Results 91 to 100 of about 29,937,807 (297)

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Editorial: Buffalo Health and Production

Frontiers in Veterinary Science, 2022
Antonio Humberto Hamad Minervino, Domenico Vecchio, André Mendes Jorge, Selwyn Arlington Headley   +3 more
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Citizen science as a new tool in dog cognition research [PDF]

, 2015
The work of Á.M. was supported by the Hungarian Academy of Sciences (MTA 01 031).Family dogs and dog owners offer a potentially powerful way to conduct citizen science to answer questions about animal behavior that are difficult to answer with more ...
Josep Call, Vanessa Woods (796561), Sayan Mukherjee, Laughlin Stewart (796559), Woods, Vanessa, Rodriguez, Kerri, Cohen, E., Juliane Kaminski (128853), Ivy, David, Sayan Mukherjee (43870), Hare, B., McIntyre, Matthew, Miklósi, Á, Brian Hare (31689), Woods, V., Kaminski, Juliane, Brian Hare, Hare, Brian, Mukherjee, Sayan, Cohen, Eliot, Woods, V, Call, Josep, Kaminski, J., Vanessa Woods, Eliot Cohen, Wrangham, Richard, Maclean, Evan L., McIntyre, M, Stewart, L., Laughlin Stewart, Matthew McIntyre (796564), Call, J. ; https://orcid.org/, MacLean, EL, Evan L MacLean, Wrangham, RW, Josep Call (109947), Richard W. Wrangham (273125), Eliot Cohen (796562), Ádám Miklósi, David Ivy (796560), Ivy, D, Cohen, E, Kaminski, J, Rodriguez, K, Mukherjee, S, McIntyre, M., MacLean, E., David Ivy, Wrangham, Richard W., Kerri Rodriguez (796563), Richard W Wrangham, Kerri Rodriguez, Stewart, Laughlin, Juliane Kaminski, Rodriguez, K., Ivy, D., Miklósi, Á., Wrangham, R., Evan L. MacLean (427280), Call, J, Ádám Miklósi (235256), Stewart, L, Hare, B, Mukherjee, S., Miklósi, Ádám, Matthew McIntyre   +65 more
core   +1 more source

Decoding the dynamic extracellular matrix in cancer—3D models and bioscaffolds rewire the rules of tumor progression

FEBS Letters, EarlyView.
Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani, Konstantinos Spanopoulos, Zoi Piperigkou, Nikos K. Karamanos   +3 more
wiley   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Animal Science Complex laboratory at South Dakota State University, 1977

, 1977
Laboratory in the new Animal Science Complex on the campus of South Dakota State ...

core   +1 more source

ПРОТОФОРМА НА СЪВРЕМЕННАТА КОНСУЛТАНТСКА СЛУЖБА В НАПРАВЛЕНИЕ ЖИВОТНОВЪДСТВО И ВЕТЕРИНАРНА МЕДИЦИНА ІІ. НАЦИОНАЛЕН ЦЕНТЪР ЗА ВНЕДРЯВАНЕ В ЖИВОТНОВЪДСТВОТО И ЗЕМЕДЕЛИЕТО

Животновъдни науки, 2012
The present study analyzed the effectiveness of using the achievements of animal science in Bulgaria by the created National Center for Introduction in agriculture as well as informative and historical display his role as protoform of modern extension ...
ЧОНКА МИТЕВА, СТАЙКА ЛАЛЕВА, ПЕТЯ СЛАВОВА, ВАЛЕНТИН КАЦАРОВ, МИТКО ЛАЛЕВ, ТОДОРКА АТАНАСОВА, РУМЕН ОТУЗБИРОВ   +6 more
doaj