Results 261 to 270 of about 175,605 (302)
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2012
AbstractThis article considers the extraordinary ways in which it is now possible to alter animals and to create new life forms by transgenesis and by the creation of hybrids and chimeras. Transgenic animals are created by transferring genes from one species to another.
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AbstractThis article considers the extraordinary ways in which it is now possible to alter animals and to create new life forms by transgenesis and by the creation of hybrids and chimeras. Transgenic animals are created by transferring genes from one species to another.
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Genetically Modified Animals and Pharmacological Research
2010This chapter reviews the use of genetically modified animals and the increasingly detailed knowledge of the genomes of the domestic species. The different approaches to genetic modification are outlined as are the advantages and disadvantages of the techniques in different species.
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The program for phenotyping of genetically modified animals at AstraZeneca
Experimental and Toxicologic Pathology, 2006Genetically modified mice offer a wide range of possibilities in preclinical drug discovery, e.g. for use in target identification, target validation and disease model generation. However, genomic modification and alteration in gene expression may cause unpredicted phenotypic alterations in the organism other than the intended ones.
Anna-Lena, Berg, Mohammad, Bohlooly-Y
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Animal models of arrhythmia: classic electrophysiology to genetically modified large animals
Nature Reviews Cardiology, 2019Arrhythmias are common and contribute substantially to cardiovascular morbidity and mortality. The underlying pathophysiology of arrhythmias is complex and remains incompletely understood, which explains why mostly only symptomatic therapy is available.
Sebastian Clauss +9 more
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Genetically Modified Animal Organs for Human Transplantation
World Journal of Surgery, 1997AbstractThe major barrier to successful discordant xenogeneic organ transplantation is the phenomenon of hyperacute rejection (HAR). Hyperacute rejection results from the deposition of high‐titer preformed antibodies that activate serum complement on the luminal surface of the vascular endothelium, leading to vessel occlusion and graft failure within ...
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Environmental safety issues for genetically modified animals
Journal of Animal Science, 1993Organisms modified by the techniques of modern biotechnology may differ significantly from normal organisms or organisms modified by other methods. Before transgenic organisms are introduced into the environment, the potential environmental effects should be assessed.
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Genetically modified animals in molecular stroke research
2004Brain damage induced by focal interruption of blood flow can be differentiated in two pathophysiologically different categories: a hemodynamic type of injury, resulting in primary necrotic brain damage, and a molecular type of injury which leads to delayed or secondary brain injury [15].
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[Applications of genetically modified animals].
Journal de la Societe de biologie, 2010The first transgenic animals, mice, were obtained in 1980. The techniques of gene transfer had to be adapted to obtain transgenic animals with an acceptable yield in about fifteen species. When the yield is low (low rate of random integration and targeted integration via homologous recombination), genetic modifications must be achieved in intermediate ...
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