Results 171 to 180 of about 1,812,118 (303)

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Beyond animal testing: An integrated framework for modern chemical hazard identification and risk assessment. [PDF]

Environ Sci Ecotechnol
Fan T, Yan Z, Feng C, Wu F.
europepmc   +1 more source

Tumor mutational burden as a determinant of metastatic dissemination patterns

Molecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal, Andrea Moreno‐Manuel, Miguel Salvadó‐Pertierra, Cristina Santos‐Vivas, Rebeca Sanz‐Pamplona   +4 more
wiley   +1 more source

Antibody-based alternatives to animal testing for toxin detection and antitoxin evaluation. [PDF]

Front Toxicol
Chang SH, Jang J, Yang W, Lee NK, Choi S, Jung HI, Kim W, Cha B, Yoon SJ, Noh JY, Lee J.   +10 more
europepmc   +1 more source

Advances in Non-Animal Testing Approaches towards Accelerated Clinical Translation of Novel Nanotheranostic Therapeutics for Central Nervous System Disorders. [PDF]

Nanomaterials (Basel), 2021
Lynch MJ, Gobbo OL.
europepmc   +1 more source

Animal Testing Alternative [PDF]

, 2020
openaire   +1 more source

The Uniformly Most Powerful Invariant Test for the Shoulder Condition in Point Transect Sampling [PDF]

Estimating population abundance is of primary interest in wildlife population studies. Point transect sampling is a well established methodology for this purpose.
Piero Quatto, Riccardo Borgoni
core  

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Can alternatives to animal testing yield useful information regarding biological mechanisms and drug discovery? [PDF]

J Orthop Translat
Gao Q, Chow SK, Shinohara I, Murayama M, Susuki Y, Morita M, Ma C, Goodman SB.   +7 more
europepmc   +1 more source

Targeting p38α in cancer: challenges, opportunities, and emerging strategies

Molecular Oncology, EarlyView.
p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley   +1 more source