Results 101 to 110 of about 685 (301)
Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source
Molecular Oncology, EarlyView.EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain +10 more
wiley +1 more source
Studia FilmoznawczeThis article describes animation techniques and their potential to break with what Marta Stańczyk refers to as the cinematic web of violence. Two film adaptations of the novel Watership Down by Richard Adams will serve as examples—a 1978 traditional ...
Adrianna Wójkiewicz
doaj +1 more source
Molecular Oncology, EarlyView.We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Formulation of the Impact of Competing Knowledge-Value Trends on the Political Theology of Ayatollah Javadi Amoli [PDF]
پژوهشنامه کلام تطبیقی شیعهAyatollah Abdullah Javadi Amoli is a contemporary thinker who is an expert in various fields of Islamic humanities, especially political theology. Due to his relative comprehensiveness in theology and processing of political theology issues, as well as ...
ali aqajani
doaj +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
The (Neo)colonial Sentimentality of 90 Day Fiancé and the Figure of the Heartless Filipina
LateralIn its depiction of interracial, international marriage, the reality television show 90 Day Fiancé has become an object of morbid fascination to US and global audiences alike.
Alyssa Manansala
doaj +1 more source
Relating to foetal persons: why women's Voices come first and last, but not alone in Abortion debates. [PDF]
Med Health Care Philos, 2023 Milford S.
europepmc +1 more source