Results 61 to 70 of about 15,188 (291)
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
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Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
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Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
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eTropic: electronic journal of studies in the tropicsSet at the beginning of the hot season in the Philippines, when heat starts to crawl on skin, the short fiction “The Boy with the Pet Dog” (“Ang Batang May Alagang Aso”) stages an encounter between the titular character and a young man from the province
Allan R. Derain +1 more
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Chimpanzee Rights: The Philosophers' Brief [PDF]
, 2018 In December 2013, the Nonhuman Rights Project (NhRP) filed a petition for a common law writ of habeas corpus in the New York State Supreme Court on behalf of Tommy, a chimpanzee living alone in a cage in a shed in rural New York (Barlow, 2017).
Andrews, Kristin +12 more
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Aggressive prostate cancer is associated with pericyte dysfunction
Molecular Oncology, EarlyView.Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero +11 more
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A dialogue among indigenous groups: the experience of two encounters mediated by the video
Revista de Antropologia, 1995 In this paper, Peter Riviére, deals with Lowland South American notions of transformation as presente is mythic narratives and cosmologies as well as in social practices. Human nature is understood as varied and intricated, this condition being expressed
Peter Riviere
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Finding Ferality in the Anthropocene: Marie Darrieussecq’s “My Mother Told Me Monsters Do Not Exist” [PDF]
, 2016 What will it take to undomesticate the world—to begin to loosen humanity’s tight grasp on the planet’s spaces, structures, resources, and populations? Marie Darrieussecq’s short story “My Mother Told Me Monsters Do Not Exist” describes the intrusion of ...
Sophia Booth Magnone
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Molecular Oncology, EarlyView.The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués +3 more
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The recognizable face of fear: Domestication and redemption of the animal monster in The Exorcist
Gragoatá, 2013 This article analyses the function of animal traits in the transformation from human to monster in the movie “The Exorcist”, based on the homonymous best-seller by William Peter Blatty.
Marcia Heloisa Amarante Gonçalves
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