Results 121 to 130 of about 1,006,645 (347)
In Testing Times: Conducting an Ethnographic Study of UK Animal Rights Protesters [PDF]
This article reflects upon the experience of conducting research into a UK-based, though internationally-renowned, animal rights group. The article firstly rationalizes the ethnographic research methodology used to approach Stop Huntingdon Animal Cruelty
Andrew Upton
core
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
Freedom: Animal rights, human rights, and superhuman rights [PDF]
Fowler, Corbin, Manig, Thomas
core +2 more sources
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Raízes da resistência humana aos direitos dos animais: Bloqueios psicológicos e conceituais [PDF]
A combined psychological-epistemological study of the human blocks that stand in the way of the recognition of non-human animal sentience and legal rights.
Bartlett, Steven James
core +1 more source

