Results 191 to 200 of about 53,985,043 (260)

"Killing in the Name of 3R?" The Ethics of Death in Animal Research. [PDF]

J Agric Environ Ethics
Persson K, Rodriguez Perez C, Louis-Maerten E, Müller N, Shaw D.   +4 more
europepmc   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Advocating for automation in animal research: using home cage monitoring to advance welfare, reproducibility and scientific openness. [PDF]

Dis Model Mech
COST Action TEATIME CA20135 welfare group.
europepmc   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Replicability and Reproducibility in Comparative Psychology

Frontiers in Psychology, 2017
Jeffrey R. Stevens
doaj   +1 more source

Right Ventricular Pressure-Volume Loop Analysis in Large Animal Research: A Scoping Review of Current Practices Using Conductance and Admittance Catheters. [PDF]

Pulm Circ
Orlitová M, Hellinck J, Dam Lyhne M, Granfeldt A, Neyrinck AP, Verbelen T, Claus P.   +6 more
europepmc   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

Institutional animal care and use committees and the challenges of evaluating animal research proposals. [PDF]

Res Integr Peer Rev
Pippin JJ, Bailey J, Kennedy M, Press DD, McCarthy J, Baron R, Farghali S, Baker E, Barnard ND.   +8 more
europepmc   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Ethanol-Induced Dysbiosis and Systemic Impact: A Meta-Analytical Synthesis of Human and Animal Research. [PDF]

Microorganisms
Alexandrescu L, Tofolean IT, Tofolean DE, Nicoara AD, Twakor AN, Rusu E, Preotesoiu I, Dumitru E, Dumitru A, Tocia C, Herlo A, Alexandrescu DM, Popescu I, Cimpineanu B.   +13 more
europepmc   +1 more source