Results 141 to 150 of about 5,350,274 (343)
Molecular Oncology, EarlyView.We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu +10 more
wiley +1 more source
The street is no place for dogs: swinging wildly between wanton killing of dogs and extreme ‘pro-life’ interventions, India has never framed a rational, scientifically valid dog ownership or population control strategy [PDF]
, 2016 Everyday, India wakes up to horrific stories of attacks on people by street dogs and equally horrific acts of cruelty towards dogs. There is extreme polarisation on this issue between the advocates of human rights versus animal rights.
Belsare, Aniruddha, Vanak, Abi Tamim
core
Molecular Oncology, EarlyView.CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak +10 more
wiley +1 more source
Affect and Ethics in Mike Malloy’s Insure the Life of an Ant
ArtsThis essay examines a little-known but important installation entitled Insure the Life of an Ant, conceived by artist Mike Malloy and displayed at the O.K. Harris Gallery in New York in April of 1972.
Gerald Silk
doaj +1 more source
The Distributional Implications for Higher Farm Animal Welfare in New Zealand [PDF]
Over the past few decades the relative price of eggs has fallen dramatically in New Zealand. This has been made possible, at least in part, by the application of increasingly intensive agricultural practices.
Bicknell, Kathryn
core +1 more source
Progress Toward Replacing Animals in Toxicity Testing for Cosmetics [PDF]
, 2012 In the 1980’s, animal rights activists successfully motivated the cosmetic industry to begin researching alternatives to animal tests.
Nye, Marisa B.
core
Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source
Molecular Oncology, EarlyView.Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata +10 more
wiley +1 more source
Animal Rights -‘One-of-Us-ness’: From the Greek Philosophy towards a Modern Stance [PDF]
, 2018 Animals, the beautiful creatures of God in the Stoic and especially in Porphyry’s sense, need to be treated as rational. We know that the Stoics ask for justice to all rational beings, but I think there is no significant proclamation from their
Chakraborty, Sanjit
core