Results 41 to 50 of about 1,948,245 (257)

Ofatumumab in Myelin Oligodendrocyte Glycoprotein Antibody–Associated Disease: A Comparison With Rituximab

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To evaluate the efficacy and safety of ofatumumab in patients with myelin oligodendrocyte glycoprotein antibody–associated disease (MOGAD), and compare it with rituximab. Methods We conducted a single–center, observational study including 22 MOGAD patients treated with ofatumumab and 21 treated with rituximab.
Yuxin Fan, Lei Zhou, Jingzi ZhangBao, Hongmei Tan, Zhouzhou Wang, Chao Quan   +5 more
wiley   +1 more source

Animal models for COVID-19 and tuberculosis

Frontiers in Immunology, 2023
Respiratory infections cause tremendous morbidity and mortality worldwide. Amongst these diseases, tuberculosis (TB), a bacterial illness caused by Mycobacterium tuberculosis which often affects the lung, and coronavirus disease 2019 (COVID-19) caused by
Björn Corleis, Max Bastian, Donata Hoffmann, Martin Beer, Anca Dorhoi, Anca Dorhoi   +5 more
doaj   +1 more source

Detection and Molecular Characterization of 9000-Year-Old Mycobacterium tuberculosis from a Neolithic Settlement in the Eastern Mediterranean [PDF]

, 2008
Background: Mycobacterium tuberculosis is the principal etiologic agent of human tuberculosis. It has no environmental reservoir and is believed to have co-evolved with its host over millennia.
Eshed Vered, David E Minnikin, Besra, Gurdyal; id_orcid, Bargal, GK, Mark Spigelman, Bar-Gal Gila Kahila, Donoghue, HD, Hershkovitz Israel, Gernaey, AM, Bar-Gal, GK, Spigelman, M, Vered Eshed, Lemma, E, Galili Ehud, Gernaey Angela M., Minnikin David E., Spigelman Mark, Lemma Eshetu, Eshed, V, Eshetu Lemma, Charles L Greenblatt, Oona Y-C Lee, Lee Oona Y-C., Galili, E, Gurdyal S Besra, Donoghue Helen D., Greenblatt, CL, Besra, GS, Angela M Gernaey, Lee, Oona, Hershkovitz, I, Ehud Galili, Minnikin, DE, Besra Gurdyal S., Minnikin, David, Lee, OYC, Gila Kahila Bar-Gal, Helen D Donoghue, Israel Hershkovitz, Greenblatt Charles L.   +39 more
core   +1 more source

Advanced Materials for Biologics Delivery to Brain Tumors

Advanced Materials, EarlyView.
Material innovation is central to unlocking the therapeutic potential of biologics against many central nervous system diseases, including brain cancer. By engineering carriers with controlled transport, targeting, and release properties, advanced materials can overcome the blood–brain barrier and tumor microenvironment, improving the delivery of ...
Yuran Feng, Yuxue Cao, Maria Kavallaris, Taskeen Janjua, Amirali Popat   +4 more
wiley   +1 more source

Comparative pathology of experimental pulmonary tuberculosis in animal models

Frontiers in Veterinary Science, 2023
Research in human tuberculosis (TB) is limited by the availability of human tissues from patients, which is often altered by therapy and treatment. Thus, the use of animal models is a key tool in increasing our understanding of the pathogenesis, disease ...
Laura Hunter, Laura Hunter, Inés Ruedas-Torres, Inés Ruedas-Torres, Irene Agulló-Ros, Irene Agulló-Ros, Emma Rayner, Francisco J. Salguero   +7 more
doaj   +1 more source

The Natural Product Corramycin Acts as a DNA Gyrase Poison and Overcomes Fluoroquinolone Resistance in Mycobacterium tuberculosis

Advanced Science, EarlyView.
Corramycin, a myxobacterial natural product antibiotic, exhibits potent bactericidal activity against multidrug‐resistant Mycobacterium tuberculosis. The compound hijacks bacterial transporters such as BacA and OppABCD to enter the cell and inhibits DNA synthesis through a previously unrecognized mode of DNA gyrase poisoning, locking the enzyme in an ...
Franziska Fries, Jennifer Herrmann, Michael Dal Molin, Yaëlle Wormser, Timo Risch, Yunsheng Gao, Gareth Prosser, Francesca Gubellini, Ariel Mechaly, Joshua B. Wallach, Anthony Castro, Arka Banerjee, Sari Rasheed, Alexander Horn, Mathias Müsken, Michael Kurz, Lindsay Sonnenkalb, Viola Dreyer, Stefan Niemann, Sönke Andres, Dirk Schnappinger, Uli Kazmaier, Norbert Reiling, Rolf Müller, Jan Rybniker, Stéphanie Petrella   +25 more
wiley   +1 more source

A Rare De Novo Missense Mutation in IFT122 Confers a Genetic Susceptibility Factor of Idiopathic Pediatric Uveitis Via Trio‐based Whole‐Exome Sequencing

Advanced Science, EarlyView.
A rare de novo IFT122‐A773E variant is identified in idiopathic pediatric uveitis and shown to exacerbate retinal inflammation and barrier dysfunction. Mechanistically, the variant enhances IFT43 interaction, elevates calcium signaling, and activates the MEK/ERK/FRA1 axis, revealing a previously unrecognized cilia‐associated pathway that may increase ...
Qian Zhou, Jiaxing Huang, Yilin Wang, Xingran Li, Xianyang Liu, Lingyu Dai, Hongshun Li, Qingfeng Wang, Jiangyi Liu, Guannan Su, Wanyun Zhang, Yang Deng, Qingfeng Cao, Yujie Lai, Xiang Luo, Changwei Huang, Ling Chen, Shengping Hou, Peizeng Yang   +18 more
wiley   +1 more source

Tuberculose canina e sua importância em saúde pública Canine tuberculosis and its importance in public health

Revista de Saúde Pública, 1994
Relata-se um caso de uma família com diagnóstico de tuberculose, cujo cão também apresentava a enfermidade. Discute-se a importância do rastreamento epidemiológico animal em casos de tuberculose humana.The present paper describes tuberculosis in a family
Jane Megid, Ana Paula F.R.L. Bracarense, Antonio Carlos F. dos Reis, Domingos José Sturion, Lígia M.M. Martin, Sônia R. Pinheiro   +5 more
doaj   +1 more source

Experimental Mycobacterium microti Infection in Bank Voles (Myodes glareolus)

Microorganisms, 2022
Voles are maintenance hosts of Mycobacterium microti. In line with the goal to eradicate tuberculosis (TB) in livestock, the role of this mycobacteria needs to be assessed since it might interfere with current M. bovis/M.
Enric Vidal, Judit Burgaya, Lorraine Michelet, Claudia Arrieta-Villegas, Guillermo Cantero, Krystel de Cruz, Jennifer Tambosco, Michelle Di Bari, Romolo Nonno, Maria Laura Boschiroli, Bernat Pérez de Val   +10 more
doaj   +1 more source

Targeting the NR1D1–IGF2BP2–V‐ATPase Axis With Hybrid Nanovesicles Restores Macrophage Rhythms to Reverse Sepsis‐Induced Immunosuppression

Advanced Science, EarlyView.
Sepsis disrupts immune‐cell rhythms and weakens bacterial clearance. Biomimetic nanovesicles combining erythrocyte and inflammation‐activated macrophage membranes deliver siNR1D1 to dysfunctional macrophages, restoring the NR1D1–IGF2BP2–V‐ATPase pathway, circadian regulation, phagolysosomal acidification, and antimicrobial defense.
Lang Chen, Wenyi Lin, Lang Jiang, Xuehui Gao, Chenyan Yu, Jili Han, Zhenping Liu, Xuefeng Li, Mei He, Chang Li, Qilan Li, Chaoying Song, Jiqian Xu, You Shang   +13 more
wiley   +1 more source