Results 141 to 150 of about 1,812,118 (303)

Analysis of RASFF notifications for mycotoxins in 2020–2022

Ветеринария сегодня
Introduction. Mycotoxins are secondary metabolites of various fungi. The contamination with mycotoxins is subject to control. Pursuant to the accepted classification in accordance with Council Directive 96/23/EC they belong to group B3: “Other substances
S. S. Ibragimova, O. V. Pruntova, N. B. Shadrova, T. V. Zhbanova   +3 more
doaj   +1 more source

STopTox: An in Silico Alternative to Animal Testing for Acute Systemic and Topical Toxicity. [PDF]

Environ Health Perspect, 2022
Borba JVB, Alves VM, Braga RC, Korn DR, Overdahl K, Silva AC, Hall SUS, Overdahl E, Kleinstreuer N, Strickland J, Allen D, Andrade CH, Muratov EN, Tropsha A.   +13 more
europepmc   +1 more source

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

Molecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola, Rafael Lopes Goncalves, Marin Truchi, Caroline Lacoux, Célia Scribe, Hugo Cadis, Laetitia Guardini, Sophie Bekisz, Marius Ilié, Paul Hofman, Georges Vassaux, Bernard Mari, Roger Rezzonico   +12 more
wiley   +1 more source

Replacement of animal testing by integrated approaches to testing and assessment (IATA): a call for in vivitrosi. [PDF]

Arch Toxicol, 2022
Caloni F, De Angelis I, Hartung T.
europepmc   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Mechanisms of altitude-driven mycotoxin variation in stored wheat: a metabolomic and transcriptomic approach

BMC Microbiology
The Alternaria fungus represents a significant threat to grain storage safety due to its production of mycotoxins, which pose serious risks to human health.
Na Wei, Jifeng Pu
doaj   +1 more source

Organ chips, organoids and the animal testing conundrum. [PDF]

Nat Rev Mater, 2021
Horejs C.
europepmc   +1 more source

TOXOPLASMA GONDII IN U.S. SWINE OPERATIONS: AN ASSESSMENT OF MANAGEMENT FACTORS [PDF]

Sera from hogs were analyzed using the modified direct agglutination test (MAT). Serum samples were collected from sows which were part of the National Animal Health Monitoring System (NAHMS) swine survey.
Arne HALLAM, Eric BUSH, James Kliebenstein, Jeffrey ZIMMERMAN, Sharon PATTON, Tanya ROBERTS, Xianfeng HU   +6 more
core   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

A step-by-step approach for assessing acute oral toxicity without animal testing for additives of quasi-drugs and cosmetic ingredients. [PDF]

Curr Res Toxicol, 2023
Kojima H, Nakada T, Yagami A, Todo H, Nishimura J, Yagi M, Yamamoto K, Sugiyama M, Ikarashi Y, Sakaguchi H, Yamaguchi M, Hirota M, Aizawa S, Nakagawa S, Hagino S, Hatao M.   +15 more
europepmc   +1 more source