Results 121 to 130 of about 3,673,245 (381)

Targeting the MDM2‐MDM4 interaction interface reveals an otherwise therapeutically active wild‐type p53 in colorectal cancer

Molecular Oncology, EarlyView.
This study investigates an alternative approach to reactivating the oncosuppressor p53 in cancer. A short peptide targeting the association of the two p53 inhibitors, MDM2 and MDM4, induces an otherwise therapeutically active p53 with unique features that promote cell death and potentially reduce toxicity towards proliferating nontumor cells.
Sonia Valentini, Giada Mele, Marika Attili, Maria Rita Assenza, Fulvio Saccoccia, Francesca Sardina, Cinzia Rinaldo, Roberto Massari, Nicola Tirelli, Alfredo Pontecorvi, Fabiola Moretti   +10 more
wiley   +1 more source

Caracterización clínico-epidemiológica de mordeduras en personas mayores en la provincia de los Andes, región de Valparaíso, Chile

ARS Medica, 2019
Introducción: las mordeduras constituyen un relevante problema de salud, con amplio espectro clínico, pudiendo causar la muerte. Existe escasa información del tema en personas mayores (PM).
Rocio Belen Salas Ramírez, Vania Villagra Castillo, Marisa Torres Hidalgo   +2 more
doaj  

Thermal proteome profiling and proteome analysis using high‐definition mass spectrometry demonstrate modulation of cholesterol biosynthesis by next‐generation galeterone analog VNPP433‐3β in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Elevated level of cholesterol is positively correlated to prostate cancer development and disease severity. Cholesterol‐lowering drugs, such as statins, are demonstrated to inhibit prostate cancer. VNPP433‐3β interrupts multiple signaling and metabolic pathways, including cholesterol biosynthesis, AR‐mediated transcription of several oncogenes, mRNA 5′
Retheesh S. Thankan, Elizabeth Thomas, Mehari M. Weldemariam, Puranik Purushottamachar, Weiliang Huang, Maureen A. Kane, Yuji Zhang, Nicholas Ambulos, Bi‐Dar Wang, David Weber, Vincent C. O. Njar   +10 more
wiley   +1 more source

De leones, águilas y liebres (y caballos y perros): bestiarios y enciclopedias naturales en el Lucidario de Sancho IV

Ítaca
El Lucidario es un diálogo entre un maestro y su discípulo compuesto bajo el auspicio de Sancho IV de Castilla entre 1293 y 1295. Escrito siguiendo la tradición escolástica de la literatura de quaestiones, el tratado dedica cerca de un tercio de sus 100 ...
Mario Cossío Olavide
doaj   +1 more source

Educación asistida con animales [PDF]

, 2018
A lo largo de nuestra historia existe la evidencia de que los animales han convivido cerca del ser humano aportando numerosos beneficios mejorado su calidad de vida.
Prieto Sánchez, Patricia
core  

Exploration of heterogeneity and recurrence signatures in hepatocellular carcinoma

Molecular Oncology, EarlyView.
This study leveraged public datasets and integrative bioinformatic analysis to dissect malignant cell heterogeneity between relapsed and primary HCC, focusing on intercellular communication, differentiation status, metabolic activity, and transcriptomic profiles.
Wen‐Jing Wu, Jianchao Wang, Fuqing Chen, Xuefeng Wang, Bin Lan, Ruyi Fu, Hong Wen, Fangfang Chen, Wei Hong, Tian‐Yu Tang, Ying He, Gang Chen, Jianyin Zhou, Hai‐Long Piao, Di Chen, Shu‐Yong Lin   +15 more
wiley   +1 more source

Cuando atacan los animales [PDF]

, 2000
Los cuentos de Alicia Erian han aparecido recientemente en Zoetrope y Nerve. Su primera colección de narrativa breve, The Brutal Language of Love, la publicará la editorial Villard el año próximo. Alicia Erian vive en brooklyn, Nueva York, con su marido,
Erian, Alicia
core   +1 more source

Escape from TGF‐β‐induced senescence promotes aggressive hallmarks in epithelial hepatocellular carcinoma cells

Molecular Oncology, EarlyView.
Chronic TGF‐β exposure drives epithelial HCC cells from a senescent state to a TGF‐β resistant mesenchymal phenotype. This transition is characterized by the loss of Smad3‐mediated signaling, escape from senescence, enhanced invasiveness and metastatic potential, and upregulation of key resistance modulators such as MARK1 and GRM8, ultimately promoting
Minenur Kalyoncu, Dilara Demirci, Sude Eris, Bengisu Dayanc, Ece Cakiroglu, Merve Basol, Merve Uysal, Gulcin Cakan‐Akdogan, Fang Liu, Mehmet Ozturk, Gökhan Karakülah, Serif Senturk   +11 more
wiley   +1 more source

INTRODUCCIÓN A LOS SISTEMAS ANIMALES [PDF]

, 2017
SÓLO VISIÓN ...
SANCHEZ SANCHEZ HERMILO
core  

I. On the classification of the fossil animals commonly named Dinosauria [PDF]

, 1888
H. G. Seeley
openalex   +1 more source