Results 81 to 90 of about 53,985,043 (260)

Animal Ethical Views and Perception of Animal Pain in Veterinary Students [PDF]

, 2018
Veterinary students face several ethical challenges during their curriculum. We used the Animal Ethics Dilemma to study animal ethical views of Finnish veterinary students, and also asked them to score the level of pain perception in 13 different species.
Valros, Anna Elisabet, Laura Hänninen, Hänninen, Laura Talvikki, Anna Valros   +3 more
core   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Decoding the dynamic extracellular matrix in cancer—3D models and bioscaffolds rewire the rules of tumor progression

FEBS Letters, EarlyView.
Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani, Konstantinos Spanopoulos, Zoi Piperigkou, Nikos K. Karamanos   +3 more
wiley   +1 more source

Moral shocks to invoke compassion: depicting the suffering and death of animals in animal research and testing facilities

Journal of Aesthetics & Culture
This article presents a preposterous history of moral shocks regarding animals in research and testing facilities. Moral shock is a concept developed by James M. Jasper. It reveals how protest images of suffering animals, as a consequence of research and
Victor J. Krawczyk
doaj   +1 more source

A Kenyan perspective on the use of animals in science education and scientific research in Africa and prospects for improvement

The Pan African Medical Journal, 2011
BACKGROUND: Animal experimentation is common in Africa, a region that accords little priority on animal protection in comparison to economic and social development.
Charles Kimwele, Duncan Matheka, Hope Ferdowsian   +2 more
doaj   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Understanding animal social structure: exponential random graph models in animal behaviour research [PDF]

, 2017
This is the author accepted manuscript. The final version is available from Elsevier Masson via the DOI in this record.The social environment is a pervasive influence on the ecological and evolutionary dynamics of animal populations.
Matthew J. Silk, Silk, Matthew J, Fisher, D.N., Silk, MJ, David N. Fisher, Fisher, DN   +5 more
core   +1 more source

Histopathological Evaluation of Bioactive Glass Wound Sites in a Swine Model

Bioengineering
Chronic wounds, including diabetic foot ulcers (DFUs), venous leg ulcers (VLUs), and pressure injuries, remain a major global health burden and contribute substantially to Medicare spending. Because traditional wound dressings fail to address the dynamic
Daniel A. Rabin, Aneeq S. Chaudhry, Tarifa H. Adam, Katherine Kozlowski, Marlynn P. Lopez, Tiffany Kim, Spencer Green, Robert D. Galiano, Gregory C. Manista, Donald W. Buck, Steven Jung   +10 more
doaj   +1 more source