Results 51 to 60 of about 1,948,245 (257)

A microbial safari: finding evidence of Mycobacterium bovis DNA in soil from the Kruger National Park, South Africa

Microbiology Spectrum
The primary pathogen causing animal tuberculosis (TB), Mycobacterium bovis, can infect a wide range of mammals, including humans. This pathogen is considered endemic in the Kruger National Park (KNP), South Africa, where it threatens the health and ...
M. C. Matthews, M. E. M. Toorians, T. J. Davies, R. D. Stewart, W. J. Goosen, M. A. Miller   +5 more
doaj   +1 more source

Detection of live M. bovis BCG in tissues and IFN-γ responses in European badgers (Meles meles) vaccinated by oropharyngeal instillation or directly in the ileum

BMC Veterinary Research, 2019
Background Oral vaccination with Mycobacterium bovis Bacille of Calmette and Guerin (BCG) has provided protection against M. bovis to badgers both experimentally and in the field.
Sandrine Lesellier, Maria-Laura Boschiroli, Jacques Barrat, Christoph Wanke, Francisco J. Salguero, Waldo L. Garcia-Jimenez, Alex Nunez, Ana Godinho, John Spiropoulos, Simonette Palmer, Dipesh Dave, Paul Anderson, Jean-Marc Boucher, Krystel de Cruz, Sylvie Henault, Lorraine Michelet, Sonya Gowtage, Gareth A. Williams, Allan K. Nadian, Elodie Monchâtre-Leroy, Frank Boué, Mark A. Chambers, Céline Richomme   +22 more
doaj   +1 more source

OAF Blocks SIAH1‐Mediated Degradation of SCPX, a Therapeutic Strategy for MASLD

Advanced Science, EarlyView.
This study shows OAF directly binds to SCPX and inhibits its interaction with the E3 ligase SIAH1, thereby protecting SCPX from ubiquitin‐dependent degradation and stabilizing its levels. This OAF‐SCPX axis represents a novel pathway in lipid homeostasis, highlighting OAF as a promising therapeutic candidate for MASLD.
Zongxi Li, Jingyue Song, Kaili Ma, Shunan Tang, Shuqian Wang, Wenya Ji, Chen Lu, Ting Zhang, Huaping Zheng, Xiaowei Zheng, Shanshan Lai, Cheng Deng   +11 more
wiley   +1 more source

Upadacitinib Restrains the Pathogenic Fitness of CD4+ T Cells and Aberrant B Cell Programming in Optic Neuritis

Advanced Science, EarlyView.
Single‐cell profiling and functional perturbation reveal coordinated JAK1‐pSTAT3 downstream programs in optic neuritis, including MCL1‐dependent fitness of pathogenic CD4+ Tem cells and glycolysis‐linked, cholesterol‐sensitive B‐cell responses associated with RORA. Upadacitinib disrupts this reciprocal T‐B‐cell circuit and alleviates neuroinflammation,
Gengchen Jiang, Qi Jiang, Lian Han, Yue Peng, Xingyu Liu, Tong Yang, Hao Huang, Jiaying Liu, Yuan Gao, Hui Yang, Wenjun Zou, Zhaohuai Li, Wenru Su   +12 more
wiley   +1 more source

Retina and the tubercle Bacillus: Four decades of our journey and current understanding

Indian Journal of Ophthalmology, 2017
Tuberculosis continues to be a major pandemic with enormous public health implication. Involvement of ocular tissues in the form of tubercles, tuberculomas, panophthalmitis, and iris granulomas are well recognized as definitive manifestations of ...
Pradeep Venkatesh
doaj   +1 more source

Thermal Shifts Dominate Single‐Gene Responses to Transcription‐Targeting Antibiotics

Advanced Science, EarlyView.
Thermal shifts reshape bacterial responses to transcription‐targeting antibiotics. In E. coli, temperature can dominate antibiotic‐induced genome‐wide expression, particularly outside 30°C–39°C, through changes in adenosine triphosphate (ATP), nucleoid organization, and drug‐target engagement.
Rahul Jagadeesan, Amir M. Arsh, Vatsala Chauhan, Suchintak Dash, Pooja Ravaria, Andre S. Ribeiro   +5 more
wiley   +1 more source

Sarbecoviruses Suppress Innate Immunity by Recruiting PPM1A to Modulate STAT2 and ORF9b Phosphorylation

Advanced Science, EarlyView.
Sarbecovirus ORF9b recruits host phosphatase PPM1A to suppress innate immunity through dual mechanisms. PPM1A directly dephosphorylates ORF9b to sustain its activity and indirectly downregulates STAT2 phosphorylation to impair interferon signaling. Pharmacological inhibition of PPM1A restores antiviral responses and limits sarbecovirus replication ...
Lixiang Xie, Ziye Huang, Zhiyuan Zhang, Yiqiang Zhu, Xiaoqing Liu, Lei Wang, Tongyu Bi, Taizhen Liang, Jintao Lai, Meilin Hu, Guochang Qiu, Shiqi Xiao, Sen Liu, Yaoming Liu, Haiyue Rao, Tao Chen, Haojie Peng, Bin Zhang, Jia Tang, Qianying Li, Yaxin Li, Yuxin Hou, Weibo Yang, Hewei Jiang, Xiancai Ma   +24 more
wiley   +1 more source

AASLD practice guidance on drug, herbal, and dietary supplement–induced liver injury

, 2022
Hepatology, EarlyView.
Robert J. Fontana, Iris Liou, Adrian Reuben, Ayako Suzuki, M. Isabel Fiel, William Lee, Victor Navarro   +6 more
wiley   +1 more source

Self-study modules on tuberculosis 1-5 : Introduction [PDF]

Course #WB2556The Self-Study Modules on Tuberculosis is a series of educational modules designed to provide information about tuberculosis (TB) in a self-study format. The series consists of nine modules that are separated into two parts. The first part,

core   +1 more source

Development and evaluation of a triplex droplet digital PCR method for differentiation of M. tuberculosis, M. bovis and BCG

Frontiers in Microbiology
IntroductionTuberculosis, caused by Mycobacterium tuberculosis complex (MTBC), remains a global health concern in both human and animals. However, the absence of rapid, accurate, and highly sensitive detection methods to differentiate the major pathogens
Yao Qu, Yao Qu, Mengda Liu, Mengda Liu, Xiangxiang Sun, Xiangxiang Sun, Xiangxiang Sun, Yongxia Liu, Jianzhu Liu, Liping Hu, Zhiqiang Jiang, Fei Qi, Wenlong Nan, Wenlong Nan, Xin Yan, Xin Yan, Mingjun Sun, Weixing Shao, Jiaqi Li, Shufang Sun, Shufang Sun, Haobo Zhang, Haobo Zhang, Xiaoxu Fan, Xiaoxu Fan   +24 more
doaj   +1 more source