Results 101 to 110 of about 3,617,201 (358)

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

open access: yesMolecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker   +16 more
wiley   +1 more source

Sistemas forrageiros no semiárido do Estado do Ceará: tipologia estrutural = Forage systems in the semiarid of Ceará State: structural typology

open access: yesActa Scientiarum: Animal Sciences, 2010
Objetivou-se estabelecer a tipologia estrutural dos sistemas forrageiros (SIFs) em 57 unidades de produção rural cearenses localizadas no semiárido. Dezoito variáveis sobre utilização de superfícies, unidades e cargas animais, instalações e mão-de-obra ...
Déa de Lima Vidal
doaj  

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

open access: yesMolecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad   +17 more
wiley   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

open access: yesMolecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero   +11 more
wiley   +1 more source

Editorial: First Issue

open access: yesAnimal, 2007
‘ANIMAL – An International Journal of Animal Bioscience’ is the central element in a new and exciting collaborative venture between the European Federation for Animal Science (EAAP), Institut National de la Recherche Agronomique (INRA), and British ...
doaj   +1 more source

Solving new world animal science problems with a multidisciplinary approach

open access: diamond, 2021
S. Hatcher   +5 more
openalex   +1 more source

Plasma extrachromosomal circular DNA as a biomarker in EGFR‐targeted therapy of non‐small cell lung cancer

open access: yesMolecular Oncology, EarlyView.
Detection of extrachromosomal circular DNA (eccDNA) in plasma samples from EGFR‐mutated non‐small cell lung cancer patients. Plasma was collected before and during treatment with the EGFR‐tyrosine kinase inhibitor osimertinib. Plasma eccDNA was detected in all cancer samples, and the presence of the EGFR gene on eccDNA serves as a potential biomarker ...
Simone Stensgaard   +5 more
wiley   +1 more source

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