Results 71 to 80 of about 2,912 (306)

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

A dimensão simbólica e espiritual da biodiversidade nas cosmologias indígenas e abordagens filosóficas (The symbolic and spiritual dimension of biological diversity in indigenous cosmologies approaches) - DOI: 10.5752/P.2175-5841.2010v8n17p11

Horizonte, 2010
Este trabalho propõe uma reflexão em torno da biodiversidade, a partir da crítica à política de conservação da diversidade biológica, estabelecida pela Convenção sobre Biodiversidade, considerando que ela se encontra impregnada de uma lógica utilitária e
Maristela Oliveira de Andrade
doaj  

Wilder powers: Morality and animality in tales of war and terror

, 2013
Among the figures of animality evoked in narratives of violence are the "beast" who perpetrates acts of brutality and the debased creature who is subjected to captivity, forced labor, or slaughter.
Langford, Jean M.
core   +1 more source

Poverty, Life and Animality in Heidegger’s Thought [PDF]

, 2012
El curso dictado por Heidegger en 1929 y publicado con el título Los conceptos fundamentales de la metafísica. Mundo, finitud y soledad se pregunta por la animalidad del animal.
Candiloro, Hernán, Candiloro, Hernan Javier   +1 more
core   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Bóg-człowiek, bóg-zwierzę. Zwierzęce twarze religii

Zoophilologica, 2015
The aim of this short article is to discuss the state of research in a field which attempts to combine animal studies with theology and religious studies, and to map its discourse, tentatively called “critical ecotheology” and construed as environmental ...
Alina Mitek-Dziemba
doaj  

Anthropocentrism and Two Phenomenological Approaches to Animal Life

Problemos
This article analyzes two phenomenological approaches to animal life in the context of criticism of anthropocentrism. The first part considers the question of anthropocentrism. Beginning with the posthumanist criticism of anthropocentrism as an ideology
Mintautas Gutauskas
doaj   +3 more sources

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Consciousness, Continuity and Responsibility: Toward a Stratified Relational Model of Human–Animal Difference

Philosophies
The intricate relationships between humans and animals have long shaped philosophical, cultural and scientific inquiry. This narrative review examines evolving conceptions of animal consciousness, agency and sentience within broader historical, ethical ...
João Miguel Alves Ferreira
doaj   +1 more source

Des animaux ordinaires ou étrangers ? Territoires bovins entre Woolf et Deleuze

Études Britanniques Contemporaines, 2015
Virginia Woolf’s modernist animals affected Deleuze and Guattari’s animal philosophy, as they describe in A Thousand Plateaus. This essay focuses on the significance of these references to Woolf’s aesthetics for Deleuzian philosophy, whilst also ...
Derek Ryan
doaj   +1 more source