Results 121 to 130 of about 3,919,853 (296)

A study of the transference between empathy towards companion animals and empathy towards humans in children [PDF]

open access: yes, 2000
Plan AViolence in our society is a growing concern. There is evidence of increasing violent behavior in young children. Problems such as teasing and schoolyard bullying have turned into vicious attacks and even murder. Professionals and lay persons alike
Lind, Mary A.
core  

Monkeypox in animals [PDF]

open access: yes
Updated August 17, 2022Monkeypox is a zoonotic disease, meaning that it can spread between animals and people, and is caused by Monkeypox virus, an Orthopoxvirus. While the animal reservoir is unknown, small mammals (e.g.

core   +2 more sources

Mixed‐class J‐domain protein scaffolds promote expanded aggregate handling and multivalent Hsp70 engagement during functional disaggregase assembly

open access: yesFEBS Letters, EarlyView.
Protein aggregates threaten proteostasis and cell health. In human cells, Hsp70–J‐domain protein‐based disaggregases remove aggregates, but how they assemble remains unclear. Our biochemical findings show that DNAJA2‐ and DNAJB1‐containing disaggregase scaffolds enhance luciferase aggregate targeting, and that Hsp70 recruitment by both J‐domain ...
Anna Szlachcic, Nadinath B. Nillegoda
wiley   +1 more source

Hypergraph animals

open access: yesPhysical Review E
Here we introduce simple structures for the analysis of complex hypergraphs, hypergraph animals. These structures are designed to describe the local node neighbourhoods of nodes in hypergraphs. We establish their relationships to lattice animals and network motifs, and we develop their combinatorial properties for sparse and uncorrelated hypergraphs ...
openaire   +3 more sources

Reconstructing enzyme evolution by protein engineering

open access: yesFEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler   +2 more
wiley   +1 more source

A time-space Bayesian regression model of rabies cases in the animal population of Kazakhstan (2013–2023)

open access: yesFrontiers in Veterinary Science
IntroductionDespite its endemic status and socioeconomic impacts, the spatial-temporal variation in rabies risk and its underlying determinants in Kazakhstan animal populations remain poorly understood.
Alberto Gomez-Buendia   +9 more
doaj   +1 more source

Decoding the dynamic extracellular matrix in cancer—3D models and bioscaffolds rewire the rules of tumor progression

open access: yesFEBS Letters, EarlyView.
Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani   +3 more
wiley   +1 more source

THE FINAL (MISSIONS) FRONTIER: EXTRATERRESTRIALS, EVANGELISM, AND THE WIDE CIRCLE OF HUMAN EMPATHY

open access: yesZygon, 2019
The possible existence of extraterrestrials has provoked more than five centuries of theological speculation on how these beings, if they exist, relate to God.
doaj   +2 more sources

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

open access: yesFEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi   +6 more
wiley   +1 more source

AscF in the mycobacterial CIII–CIV supercomplex lacks metal and nucleotide binding but links malate oxidation to respiration

open access: yesFEBS Letters, EarlyView.
The mycobacterial CIII‐CIV respiratory supercomplex is an obligate assembly, encompassing several subunits of unknown functions. We have characterized the intracellular subunit AscF, and show that it is unlikely to be a sensor for metals or nucleotides, but is required for growth on nonfermentable energy sources, and likely works as an adapter for ...
Eni Rile   +8 more
wiley   +1 more source

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