Results 91 to 100 of about 2,912 (306)

Divagações quiméricas sobre os limites do humano: uma ode à monstruosidade

open access: yese-cadernos ces
As the title of this article states, my intent is to question the universality of the concept of humanity based on the conception of monstrosity, which is very much akin to that of animality.
Bruno Latini Pfeil
doaj   +1 more source

Animal Bodies, Colonial Subjects: (Re)Locating Animality in Decolonial Thought

open access: yes, 2014
In this paper, I argue that animal domestication, speciesism, and other modern human-animal interactions in North America are possible because of and through the erasure of Indigenous bodies and the emptying of Indigenous lands for settler-colonial ...
Billy-Ray Belcourt
core   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

open access: yesMolecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain   +10 more
wiley   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

open access: yesMolecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu   +10 more
wiley   +1 more source

Bestial Traces : Race, Sexuality, Animality

open access: yes, 2012
In contemporary race and sexuality studies, the topic of animality emerges almost exclusively in order to index the dehumanization that makes discrimination possible.
Peterson, Christopher (R14092)
core  

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

open access: yesMolecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata   +10 more
wiley   +1 more source

La chèvre ou la femme. Parentés de lait entre animaux et humains au Moyen Âge.

open access: yesImages Re-Vues, 2012
This article launches an investigation about images of interspecies breast-feeding in the Middle Ages. Thought as a transmission of humors and features, milk kinship was higlhy rated at the time, and was often questioned about fostering practices. Breast-
Pierre-Olivier Dittmar   +2 more
doaj   +1 more source

Animality: Animals and Art

open access: yes, 2016
Press release extract: Why have animals not been subject of greater interest in contemporary conversations and historical discourses in the arts? With this question as a premise, ANIMALITY examines how an artistic and theoretical impetus might be formed ...
Jones, Sarah
core  

Circulating tumor cell viability during and after radiotherapy mirrors treatment response in cancer patients

open access: yesMolecular Oncology, EarlyView.
Radiotherapy (RT) response depends on the DNA repair capacity of tumor and host cells. We show that circulating tumor cell (CTC) counts and apoptosis rates before and after RT predict treatment response and outcome, which can be accessed via easily accessible liquid biopsy approaches. Created in BioRender. Wikman, H.
Yvonne Goy   +10 more
wiley   +1 more source

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