Results 61 to 70 of about 17,639 (264)
Uso de animales de experimentación en la investigación biomédica en Costa Rica
Acta Médica Costarricense, 2010 El progreso en la investigación médica y biológica ha dependido en gran medida del uso de animales experimentales Dada la importancia que históricamente han tenido los animales como reactivos biológicos en la investigación biomédica se consolidó la ...
Jorge Granados-Zúñiga
doaj
Leucine‐rich glioma inactivated 1 (LGI1) is a ganglioside‐binding protein
FEBS Letters, EarlyView.Neuronal hyperexcitability associated with a decrease/absence of the extracellular protein LGI1 has been suggested to be primarily due to the downregulation of Kv1 channel expression. The molecular mechanisms underlying this decrease have not yet been elucidated.
Kévin Debreux +7 more
wiley +1 more source
Metastatic niche shaped by host factors influences disseminated cancer cell fate
FEBS Letters, EarlyView.Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward +2 more
wiley +1 more source
Lysyl oxidase (LOX)‐mediated remodeling of the extracellular matrix
FEBS Letters, EarlyView.The lysyl oxidase (LOX) family of enzymes drives extracellular matrix remodeling by oxidizing collagen, elastin, and fibronectin, promoting covalent cross‐link formation. This activity regulates tissue architecture and mechanical properties, while its dysregulation contributes to fibrosis, cardiovascular disease, glaucoma, connective tissue disorders ...
Fernando Rodríguez‐Pascual +3 more
wiley +1 more source
Revista Educa UMCHEl presente artículo propone una serie de reflexiones sobre los efectos socio-subjetivos del acto de apodar en la trama de la interacción escolar. Particularmente, analiza una serie de términos despreciativos que utilizan jóvenes indígenas tales como ...
Elisa Martina De los Ángeles Sulca +1 more
doaj +1 more source
Smaller is better: nanobodies meet NMR
FEBS Letters, EarlyView.Nanobodies are single‐domain antigen‐binding fragments derived from camelid heavy chain antibodies. Their small size, high stability, and exceptional specificity make nanobodies uniquely useful probes for NMR studies of protein dynamics, transient conformational states, and protein–protein interactions.
Oleg Y. Dmitriev
wiley +1 more source
La alétheia de los gatos. Balthus, Rilke y el problema de lo “Abierto”
Areté, 2022 Este artículo toma como punto de partida la colaboración artística entre Rainer Maria Rilke y Balthazar Klossowski –Balthus– que vio la luz en la publicación del libro titulado Mitsou.
María del Carmen Molina Barea
doaj
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
Griot : Revista de Filosofia, 2021 Junto a las reprimendas de Diógenes el Perro, la filosofía de la amargura de Émile Cioran y el neo-Cinismo de Peter Sloterdijk, se conformaría –en opinión del autor- un linaje Cínico que habla por sí mismo, pese a sus diferencias “doctrinales”, de la supervivencia hasta hoy de este verdadero paria de la filosofía.
openaire +3 more sources