Results 251 to 260 of about 5,413,831 (314)

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

Exon 7 splicing of ERα predicts poor prognosis and increases phenotypic heterogeneity in luminal a subtype breast cancer

FEBS Open Bio, EarlyView.
ERα splice variant ERα∆7 lacks the C‐terminus, and its expression may change phenotypes of breast cancers. Our results showed that ERα∆7 is found in the luminal A subtype, and elevated ERα∆7 levels are linked to improved cell survival with lower proliferation and migration.
Long Wai Tsui, Taobo Hu, Thomson Christian Husein, Wai Hei Shek, Bingrong Chen, Depeng Wang, Shu Wang, Weichuan Yu, Xiaodan Fan, Mengping Long, Toyotaka Ishibashi   +10 more
wiley   +1 more source

The organ-on-a-chip mirage: Animal replacement, plastic channels, and plastic claims: <i>The False Narrative Behind the War on Animal Research</i>. [PDF]

Innov Emerg Technol
Yarmush ML.
europepmc   +1 more source

Biosafety Risk Control Strategies in Laboratory Animal Research. [PDF]

Saf Health Work
Weng ST, Li QW, Gao YD, Qiu YF.
europepmc   +1 more source

Reporting quality of animal research in journals that published the ARRIVE 1.0 or ARRIVE 2.0 guidelines: a cross-sectional analysis of 943 studies. [PDF]

Cardiovasc Diagn Ther
Lin Y, Yang F, Shang B, Speich JE, Wan YY, Hashida H, Braun T, Sadoughi A, Puehler T, Lue TF, Zhang K.   +10 more
europepmc   +1 more source

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Animal research through a lens: transparency on animal research

Journal of Medical Ethics, 2015
Transparency involves communicating meaningful information (eg, data or details of decision-making processes) to audiences, openly and honestly, with the intention of informing , enabling understanding and meeting responsibilities of accountability . The paper in this issue by Levin and Reppy1 highlights the value of transparency in improving ethical ...
J W, Yeates, B, Reed
openaire   +2 more sources