Results 181 to 190 of about 809,866 (309)

Replacing Animal Testing with Stem Cell-Organoids : Advantages and Limitations. [PDF]

Stem Cell Rev Rep
Park G, Rim YA, Sohn Y, Nam Y, Ju JH.
europepmc   +1 more source

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

Molecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola, Rafael Lopes Goncalves, Marin Truchi, Caroline Lacoux, Célia Scribe, Hugo Cadis, Laetitia Guardini, Sophie Bekisz, Marius Ilié, Paul Hofman, Georges Vassaux, Bernard Mari, Roger Rezzonico   +12 more
wiley   +1 more source

Alternatives to animal testing to assess MASH drugs and hepatotoxicity. [PDF]

Hepatology
Brenner DA, Brenner DA.
europepmc   +1 more source

Innovative Human Three-Dimensional Tissue-Engineered Models as an Alternative to Animal Testing. [PDF]

Bioengineering (Basel), 2020
Bédard P, Gauvin S, Ferland K, Caneparo C, Pellerin È, Chabaud S, Bolduc S.   +6 more
europepmc   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Development of a multi-analysis model using an epithelial-fibroblast co-culture system as an alternative to animal testing. [PDF]

Environ Anal Health Toxicol
Kim MJ, Hwang HS, Choi JH, Yoo ES, Jang MI, Lee J, Oh SM.   +6 more
europepmc   +1 more source

European Regulatory Requirements for Veterinary Vaccine Safety and Potency Testing and Recent Progress Towards Reducing Animal Use

, 2011
R M Woodland
openalex   +1 more source

Developing evidence‐based, cost‐effective P4 cancer medicine for driving innovation in prevention, therapeutics, patient care and reducing healthcare inequalities

Molecular Oncology, EarlyView.
The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg, Joachim von Braun, Julio Celis, Anton Berns, Michael Baumann, Tit Albreht, Nancy Abou‐Zeid, Vanderlei Bagnato, Christian Brandts, Chien‐Jen Chen, Massimiliano di Pietro, Manjit Dosanjh, Thomas Dubois, Alexander Eggermont, Angelika Eggert, Ingemar Ernberg, Sara Faithfull, Johannes Förner, Stefan Fröhling, Manuel Heitor, Leroy Hood, Wei Jiang, Bengt Jönsson, Ravi Kannan, Maria Leptin, Su Li, Peter Lindgren, Douglas Lowy, Jun Ma, Alex Markham, Péter Nagy, Simon Oberst, M. Iqbal Parker, Danielle Rodin, Kevin Ryan, Joachim Schüz, Richard Sullivan, Josep Tabernero, Peter Turkson, Oliver Várhelyi, Harold Varmus, Chijie Wang, Elisabete Weiderpass, Nils Wilking   +43 more
wiley   +1 more source

Cell-Free Screening, Production and Animal Testing of a STI-Related Chlamydial Major Outer Membrane Protein Supported in Nanolipoproteins. [PDF]

Vaccines (Basel)
Mohagheghi M, Abisoye-Ogunniyan A, Evans AC, Peterson AE, Bude GA, Hoang-Phou S, Vannest BD, Hall D, Rasley A, Weilhammer DR, Fischer NO, He W, Robinson BV, Pal S, Slepenkin A, de la Maza L, Coleman MA.   +16 more
europepmc   +1 more source

Medical Records for Animals Used in Research, Teaching, and Testing: Public Statement from the American College of Laboratory Animal Medicine [PDF]

, 2007
Kathryn Field, Mark Bailey, L. L. Foresman, R. L. Harris, S. L. Motzel, R. A. Rockar, Guy C. Ruble, Mark A. Suckow   +7 more
openalex   +1 more source