Results 101 to 110 of about 135,135 (309)

ERK‐Mediated Phosphorylation of YAP Defines a Noncanonical FGF Signaling Mechanism in Stem Cells

Advanced Science, EarlyView.
With a powerful combination of in vivo, ex vivo, and in vitro models, the authors highlight a novel FGF‐ERK signaling regulation of YAP at the S128 site in neural crest‐derived stem cells. This study opens exciting new directions in stem cell biology and craniofacial biology, paving the way for potential innovations in the treatment of craniofacial ...
Xiaolei Zhao, Shannon Erhardt, Li Tang, Xiaotong Chen, Stephen M Farmer, Zixiu Cheng, Wen Chen, Ella Ziyuan Lu, Kihan Sung, Chang‐Ru Tsai, Mingjie Zheng, Sheng Zhang, Yang Liu, Jianxin Wang, Min Li, James F Martin, Jun Wang   +16 more
wiley   +1 more source

Surfactant therapy of newborn rabbits impairs lung macrophage bactericidal activity

, 1988
Because in vitro studies indicate that pulmonary alveolar macrophages (PAM's) filled with phospholipid vesicles have depressed microbicidal capacity, we tested the intrapulmonary bactericidal activity of newborn PAM's after surfactant treatment.
C. T. Barrett, M. P. Sherman, E. E. Aeberhard, J. B. D'Ambola   +3 more
core   +1 more source

Survival of a newborn from a pregnant woman with rabies infection [PDF]

, 2016
Background: Rabies is very common in People's Republic of China. Each year thousands of people die because of this disease, but rabies diagnosed in pregnancy is very rare.
Chen, Qiao Ge, Lam, Alfred, Jiang, Peng, Qu, Zhen Yu, Li, Guo-Wei, Liu, Chang   +5 more
core   +1 more source

GATA4‐Driven Transcription of HtrA1 Promotes Cellular Senescence in Ménière's Disease and Age‐Related Audio‐Vestibular Dysfunction

Advanced Science, EarlyView.
This study identifies the HDAC6/GATA4/HtrA1 axis as a critical driver of cellular senescence in the inner ear. GATA4 nuclear translocation, facilitated by HDAC6 downregulation, transcriptionally activates HtrA1, promoting hair cell senescence, SASP, and audio‐vestibular dysfunction in models of Ménière's disease and age‐related audio‐vestibular ...
Na Zhang, Na Li, Yan Wang, Jing Zhang, Jiahui Liu, Lei Chen, Yongdong Song, Yurong Mu, Yuechen Han, Yafeng Lyu, Xiaofei Li, Hanyue Wang, Jing Wang, Yao Lu, Zhaomin Fan, Daogong Zhang, Haibo Wang   +16 more
wiley   +1 more source

Private heat for public warmth: how huddling shapes individual thermogenic responses of rabbit pups [PDF]

, 2012
<p><b>Background:</b> Within their litter, young altricial mammals compete for energy (constraining growth and survival) but cooperate for warmth.
Caroline Gilbert, André Ancel, Blanc, S., Dominic J McCafferty, Ancel, André, Stéphane Blanc, Mccafferty, Dominic J, Giroud, Sylvain, Ancel, A., Gilbert, Caroline, Giroud, S., Blanc, Stéphane, Gilbert, C., Sylvain Giroud, McCafferty, D.J.   +14 more
core   +1 more source

A Central Somatic Transmission Mediates Proprioceptive Facilitation of Muscle Pain

Advanced Science, EarlyView.
Zhang et al. uncover a novel central mechanism for persistent muscle pain, in which TRPA1 sensitization in MeV proprioceptive neurons enhances somatic secretion. This, in turn, disinhibits descending pain control from neighboring noradrenergic locus coeruleus neurons via local GABAergic circuits, thereby promoting inflammatory muscle pain.
Xiaoyu Zhang, Jiale Yang, Xi Wu, Jie Li, Fujian Lu, Yiman Li, Xingyu Du, Rong Huang, Jamila Asgar, Jing Wang, Ke Ren, Feipeng Zhu, Changhe Wang, Yehua Gan, Feng Wei, Zhuan Zhou   +15 more
wiley   +1 more source

ВЛИЯНИЕ НА ТЕХНОЛОГИЧНИЯ РЕЖИМ НА ХРАНЕНЕ ПРИ НОВОРОДЕНИ ТЕЛЕТА ВЪРХУ НЯКОИ КРЪВНИ ПОКАЗАТЕЛИ ПРЕЗ ЗИМНИЯ СЕЗОН

Животновъдни науки, 2013
We studied the influence of two different technological regimes of feeding and raising in newborn calves during the winter on some blood indexes, namely total protein, hemoglobin, hematocrit, erythrocyte count, cortisol and pH.
КРАСИМИР КРЪСТЕВ, СВЕТЛАНА ГРИГОРОВА   +1 more
doaj  

Comparison of carotid sinus baroreceptor sensitivity in newborn and adult rabbits

, 1982
The impulse activity in single baroreceptor fibers of the carotid sinus nerve to the carotid sinus was studied in newborn rabbits (9--11 days old) during nonpulsatile perfusion of in vitro carotid sinus preparations.
K. Nishi, E. Tomomatsu
core   +1 more source

Zinc Exposure Causes Disulfidptosis to Induce Miscarriage by Up‐Regulating GATA1/METTL1/SLC7A11 Axis

Advanced Science, EarlyView.
Zn exposure up‐regulates GATA1, promoting GATA1‐mediated METTL1 and SLC7A11 transcription. It also enhances METTL1‐mediated m7G modification on SLC7A11 mRNA, increasing SLC7A11 mRNA stability. Ultimately, Zn exposure up‐regulates SLC7A11 at both transcriptional and post‐transcriptional levels, causing disulfidptosis. Knockdown of murine Slc7a11, Gata1,
Wenxin Huang, Yi Sun, Yanxin Wang, Haijun Yan, Xiaoping Yue, Weidong Wu, Xueyu Chen, Jinfang Zhang, Yanbing Lin, Qiong Lei, Nan Ji, Shuaishuai Xing, Liqin Zeng, Qingzheng Kang, Depeng Zhao, Geng Guo, Huidong Zhang   +16 more
wiley   +1 more source

Targeting the PDK1/c‐Myc/SOX10 Signaling in Oligodendrocytes Alleviates Neuropathic Pain

Advanced Science, EarlyView.
This work reveals that oligodendrocyte homeostasis, mediated by PDK1, is a critical determinant of neuropathic pain (NPP) pathogenesis. Disruption of PDK1 in oligodendrocytes impairs SOX10‐dependent myelination programs through c‐Myc accumulation, leading to disrupted myelination and the pathophysiology of NPP.
Pingping Qiao, Lifang Guo, Guochao Yang, Chaoli Huang, He Wang, Jian‐Jun Yang, Guiquan Chen, Yimin Hu   +7 more
wiley   +1 more source