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Disease-resistant genetically modified animals.
Revue scientifique et technique (International Office of Epizootics), 2005Infectious disease adversely affects livestock production and animal welfare, and has impacts upon both human health and public perception of livestock production. The authors argue that the combination of new methodology that enables the efficient production of genetically-modified (GM) animals with exciting new tools to alter gene activity makes the ...
C B A, Whitelaw, H M, Sang
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Genetically Modified Animal Organs for Human Transplantation
World Journal of Surgery, 1997AbstractThe major barrier to successful discordant xenogeneic organ transplantation is the phenomenon of hyperacute rejection (HAR). Hyperacute rejection results from the deposition of highâtiter preformed antibodies that activate serum complement on the luminal surface of the vascular endothelium, leading to vessel occlusion and graft failure within ...
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Renal Tubular Cells Cultured from Genetically Modified Animals
Nephron Experimental Nephrology, 1999The culture of renal tubular cells from genetically modified animals opens the opportunity of biochemical, cell biology and physiological studies under strictly controlled conditions. Either primary cultures or cell lines can be used. Through two examples of primary cultures of proximal tubular cells obtained from knock-out mice, important information ...
G, Friedlander +3 more
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Genetically modified animals in molecular stroke research
2004Brain damage induced by focal interruption of blood flow can be differentiated in two pathophysiologically different categories: a hemodynamic type of injury, resulting in primary necrotic brain damage, and a molecular type of injury which leads to delayed or secondary brain injury [15].
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[Applications of genetically modified animals].
Journal de la Societe de biologie, 2010The first transgenic animals, mice, were obtained in 1980. The techniques of gene transfer had to be adapted to obtain transgenic animals with an acceptable yield in about fifteen species. When the yield is low (low rate of random integration and targeted integration via homologous recombination), genetic modifications must be achieved in intermediate ...
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Special issue :Genetically modified animals. Introduction
2009International ...
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