Results 171 to 180 of about 923,548 (275)

Testing alternative designs for a roadside animal detection system using a driving simulator [PDF]

, 2015
Molly K. Grace, Daniel J. Smith, Reed F. Noss   +2 more
openalex   +1 more source

Targeting carbonic anhydrase IX/XII prevents the anti‐ferroptotic effect of stromal lactic acid in prostate carcinoma

Molecular Oncology, EarlyView.
In prostate carcinoma, lactic acid, secreted by highly glycolytic cancer‐associated fibroblasts, is imported into tumor cells through the MCT1 transporter and prevents RSL3 and erastin‐induced ferroptosis (A). Targeting of carbonic anhydrase IX/XII, the main extracellular pH regulators, in tumor and stromal cells reduces microenvironmental acidosis and
Elisa Pardella, Giuseppina Comito, Luigi Ippolito, Erica Pranzini, Marta Iozzo, Giulia Gangarossa, Francesca Virgilio, Silvia Bua, Alessio Nocentini, Giada Sandrini, Nicla Lorito, Marina Bacci, Gabriella Nesi, Pietro Spatafora, Sergio Serni, Claudiu T. Supuran, Andrea Morandi, Paola Chiarugi, Elisa Giannoni   +18 more
wiley   +1 more source

A European perspective on alternatives to animal testing for environmental hazard identification and risk assessment.

Regulatory toxicology and pharmacology : RTP, 2013
S. Scholz, E. Sela, L. Bláha, T. Braunbeck, M. Galay-burgos, M. García-Franco, J. Guinea, N. Klüver, K. Schirmer, K. Tanneberger, M. Tobor-Kapłon, H. Witters, S. Belanger, E. Benfenati, S. Creton, M. Cronin, R. Eggen, M. Embry, D. Ekman, A. Gourmelon, M. Halder, B. Hardy, T. Hartung, B. Hubesch, Dirk Jungmann, M. Lampi, L. Lee, M. Léonard, E. Küster, A. Lillicrap, T. Luckenbach, A. Murk, J. M. Navas, W. Peijnenburg, G. Repetto, E. Salinas, G. Schüürmann, H. Spielmann, K. Tollefsen, Susanne Walter-Rohde, G. Whale, J. Wheeler, M. Winter   +42 more
semanticscholar   +1 more source

Chemicals regulation and non-animal methods: displacing the gold standard [version 2; peer review: 2 approved]

Wellcome Open Research
Regulating industrial chemicals in foodstuffs and consumer products is a major aspect of protecting populations against health risks. Non-animal testing methods are an essential part of the radical change to the framework for toxicity testing that is ...
Annamaria Carusi
doaj  

Machine learning for identifying liver and pancreas cancers through comprehensive serum glycopeptide spectra analysis: a case‐control study

Molecular Oncology, EarlyView.
This study presents a novel AI‐based diagnostic approach—comprehensive serum glycopeptide spectra analysis (CSGSA)—that integrates tumor markers and enriched glycopeptides from serum. Using a neural network model, this method accurately distinguishes liver and pancreatic cancers from healthy individuals.
Motoyuki Kohjima, Yuko Takami, Ken Kawabe, Kazuhiro Tanabe, Chihiro Hayashi, Mikio Mikami, Tetsuya Kusumoto   +6 more
wiley   +1 more source

Airborne toxicological assessment: The potential of lung-on-a-chip as an alternative to animal testing

, 2022
Ko-Chih Lin, Chien-Mei Yen, Jia‐Wei Yang, Johnson Chung, G.-Y. Chen   +4 more
openalex   +1 more source

Beyond digital twins: the role of foundation models in enhancing the interpretability of multiomics modalities in precision medicine

FEBS Open Bio, EarlyView.
This review highlights how foundation models enhance predictive healthcare by integrating advanced digital twin modeling with multiomics and biomedical data. This approach supports disease management, risk assessment, and personalized medicine, with the goal of optimizing health outcomes through adaptive, interpretable digital simulations, accessible ...
Sakhaa Alsaedi, Xin Gao, Takashi Gojobori   +2 more
wiley   +1 more source

THE HEN'S EGG TEST - CHORIO-ALLANTOIC-MEMBRANE (HET -CAM) AND HAEMOLYSIS STUDY AS AN ALTERNATIVE TEST FOR OCCULAR IRRITANCY ANIMAL EXPERIMENTS (Draize Test) [PDF]

, 2018
Sadhana R Shahi Deepak G Wagh
openalex   +1 more source

Alternatives to the use of animals in research, education and testing

ALTEX, 2016
Maryanne Wangari Kagai, Josphat Ngonyo, Samuel Macharia Theuri   +2 more
openaire   +3 more sources

Comparative single‐cell transcriptomic profiling of patient‐derived renal carcinoma cells in cellular and animal models of kidney cancer

FEBS Open Bio, Volume 15, Issue 7, Page 1124-1143, July 2025.
We generated and characterized clear cell renal cell carcinoma models using the patient‐derived RCC243 cell line—including cell culture, orthotopic, and metastatic tumors—via single‐cell RNA‐sequencing for comparisons between models and patient tumor datasets.
Richard Huang, Lynn Kee, Alexander Gont, Jalna Meens, Fraser G. Ferens, Meredith S. Irwin, Laurie Ailles, Scott A. Yuzwa, Claire M. Robinson, Michael Ohh   +9 more
wiley   +1 more source