Results 21 to 30 of about 9,526,153 (337)

Selenoprotein DIO2 Is a Regulator of Mitochondrial Function, Morphology and UPRmt in Human Cardiomyocytes

International Journal of Molecular Sciences, 2021
Members of the fetal-gene-program may act as regulatory components to impede deleterious events occurring with cardiac remodeling, and constitute potential novel therapeutic heart failure (HF) targets.
N. Bomer, Mario G. Pavez-Giani, F. Deiman, Annet N. Linders, M. Hoes, Christiane L.J. Baierl, S. Oberdorf‐Maass, Rudolf A. de Boer, Herman H. W. Silljé, Eugene Berezikov, W. Simonides, B. Westenbrink, P. van der Meer   +12 more
semanticscholar   +1 more source

Identification of miRNAs as Biomarkers of Cardiac Protection in Non-Genetically Modified Primary Human Cardiomyocytes Exposed to Halogenated Hypnotics in an In Vitro Model of Transfection and Ischemia/Reperfusion: A New Model in Translational Anesthesia

Life, 2022
Background: Many clinical studies have identified some circulating micro-RNAs (miRNAs) as potential biomarkers with regard to the cardioprotective effects of halogenated agents administered perioperatively during myocardial conditioning procedures ...
Maria Dolores Carmona-Luque, Laura Gonzalez-Alvarez, José Luis Guerrero Orriach   +2 more
doaj   +1 more source

Comparative Effect of MSC Secretome to MSC Co-culture on Cardiomyocyte Gene Expression Under Hypoxic Conditions in vitro

Frontiers in Bioengineering and Biotechnology, 2020
IntroductionDespite major leaps in regenerative medicine, the regeneration of cardiomyocytes after ischemic conditions remains to elucidate. It is crucial to understand hypoxia induced cellular mechanisms to provide advanced treatment options, including ...
Nina Kastner, Julia Mester-Tonczar, Johannes Winkler, Denise Traxler, Andreas Spannbauer, Beate M. Rüger, Georg Goliasch, Noemi Pavo, Mariann Gyöngyösi, Katrin Zlabinger   +9 more
doaj   +1 more source

Empagliflozin and Dapagliflozin Increase Na⁺ and Inward Rectifier K⁺ Current Densities in Human Cardiomyocytes Derived from Induced Pluripotent Stem Cells (hiPSC-CMs)

Cells, 2022
Dapagliflozin (dapa) and empagliflozin (empa) are sodium-glucose cotransporter-2 inhibitors (SGLT2is) that reduce morbidity and mortality in heart failure (HF) patients.
María Dago, Teresa Crespo-García, Anabel Cámara-Checa, Josu Rapún, Marcos Rubio-Alarcón, María Marín, Juan Tamargo, Ricardo Caballero, Eva Delpón   +8 more
doaj   +1 more source

Preconditioning human cardiomyocytes and endothelial cells [PDF]

The Journal of Thoracic and Cardiovascular Surgery, 1998
The effects of simulated "ischemia" and "reperfusion" were evaluated in cell cultures of human ventricular cardiomyocytes and human saphenous vein endothelial cells.Myocyte and endothelial cell cultures were exposed to a low volume (1.5 ml) of either hypoxic (oxygen tension = 16 mm Hg) or anoxic (oxygen tension = 0 mm Hg) phosphate-buffered saline ...
Shirai, Toshizumi, Rao, Vivek, Weisel, Richard D., Ikonomidis, John S., Li, Ren-Ke, Tumiati, Laura C., Merante, Frank, Mickle, Donald A.   +7 more
openaire   +2 more sources

The implementation of persuasive technology principles in mobile application development: a qualitative study [PDF]

, 2012
Preceding studies of persuasive technology have mentioned several benefits on the implementation of persuasive design features of the Persuasive System Design (PSD) model such as creating users' engagement and acceptance and continuous usage.
Abd Rahim, Mohd Hilmi Izwan, Goh, Kai Chen, Masrom, Md Asrul Nasid, Mohamed, Sulzakimin, Yunus, Riduan   +4 more
core   +3 more sources

SARS-CoV-2 infects and induces cytotoxic effects in human cardiomyocytes

bioRxiv, 2020
Background The coronavirus disease 2019 (COVID-19) is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and has emerged as global pandemic.
D. Bojkova, J. Wagner, M. Shumliakivska, G. S. Aslan, Umber Saleem, A. Hansen, G. Luxán, S. Günther, M. Pham, J. Krishnan, P. Harter, U. Ermel, A. Frangakis, A. Zeiher, H. Milting, J. Cinatl, A. Dendorfer, T. Eschenhagen, S. Ciesek, S. Dimmeler   +19 more
semanticscholar   +1 more source

Cardiomyocytes Derived from Human CardiopoieticAmniotic Fluids [PDF]

Scientific Reports, 2018
AbstractHuman amniotic fluid (hAF) cells share characteristics of both embryonic and adult stem cells. They proliferate rapidly and can differentiate into cells of all embryonic germ layers but do not form teratomas. Embryoid-bodies obtained from hAF have cardiac differentiation potential, but terminal differentiation to cardiomyocytes (CMs) has not ...
Di Baldassarre, Angela, D’Amico, Maria A., Izzicupo, Pascal, Gaggi, Giulia, Guarnieri, Simone, Mariggiò, Maria A., Antonucci, Ivana, Corneo, Barbara, Sirabella, Dario, Stuppia, Liborio, Ghinassi, Barbara   +10 more
openaire   +2 more sources

Single-cell transcriptomic profiling reveals specific maturation signatures in human cardiomyocytes derived from LMNB2-inactivated induced pluripotent stem cells

Frontiers in Cell and Developmental Biology, 2022
Mammalian cardiomyocyte maturation entails phenotypic and functional optimization during the late fetal and postnatal phases of heart development, both processes driven and coordinated by complex gene regulatory networks.
Jie Wang, William Morgan, William Morgan, William Morgan, Ankur Saini, Ankur Saini, Ankur Saini, Tao Liu, John Lough, John Lough, Lu Han, Lu Han, Lu Han   +12 more
doaj   +1 more source

Hypoxia Induces Cardiomyocyte Proliferation in Humans

JACC: Basic to Translational Science, 2020
The mammalian heart has a substantial regenerative capacity in the first few days of life mediated by cardiomyocyte proliferation; however, this capacity is lost shortly after birth ([1][1]). Transition from the embryonic to postnatal circulation results in a rapid and substantial increase in ...
Ahmed, Mahmoud S., Sadek, Hesham A.
openaire   +2 more sources