Results 111 to 120 of about 5,413,831 (314)
Contending with animal bones (Editorial) [PDF]
, 1999 [FIRST PARAGRAPH] This issue has been assembled in order to focus on some of the current directions in animal remains research. Since serious study of ancient animal remains began in the nineteenth century, this field and its specific areas of inquiry ...
Fuller, D., Milner, N.
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Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
The diversity of livestock systems and definition of animal welfare (2nd NAHWOA Workshop) [PDF]
, 2000 content: Part A: Livestock in organic farming: role and research methodologies Part B: The diversity of organic livestock systems – Austria and Spain Part C: Organic livestock production standards Part D: Organic livestock production and animal ...
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Animals in cardiovascular research [PDF]
European Heart Journal, 2020 Cesarovic, N +3 more
openaire +4 more sources
Molecular Oncology, EarlyView.Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon +9 more
wiley +1 more source
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
The role and management of herbal pastures for animal health, productivity and product quality [PDF]
, 2008 This review seeks to address the role and management of herbal pastures for animal health, productivity and product quality. It aims to do this by way of reviewing available Defra funded and other research and identifying key and relevant aspects.
Burke, Geoffrey
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Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
The Scientific Case for Animal Models: A Perspective From Musculoskeletal Researchers
FASEB BioAdvancesThe National Institutes of Health (NIH) has launched a major initiative to expand human‐based New Approach Methodologies (NAMs) in biomedical research and reduce reliance on animal models.
Michael Hadjiargyrou +4 more
doaj +1 more source