Results 81 to 90 of about 2,912 (306)
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Material Realist Texturality in Daisy Johnson’s Everything Under
Études Britanniques ContemporainesPremised in material ecocriticism (Alaimo, Neimanis, Sullivan, Armiero) and environmental narratology (Caracciolo), this study focuses on Daisy Johnson’s novel Everything Under (2018) and various manifestations of fluidity in it—of water, body, identity,
Julia Kuznetski
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Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source
Sillages Critiques, 2016 This article analyses the analogies between Howard Barker's theatre of Catastrophe and the abject as defined by Julia Kristeva in Powers of Horrors through the study of Found in the Ground, a play where there are many animals on the stage.
Eléonore Obis
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CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source
Une signification nouvelle. Le riflessioni sull'animalità del "primo" Merleau-Ponty
Rivista Internazionale di Filosofia e Psicologia, 2016 The purpose of this article is to examine Merleau-Ponty’s early analysis on animality, particularly referring to his first work The Structure of Behaviour. The article focuses on the review of notions like “behaviour” and “gestalt” and on the analysis of
Lucia Zaietta
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Molecular Oncology, EarlyView.Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau +8 more
wiley +1 more source
Les « amazoones », des chimères du mouvement antispéciste ?
Glad!Defined as a syncretism between feminism and antispeciesism, the femalist current aims to hybridize the two struggles to form a single one in defense of all “females”.
Nolwenn Veillard
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Tracing the Animal in the Human
Humanimalia, 2015 Christopher Peterson. Bestial Traces: Race, Sexuality, Animality. New York: Fordham University Press, 2013. 208 pp. $75 hc, $24 pb.
Chloe Diamond-Lenow
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KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source