Results 51 to 60 of about 17,639 (264)

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Sociabilités animales [PDF]

Études rurales, 2012
Dans un article recent, Paul R. Ehrlich et Robert M. Pringle proposaient des mesures d’urgence pour endiguer l’erosion de la biodiversite a travers le monde, parmi lesquelles « un changement des attitudes humaines envers la nature » [2008 : 11 583]. Tandis que l’essentiel de leur programme s’adressait evidemment aux gouvernants, cette proposition s ...
openaire   +1 more source

Sobrecarga sistólica intermitente promove melhor desempenho miocárdico em animais adultos Sobrecarga sistólica intermitente promueve mejor desempeño miocárdico en animales adultos Intermittent systolic overload promotes better myocardial performance in adult animals

Arquivos Brasileiros de Cardiologia, 2010
FUNDAMENTO: A transposição corrigida das grandes artérias frequentemente evolui com disfunção ventricular direita. O preparo ventricular para a correção anatômica em pacientes adultos apresenta resultados desapontadores.
Leonardo Augusto Miana, Renato S. Assad, Maria C. D. Abduch, Guilherme Seva Gomes, Ananda Rigo Nogueira, Fernanda Santos Oliveira, Bruna Lopes Telles, Maria Teresa Souto, Gustavo J. Silva, Noedir A. G. Stolf   +9 more
doaj  

The woman and the Nature in Terra baixa by Àngel Guimerà, in the opera Tiefland by Eugen d'Albert and Rudolph Lothar and in the film Tiefland by Leni Riefenstahl

Revista de Filología Románica, 2014
This article studies the transposition of the Catalan rural play Terra baixa (Martha of the Lowlands) by Àngel Guimerà into the German Verismo oper and the film of the same name. Besides the typical peculiarities of each medium, it will be analized woman’
Maridès Soler
doaj   +1 more source

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

Animale

ANIMALIA organifatione viva, nervisfentiunt, percipiunt,fequeexarbítriomoventmotu poffibili. VIVENTIA fingula, in multiplicatione prodiga Natura, orditur a mimmis, generat in fluido, mcipit in ovi líquido, cum onme vivam ex ovo. OVUM intra Tunicas, fape includentes Albumen, continet Viíellum, cujus lateri emergenti infertum Puctum faliens, vegetans in ...
openaire   +3 more sources

(ce) qui touche e(s)t (ce) qui regarde Derrida. Lectura patética del “Têteà-tête” de Jacques Derrida entre el ver y el tocar

Revista de Filosofía Universidad Iberoamericana
Texto tardío publicado con motivo de una exposición de obras de Camilla Adami, “Tête-à-tête” de Jacques Derrida constituye un punto de convergencia temático alrededor de la cuestión del animal. En el presente artículo, con base en una traducción propia,
Elina López Marchat
doaj   +1 more source

Chiral separation of chloroalkanes with the chromatographic column onboard Martian rovers

FEBS Letters, EarlyView.
Computer image of the Rosalind Franklin Rover of ESA's ExoMars mission. ExoMars is scheduled to land on planet Mars in Oxia Planum in 2029. This area represents an interesting spot to look for biosignatures. Investigations of ExoMars include measurement on molecular chirality. We show that chiral chloroalkanes, that have been identified on Mars, can be
Asma Merzougui, Agnes Banreti, Armelle L. Ernst, Guillaume Leseigneur, Uwe J. Meierhenrich   +4 more
wiley   +1 more source