Results 71 to 80 of about 719,604 (316)

La categoría jurídica "sujeto/objeto" y su insuficiencia respecto de los animales. Especial referencia a los animales usados en laboratorios [PDF]

open access: yes, 2009
La experimentación con animales abre debates éticos de gran complejidad, que están en mayor o menor medida, recogidos en legislaciones que buscan regular el área.
Kemelmajer de Carlucci, Aída
core   +2 more sources

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

open access: yesMolecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova   +25 more
wiley   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

open access: yesMolecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano   +6 more
wiley   +1 more source

The woman and the Nature in Terra baixa by Àngel Guimerà, in the opera Tiefland by Eugen d'Albert and Rudolph Lothar and in the film Tiefland by Leni Riefenstahl

open access: yesRevista de Filología Románica, 2014
This article studies the transposition of the Catalan rural play Terra baixa (Martha of the Lowlands) by Àngel Guimerà into the German Verismo oper and the film of the same name. Besides the typical peculiarities of each medium, it will be analized woman’
Maridès Soler
doaj   +1 more source

Perception du changement climatique par les éleveurs de bovins des zones tropicales sèche et subhumide du Bénin : comparaison avec les données météorologiques

open access: yesCahiers Agricultures, 2020
Une fausse perception du changement climatique peut entraîner une absence d’adaptation ou une mauvaise adaptation, augmentant ainsi la vulnérabilité à ce changement.
Idrissou Yaya   +7 more
doaj   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

open access: yesMolecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos   +6 more
wiley   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang   +12 more
wiley   +1 more source

Uso de animales de experimentación en la investigación biomédica en Costa Rica

open access: yesActa Médica Costarricense, 2010
El progreso en la investigación médica y biológica ha dependido en gran medida del uso de animales experimentales Dada la importancia que históricamente han tenido los animales como reactivos biológicos en la investigación biomédica se consolidó la ...
Jorge Granados-Zúñiga
doaj  

(ce) qui touche e(s)t (ce) qui regarde Derrida. Lectura patética del “Têteà-tête” de Jacques Derrida entre el ver y el tocar

open access: yesRevista de Filosofía Universidad Iberoamericana
Texto tardío publicado con motivo de una exposición de obras de Camilla Adami, “Tête-à-tête” de Jacques Derrida constituye un punto de convergencia temático alrededor de la cuestión del animal. En el presente artículo, con base en una traducción propia,
Elina López Marchat
doaj   +1 more source

Prácticas de manejo y bienestar animal en la producción de ganado bovino de carne en Sur América [PDF]

open access: yes, 2016
El bienestar animal es el estado del individuo con respecto a sus tentativas por adaptarse al medio externo. En animales de producción el medio externo es impuesto por los ciclos productivos, instalaciones y manejo dado a los animales.
Caicedo Candela, Luis Alberto   +1 more
core  

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