Results 21 to 30 of about 6,610,213 (244)

Dose translation between laboratory animals and human in preclinical and clinical phases of drug development

Drug development research (Print), 2018
Preclinical Research ...
Anroop B Nair, M. Morsy, S. Jacob
semanticscholar   +1 more source

The rabbit gingival tissue response to retraction liquids and tetrahydrozoline [PDF]

Vojnosanitetski Pregled, 2014
Backround/Aim. Retraction agents for temporary vertical and lateral suppression of gingival tissue as well as bleeding control and fluid flow in the gingival sulcus are expected to have maximal efficiency without irreversible damage of local ...
Kostić Ivan, Mihailović Dragan, Najman Stevo, Stojanović Sanja, Kostić Milena   +4 more
doaj   +1 more source

Development of a sensitive and specific xMAP assay for detection of antibodies against infectious laryngotracheitis and bronchitis viruses

Virology Journal, 2018
Background A serological method to simultaneously detect antibodies against infectious laryngotracheitis virus (ILTV) and infectious bronchitis virus (IBV) is imperative for the differential diagnosis and evaluation of antibodies titers after vaccination.
Huanan Wang, Feng Cong, Jianchi Guan, Li Xiao, Yujun Zhu, Yuexiao Lian, Ren Huang, Meili Chen, Pengju Guo   +8 more
doaj   +1 more source

Enrichment for Laboratory Zebrafish—A Review of the Evidence and the Challenges

Animals, 2021
Simple Summary The zebrafish is one of the most commonly used animals in scientific research, but there remains a lack of consensus over good practice for zebrafish housing and care.
Chloe Stevens, Barney T. Reed, P. Hawkins   +2 more
semanticscholar   +1 more source

Imidacloprid as reproductive toxicant and endocrine disruptor: investigations in laboratory animals

Arhiv za Higijenu Rada i Toksikologiju, 2018
Imidacloprid, a neonicotinoid insecticide, has been used worldwide due to its selective toxicity for insects. Its residues may enter the food chain, which is why it is important to investigate the potential adverse effects of imidacloprid exposure.
A. Mikolić, I. Karačonji
semanticscholar   +1 more source

Development of a real-time loop-mediated isothermal amplification assay for detection of porcine circovirus 3

BMC Veterinary Research, 2019
Background Porcine circovirus type 3 (PCV3) is an emerging circovirus species, that has been reported in major pig-raising countries including the United States, China, South Korea, Brazil, Spain, and Poland.
Huanan Wang, Xiangnan Liu, Fanwen Zeng, Tongyuan Zhang, Yuexiao Lian, Miaoli Wu, Li Xiao, Yujun Zhu, Yu Zhang, Meili Chen, Ren Huang, Manlin Luo, Feng Cong, Pengju Guo   +13 more
doaj   +1 more source

Development of a novel humanized mouse model for improved evaluation of in vivo anti-cancer effects of anti-PD-1 antibody

Scientific Reports, 2021
Immune checkpoint inhibitors (ICIs) have revolutionized the treatment of cancer in the clinic. Further discovery of novel drugs or therapeutic protocols that enhance efficacy requires reliable animal models that recapitulate human immune responses to ICI
Ikumi Katano, Asami Hanazawa, Iyo Otsuka, Takuya Yamaguchi, Misa Mochizuki, Kenji Kawai, Ryoji Ito, Motohito Goto, Takahiro Kagawa, Takeshi Takahashi   +9 more
doaj   +1 more source

Identificationof a novel linear epitope on the porcine reproductive and respiratory syndrome virus nucleocapsid protein, as recognized by a specific monoclonal antibody

Frontiers in Immunology, 2023
IntroductionPorcine reproductive and respiratory syndrome virus (PRRSV) remains one of the most threatening pathogens of swine. The nucleocapsid (N) protein is the major structural protein of the virus and has been used as a PRRSV diagnostic antigen due ...
Yuening Cheng, Miaoli Wu, Li Xiao, Mengdi Zhang, Bihong Huang, Feng Cong, Li Yi   +6 more
doaj   +1 more source

Isolation and characterization of Bordetella pseudohinzii in mice in China

Animal Models and Experimental Medicine, 2019
We report on the first detection and isolation of B. pseudohinzii (Bordetella pseudohinzii) in laboratory mice in China. Forty‐one B. pseudohinzii strains were isolated from 3094 mice in 33 different laboratory animal facilities in southern China.
Lei Ma, Shuwu Huang, Yinzhu Luo, Fangui Min, Lifang He, Meiling Chen, Jinchun Pan, Yu Zhang, Jing Wang   +8 more
doaj   +1 more source

Prediction of Compound Synthesis Accessibility Based on Reaction Knowledge Graph

Molecules, 2022
With the increasing application of deep-learning-based generative models for de novo molecule design, the quantitative estimation of molecular synthetic accessibility (SA) has become a crucial factor for prioritizing the structures generated from ...
Baiqing Li, Hongming Chen
doaj   +1 more source