Results 101 to 110 of about 5,413,831 (314)
Effects of Euthanasia on Animal Research
Veterinary Biomedical and Clinical JournalThe use of experimental animals is widely conducted in the medical field, both for research on the processes of disease occurrence (pathogenesis), the causes of disease (etiology), and research on therapy.
Ni Putu Radela Maharani +3 more
doaj +1 more source
Human - animal relationship: stockmanship and housing in organic livestock systems (3rd NAHWOA Workshop) [PDF]
, 2001 content: Part A: Human-animal relationship: stockmanship and housing Part B: Reports on on-going research and new research concepts Part C: Posters Part D: Farm visit The theme of the 3 rd NAHWOA Workshop was Human-animal relationship ...
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Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
Networks learn from learning histories [PDF]
, 2011 The research programme Networks in Animal Husbandry began in 2004 without any concrete final objectives. The programme did have to contribute in all sorts of ways: by making “knowledge from the shelf” applicable, to making animal farming more robust ...
Zaalmink, W.
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Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Role of Exercise in Pulmonary Hypertension: Evidence from Bench to Bedside
PulseBackground: Pulmonary hypertension (PH) is a debilitating condition characterized by elevated pulmonary arterial pressure and progressive vascular remodelling, leading to exercise intolerance.
Ganesha Poojary +3 more
doaj +1 more source
Integrating socio-eco-epidemiological approaches into health research [PDF]
, 2012 Sixty percent of emerging infectious diseases events are zoonotic and among those, 72% are caused by pathogens of wildlife origin. The distribution and intensity of most animal and zoonotic diseases have changed in recent years in response to ...
Gaidet, Nicolas, Molia, Sophie
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Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
Frontiers in PharmacologyType 2 diabetes (T2D) is a complex metabolic disorder characterized by alterations in multiple pathways of carbohydrate and lipid metabolism. Due to the involvement of a network of dysfunctional enzymes contributing to hyperglycemia, ethnopharmacological
Fernanda Artemisa Espinoza-Hernández +6 more
doaj +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source