Results 141 to 150 of about 5,413,831 (314)

The role cytotoxic T cells play in protecting livestock against Theileria parva [PDF]

, 2012
International Laboratory for Research on Animal Diseases
core  

New Insights into Neuromuscular Junction Biology: Evidence from Human and Animal Research. [PDF]

Int J Mol Sci
Liang Z, Chen X, Nourbakhsh M.
europepmc   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Do T cells help animals develop immunity to trypanosomiasis [PDF]

, 2012
International Laboratory for Research on Animal Diseases
core  

FELASA recommendations for continuing professional development for professionals involved in animal research. [PDF]

Lab Anim
Castelhano-Carlos MJ, Gyger M, Van Ginneken C, Sjöquist M, Bugnon P, Santos AI.   +5 more
europepmc   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Geographic Information Systems [PDF]

, 2012
International Laboratory for Research on Animal Diseases
core  

Building resilience in animal research: a two-year mixed methods survey of organizational support programs. [PDF]

Front Vet Sci
Young L, Thompson-Iritani S, Bellanca RU, Ferrara F, Bell K, Martin T, LaFollette MR.   +6 more
europepmc   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Experiments with twin calves offer evidence that cytotoxic T cells can clear T. parva infections [PDF]

, 2012
International Laboratory for Research on Animal Diseases
core