Results 81 to 90 of about 5,413,831 (314)

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Low-cost, open-source device for simultaneously subjecting rodents to different circadian cycles of light, food, and temperature

Frontiers in Physiology
Exposure of experimental rodents to controlled cycles of light, food, and temperature is important when investigating alterations in circadian cycles that profoundly influence health and disease. However, applying such stimuli simultaneously is difficult
Ramon Farré, Ramon Farré, Ramon Farré, Miguel A. Rodríguez-Lázaro, Jorge Otero, Jorge Otero, Jorge Otero, Núria Gavara, Núria Gavara, Raimon Sunyer, Raimon Sunyer, Núria Farré, Núria Farré, David Gozal, Isaac Almendros, Isaac Almendros, Isaac Almendros   +16 more
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

The 3Rs of Animal Research [PDF]

eBioMedicine, 2022
openaire   +2 more sources

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

The process of minimising medicine use through dialogue based animal health and welfare planning, Workshop report FIBL. In: CORE Organic project no. 1903 - ANIPLAN [PDF]

, 2011
The process of minimising medicine use through dialogue based animal health and welfare planning. Livestock are important in many organic farming systems, and it is an explicit goal to ensure high levels of animal health and welfare (AHW) through good
Alfoeldi, Thomas, Algers, Bo, Brinkmann, Jan, Gantner, Urs, Gratzer, Elisabeth, Hansen, Berit, Hassing, M., Henriksen, Britt I. F., Huber, Johann, Ivemeyer, Silvia, Leeb, Christine, March, Solveig, Mejdell, Cecilie, Nicholas, Phillipa, Roderick, Stephen, Smolders, Gidi, Stöger, Elisabeth, Vaarst, Mette, Walkenhorst, Michael, Whay, Becky, Whistance, Lindsay, Winckler, Christoph   +21 more
core  

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

Swedish research in organic farming and food systems [PDF]

, 2006
In Sweden research is mainly conducted by researchers at the Swedish University of Agricultural Sciences (SLU). The SLU departments of Soil Science, Ecology and Crop Production Science (now Crop Production Ecology), Entomology, Animal Nutrition and ...
Alm, Jessica, Geber, Ulrika, Nilsdotter-Linde, Nilla   +2 more
core