Results 161 to 170 of about 5,413,831 (314)

Dual roles of complement in ulcerative colitis: insights from clinical studies and animal research. [PDF]

Eur J Med Res
Qin Z, Wang R, Zhang Y.
europepmc   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

A Trypanosoma congolense-specific antigen released in the course of an infection is identified as a thiol protease precursor [PDF]

, 2012
International Laboratory for Research on Animal Diseases
core  

Identification and Characterization of MmuPV1 Causing Papillomatosis Outbreak in an Animal Research Facility. [PDF]

Viruses
Majerciak V, Killoran KE, Yu L, Gotte D, Edmondson E, Breed MW, King RE, Roelke-Parker ME, Lambert PF, Kramer JA, Zheng ZM.   +10 more
europepmc   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Role of macrophages in development of anaemia in trypanosomiasis [PDF]

, 2012
International Laboratory for Research on Animal Diseases
core  

"Lost in translation?" Animal research in the era of precision medicine. [PDF]

J Transl Med
Frühwein H, Paul NW.
europepmc   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Tick-borne diseases of livestock [PDF]

, 2012
International Laboratory for Research on Animal Diseases
core  

Knowledge, Attitudes, and Practices on Ethics in Biomedical Animal Research in Mexico. [PDF]

J Am Assoc Lab Anim Sci, 2023
Heredia-Antúnez A, Galarde-López M, Téllez-Ballesteros E, Vanda-Cantón B.   +3 more
europepmc   +1 more source