Results 151 to 160 of about 5,413,831 (314)

Drug tapering in animal research: current practices and challenges. [PDF]

Front Pharmacol
Zhang Y, Chen M, Jiang T, Fu Q, Ma R, Nie L, You Y, Gao S, Rong P.   +8 more
europepmc   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

ILRAD's links with global animal disease research [PDF]

, 2012
International Laboratory for Research on Animal Diseases
core  

Developing more inclusive approaches to animal research and patient involvement. [PDF]

Med Health Care Philos
Azilagbetor DM, Davies G, Geneviève LD, Shaw DM, Elger BS.   +4 more
europepmc   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Towards an improved East Coast fever vaccine: evening the odds [PDF]

, 2012
International Laboratory for Research on Animal Diseases
core  

Presentation and characterisation of the ALBA micro8 system for targeted hyperthermia in small animal research. [PDF]

Sci Rep
Groen JA, Zweije R, Sijbrands J, Scutigliani EM, van Laarhoven HWM, Bijlsma MF, Crezee J, Kok HP.   +7 more
europepmc   +1 more source

Implementing the 3Rs in Laboratory Animal Research-From Theory to Practice. [PDF]

Animals (Basel), 2023
Azkona G.
europepmc   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

ILRAD research updates [PDF]

, 2012
International Laboratory for Research on Animal Diseases
core