Results 21 to 30 of about 103,809 (257)

Hypoxia Induces Cardiomyocyte Proliferation in Humans

JACC: Basic to Translational Science, 2020
The mammalian heart has a substantial regenerative capacity in the first few days of life mediated by cardiomyocyte proliferation; however, this capacity is lost shortly after birth ([1][1]). Transition from the embryonic to postnatal circulation results in a rapid and substantial increase in ...
Ahmed, Mahmoud S., Sadek, Hesham A.
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Live-Cell Imaging of the Contractile Velocity and Transient Intracellular Ca²⁺ Fluctuations in Human Stem Cell-Derived Cardiomyocytes

Cells, 2022
Live-cell imaging techniques are essential for acquiring vital physiological and pathophysiological knowledge to understand and treat heart disease. For live-cell imaging of transient alterations of [Ca2+]i in human cardiomyocytes, we engineered human ...
Aviseka Acharya, Harshal Nemade, Krishna Rajendra Prasad, Khadija Khan, Jürgen Hescheler, Nick Blackburn, Ruth Hemmersbach, Symeon Papadopoulos, Agapios Sachinidis   +8 more
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A modified method for isolation of human cardiomyocytes to model cardiac diseases

Journal of Translational Medicine, 2018
Background Cardiomyocytes derived from animals and induced pluripotent stem cells (iPSCs) are two main cellular models to study cardiovascular diseases, however, neither provides precise modeling of the response of mature human cardiomyocytes to disease ...
Guang-ran Guo, Liang Chen, Man Rao, Kai Chen, Jiang-ping Song, Sheng-shou Hu   +5 more
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Yulink, predicted from evolutionary analysis, is involved in cardiac function

Journal of Biomedical Science, 2021
Background The comparative evolutionary genomics analysis was used to study the functions of novel Ka/Ks-predicted human exons in a zebrafish model. The Yulink (MIOS, Entrez Gene: 54,468), a conserved gene from zebrafish to human with WD40 repeats at N ...
Ming-Wei Kuo, Hsiu-Hui Tsai, Sheng-Hung Wang, Yi-Yin Chen, Alice L. Yu, John Yu   +5 more
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In Vivo Maturation of Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes in Neonatal and Adult Rat Hearts

Stem Cell Reports, 2017
We hypothesized that the neonatal rat heart would bring transplanted human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) to maturity as it grows to adult size.
Shin Kadota, Lil Pabon, Hans Reinecke, Charles E. Murry   +3 more
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Comparing the signaling and transcriptome profiling landscapes of human iPSC-derived and primary rat neonatal cardiomyocytes

Scientific Reports, 2023
The inaccessibility of human cardiomyocytes significantly hindered years of cardiovascular research efforts. To overcome these limitations, non-human cell sources were used as proxies to study heart function and associated diseases.
Kyla Bourque, Jace Jones-Tabah, Darlaine Pétrin, Ryan D. Martin, Jason C. Tanny, Terence E. Hébert   +5 more
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Effects of local activation times on the tension development of human cardiomyocytes in a computational model

Current Directions in Biomedical Engineering, 2018
The human heart is an organ of high complexity and hence, very challenging to simulate. To calculate the force developed by the human heart and therefore the tension of the muscle fibers, accurate models are necessary.
Müller Armin, Kovacheva Ekaterina, Schuler Steffen, Dössel Olaf, Baron Lukas   +4 more
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Burst-Like Transcription of Mutant and Wildtype MYH7-Alleles as Possible Origin of Cell-to-Cell Contractile Imbalance in Hypertrophic Cardiomyopathy

Frontiers in Physiology, 2018
Hypertrophic Cardiomyopathy (HCM) has been related to many different mutations in more than 20 different, mostly sarcomeric proteins. While development of the HCM-phenotype is thought to be triggered by the different mutations, a common mechanism remains
Judith Montag, Kathrin Kowalski, Mirza Makul, Pia Ernstberger, Ante Radocaj, Julia Beck, Edgar Becker, Snigdha Tripathi, Britta Keyser, Christian Mühlfeld, Kirsten Wissel, Andreas Pich, Jolanda van der Velden, Cristobal G. dos Remedios, Andreas Perrot, Antonio Francino, Francesco Navarro-López, Bernhard Brenner, Theresia Kraft   +18 more
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Electrophysiological Biomarkers for Age-Related Changes in Human Atrial Cardiomyocytes: In Silico Study [PDF]

ITM Web of Conferences, 2020
Age-related changes in human cardiomyocytes are closely related to cardiac diseases, especially atrial fibrillation. Restricted availability of biological preparations from the human atrial myocardium complicates experimental studies on the aging ...
Nesterova Tatyana, Ushenin Konstantin, Shmarko Dmitry, Solovyova Olga   +3 more
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Assessment of Cardiomyocyte Contraction in Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes [PDF]

Toxicological Sciences, 2014
Functional changes to cardiomyocytes are a common cause of attrition in preclinical and clinical drug development. Current approaches to assess cardiomyocyte contractility in vitro are limited to low-throughput methods not amenable to early drug discovery.
Amy, Pointon, Alexander R, Harmer, Ian L, Dale, Najah, Abi-Gerges, Joanne, Bowes, Christopher, Pollard, Helen, Garside   +6 more
openaire   +2 more sources