Results 181 to 190 of about 5,413,831 (314)

Clearance of antibody-VSG complexes by trypanosomes [PDF]

, 2012
International Laboratory for Research on Animal Diseases
core  

Creative pedagogic methods for self-guided embodied thinking and learning about animal research. [PDF]

Wellcome Open Res
Roe E, Bailey SJ, Mackenzie L, Tremoleda JL.   +3 more
europepmc   +1 more source

Insights into a long life without cancer: The case of the bowhead whale

Molecular Oncology, EarlyView.
Long‐lived, large‐bodied organisms have evolved powerful anticancer mechanisms that preserve cellular and tissue integrity across extended lifespans. A recent study by Firsanov et al. shows that greater genome stability is a key factor underlying the remarkable longevity and cancer resistance of one such species, the bowhead whale.
Inés Paniagua, Johanna A. Joyce
wiley   +1 more source

Trypanosome infection causes dysfunction of the pituitary gland [PDF]

, 2012
International Laboratory for Research on Animal Diseases
core  

Ethanol-Induced Dysbiosis and Systemic Impact: A Meta-Analytical Synthesis of Human and Animal Research. [PDF]

Microorganisms
Alexandrescu L, Tofolean IT, Tofolean DE, Nicoara AD, Twakor AN, Rusu E, Preotesoiu I, Dumitru E, Dumitru A, Tocia C, Herlo A, Alexandrescu DM, Popescu I, Cimpineanu B.   +13 more
europepmc   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

ILRAD 1985. Annual report of the International Laboratory for Research on Animal Diseases [PDF]

, 2014
International Laboratory for Research on Animal Diseases
core   +1 more source

Institutional animal care and use committees and the challenges of evaluating animal research proposals. [PDF]

Res Integr Peer Rev
Pippin JJ, Bailey J, Kennedy M, Press DD, McCarthy J, Baron R, Farghali S, Baker E, Barnard ND.   +8 more
europepmc   +1 more source

Molecular cancer prevention: Intercepting disease

Molecular Oncology, EarlyView.
Oncological practice must evolve, from treating established tumours to proactive cancer interception before clinical manifestation. This will require mechanistic insight into tumour initiation, validated biomarkers of early disease development and redesigned clinical trials, enabling cancer interception to become a core pillar of oncology with the ...
Charlotte Grieco, Tej Pandya, Charles Swanton   +2 more
wiley   +1 more source

Two genes encode an important trypanosome protein [PDF]

, 2012
International Laboratory for Research on Animal Diseases
core