomyocytes (HFCMs)
Thierry Carrel, Henriette Brinks, Most, Patrick, Eckhart, Andrea D., Walter J. Koch, Sven T. Pleger, Qiu, Gang, Pleger, Sven T, Carrel, Thierry, Koch, Walter J, Mather, Paul J, David Rohde, Katus, Hugo A, Joseph Rabinowitz, Hugo A. Katus, Andrea D. Eckhart, Paul J. Mather, Mirko Voelkers, Arjang Ruhparwar, Rohde, David, Herzog, Nicole, Pleger, Sven T., Brinks, Henriette, Nicole Herzog, Carolin Lerchenmüller, Patrick Most, Rabinowitz, Joseph, Silvestry, Scott, Gang Qiu, Eckhart, Andrea D, Mather, Paul J., Lerchenmüller, Carolin, Katus, Hugo A., Koch, Walter J., Voelkers, Mirko, Ruhparwar, Arjang, Scott Silvestry   +36 more
core   +1 more source

Wang et al. Supplementary Files_DMD iPSC-cardiomyocytes

, 2023
The DMD iPSCs were differentiated into beating cardiomyocytes following the protocol for cardiac lineage differentiation based on a stepwise supplementation of iPSC medium with specific small molecules (Campostrini et al. 2021 Nat. Protoc., 16, 2213-2256.
Manuel Goncalves (17675433)
core   +1 more source

Slow Turning Lateral Vessel Bioreactor Improves Embryoid Body Formation and Cardiogenic Differentiation of Mouse Embryonic Stem Cells. [PDF]

, 2013
Embryonic stem cells (ESCs) have the ability to form aggregates, which are called embryoid bodies (EBs). EBs mimic early embryonic development and are commonly produced for cardiomyogenesis.
Tharasanit, T., Biology of Reproductive Cells, Pirity, M., Rungarunlert, Sasitorn, Klincumhom, Nuttha, Rungarunlert, S., Dinnyés, András, Tharasanit, Theerawat, Dep Gezondheidszorg Landbouwhuisdieren, Klincumhom, N., Techakumphu, M., Pirity, Melinda, Dinnyes, A.   +12 more
core   +2 more sources

The Effect of TWIK-1 Two Pore Potassium Channels on Cardiomyocytes in Low Extracellular Potassium Conditions

Frontiers in Bioscience-Landmark, 2023
Backgroound: At low extracellular potassium ([K+]e) conditions, human cardiomyocytes can depolarize to –40 mV. This is closely related to hypokalemia-induced fatal cardiac arrhythmia. The underlying mechanism, however, is still not well understood.
Ping Liu, Yawen Yang, Hengxi Zhang, Yingying Zhang, Jin Zeng, Dongchuan Zuo   +5 more
doaj   +1 more source

Characterization of cytoskeleton features and maturation status of cultured human iPSC-derived cardiomyocytes [PDF]

, 2017
Recent innovations in stem cell technologies and the availability of human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) have opened new possibilities for studies and drug testing on human cardiomyocytes in vitro.
Thomas M. Suter, Henriette Most, Priyanka Dutta-Passecker, Segiser, Adrian, Most, Henriette, Adrian Segiser, Suter, Thomas M, Zuppinger, Christian, Christian Zuppinger, Gibbons, George, George Gibbons, Dutta-Passecker, Priyanka   +11 more
core   +2 more sources