Results 21 to 30 of about 113,516 (292)

Comparing the signaling and transcriptome profiling landscapes of human iPSC-derived and primary rat neonatal cardiomyocytes

Scientific Reports, 2023
The inaccessibility of human cardiomyocytes significantly hindered years of cardiovascular research efforts. To overcome these limitations, non-human cell sources were used as proxies to study heart function and associated diseases.
Kyla Bourque, Jace Jones-Tabah, Darlaine Pétrin, Ryan D. Martin, Jason C. Tanny, Terence E. Hébert   +5 more
doaj   +2 more sources

Characterization of cytoskeleton features and maturation status of cultured human iPSC-derived cardiomyocytes

European Journal of Histochemistry, 2017
Recent innovations in stem cell technologies and the availability of human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) have opened new possibilities for studies and drug testing on human cardiomyocytes in vitro.
Christian Zuppinger, George Gibbons, Priyanka Dutta-Passecker, Adrian Segiser, Henriette Most, Thomas M. Suter   +5 more
doaj   +3 more sources

Base editing correction of hypertrophic cardiomyopathy in human cardiomyocytes and humanized mice. [PDF]

Nat Med, 2023
The most common form of genetic heart disease is hypertrophic cardiomyopathy (HCM), which is caused by variants in cardiac sarcomeric genes and leads to abnormal heart muscle thickening. Complications of HCM include heart failure, arrhythmia and sudden cardiac death.
Chai AC, Cui M, Chemello F, Li H, Chen K, Tan W, Atmanli A, McAnally JR, Zhang Y, Xu L, Liu N, Bassel-Duby R, Olson EN.   +12 more
europepmc   +4 more sources

Hypoxia and re-oxygenation effects on human cardiomyocytes cultured on polycaprolactone and polyurethane nanofibrous mats [PDF]

Journal of Biological Engineering
Heart diseases are caused mainly by chronic oxygen insufficiency (hypoxia), leading to damage and apoptosis of cardiomyocytes. Research into the regeneration of a damaged human heart is limited due to the lack of cellular models that mimic damaged ...
Zuzanna Iwoń, Ewelina Krogulec, Aleksandra Kierlańczyk, Michał Wojasiński, Elżbieta Jastrzębska   +4 more
doaj   +2 more sources

Cyclin A2 induces cytokinesis in human adult cardiomyocytes and drives reprogramming in mice

npj Regenerative Medicine
Cyclin A2 (CCNA2), a master cell cycle regulator silenced in postnatal cardiomyocytes, promotes cardiac repair in animal models. However, its effect on cytokinesis in adult human cardiomyocytes was previously unknown.
Esmaa Bouhamida, Sangeetha Vadakke-Madathil, Prabhu Mathiyalagan, Amaresh K. Ranjan, Amir Khan, Cherrie D. Sherman, Paul E. Miller, Andre Ghetti, Najah Abi-Gerges, Hina W. Chaudhry   +9 more
doaj   +2 more sources

Hydrogen sulfide suppresses outward rectifier potassium currents in human pluripotent stem cell-derived cardiomyocytes.

PLoS ONE, 2012
AimHydrogen sulfide (H₂S) is a promising cardioprotective agent and a potential modulator of cardiac ion currents. Yet its cardiac effects on humans are poorly understood due to lack of functional cardiomyocytes.
Heming Wei, Guangqin Zhang, Suhua Qiu, Jun Lu, Jingwei Sheng, Manasi, Grace Tan, Philip Wong, Shu Uin Gan, Winston Shim   +9 more
doaj   +2 more sources

Modeling Human Cardiac Hypertrophy in Stem Cell-Derived Cardiomyocytes

Stem Cell Reports, 2018
Summary: Cardiac hypertrophy accompanies many forms of cardiovascular diseases. The mechanisms behind the development and regulation of cardiac hypertrophy in the human setting are poorly understood, which can be partially attributed to the lack of a ...
Ekaterina Ovchinnikova, Martijn Hoes, Kirill Ustyantsev, Nils Bomer, Tristan V. de Jong, Henny van der Mei, Eugene Berezikov, Peter van der Meer   +7 more
doaj   +3 more sources

Potential Role of Lisinopril in Reducing Atherosclerotic Risk: Evidence of an Antioxidant Effect in Human Cardiomyocytes Cell Line

Frontiers in Pharmacology, 2022
The cellular mechanisms involved in myocardial ischemia/reperfusion injury (I/R) pathogenesis are complex but attributable to reactive oxygen species (ROS) production.
Lucia Scisciola, Rosaria Anna Fontanella, Surina, Giovanna Garofalo, Maria Rosaria Rizzo, Giuseppe Paolisso, Giuseppe Paolisso, Michelangela Barbieri   +7 more
doaj   +1 more source

MiRNA-615-3p Alleviates Oxidative Stress Injury of Human Cardiomyocytes Via PI3K/Akt Signaling by Targeting MEF2A

Anatolian Journal of Cardiology, 2022
Background: Myocardial infarction, a coronary heart disease, is a serious hazard to human health. Cardiomyocyte oxidative stress and apoptosis have been considered as the main causes of myocardial infarction. Here, we aimed to investigate the role of miR-
Dongying Zhang, Gang Zhang, Kun Yu, Xiwen Zhang, Aixia Jiang   +4 more
doaj   +1 more source

Cardiomyocyte Renewal in Humans [PDF]

Circulation Research, 2012
Pas de ...
Bergmann, Olaf, Zdunek, Sofia, Frisén, Jonas, Bernard, Samuel, Druid, Henrik, Jovinge, Stefan   +5 more
openaire   +4 more sources