Results 111 to 120 of about 373,177 (393)

Role of membrane ion transport proteins in cerebral ischemic damage.

Frontiers in Bioscience, 2007
Loss of ion homeostasis plays a central role in pathogenesis of ischemic cell damage. Ischemia-induced perturbation of ion homeostasis leads to intracellular accumulation of Ca2+ and Na+ and subsequent activation of proteases, phospholipases, and ...
D. Kintner, Yanping Wang, Dandan Sun
semanticscholar   +1 more source

Intraoral Drug Delivery: Bridging the Gap Between Academic Research and Industrial Innovations

Advanced Functional Materials, EarlyView.
Intraoral drug delivery offers a promising route for systemic and localized therapies, yet challenges such as enzymatic degradation, limited permeability, and microbial interactions hinder efficacy. This figure highlights innovative strategies—mucoadhesive materials, enzyme inhibitors, and permeation enhancers—to overcome these barriers.
Soheil Haddadzadegan, Simona Summonte, Fabrizio Ricci, Matthias Sandmeier, Andreas Bernkop‐Schnürch   +4 more
wiley   +1 more source

TSPO interacts with VDAC1 and triggers a ROS-mediated inhibition of mitochondrial quality control [PDF]

, 2014
The 18-kDa TSPO (translocator protein) localizes on the outer mitochondrial membrane (OMM) and participates in cholesterol transport. Here, we report that TSPO inhibits mitochondrial autophagy downstream of the PINK1-PARK2 pathway, preventing essential ...
Anholt R, Daniel East, Decaudin D, Garnier M, Gatliff J, Hirsch JD, James Crosby, Jemma Gatliff, Krueger KE, Li H, Michelangelo Campanella, Miettinen H, Okatsu K, Ozawa K, Papadopoulos V, Peter Parker, Robert Harvey, Rosella Abeti, Seneviratne MS, Sileikyte J, Snyder SH, Tamse CT, William Craigen   +22 more
core   +2 more sources

Saccharomyces cerevisiae: First Steps to a Suitable Model System To Study the Function and Intracellular Transport of Human Kidney Anion Exchanger 1

mSphere, 2020
Saccharomyces cerevisiae has been frequently used to study biogenesis, functionality, and intracellular transport of various renal proteins, including ion channels, solute transporters, and aquaporins.
Hasib A. M. Sarder, Xiaobing Li, Charlotta Funaya, Emmanuelle Cordat, Manfred J. Schmitt, Björn Becker   +5 more
doaj   +1 more source

Dynamics of Phosphate Transport by the Anion-specific Outer Membrane Protein OprP [PDF]

Biophysical Journal, 2009
The outer membrane protein P (OprP) from Pseudomonas aeruginosa forms a water-filled channel which has an enhanced selectivity for anions, especially phosphates. The structure of this homotrimeric protein (PDB code 2O4V) reveals three positively charged loops (L3, L5, and T7) which are folded into the lumen and are suggested to funnel anions into the ...
Prapasiri Pongprayoon, Elizabeth Jayne Wallace, Mark S.P. Sansom   +2 more
openaire   +2 more sources

Double Cross‐Linked Hydrogel for Intra‐articular Injection as Modality for Macrophages Metabolic Reprogramming and Therapy of Rheumatoid Arthritis

Advanced Functional Materials, EarlyView.
A hydrogel for intra‐articular injection for the treatment of rheumatoid arthritis (RA) is formulated and comprehensively studied. After administration, the hydrogel induces a metabolic reprogramming of immunometabolism of macrophages to trigger fatty acid oxidation subsequently inducing polarization of anti‐inflammatory M2 macrophages. This results in
Yutong Song, Valentin A. Milichko, Ziqiao Ding, Wen Li, Bei Kang, Yunsheng Dou, Sona Krizkova, Zbynek Heger, Nan Li   +8 more
wiley   +1 more source

Ion Transport Processes of Crustacean Epithelial Cells

, 1999
Epithelial cells of the gut, antennal glands, integument, and gills of crustaceans regulate the movements of ions into and across these structures and thereby influence the concentrations of ions in the hemolymph.
Ahearn, Gregory A., Aslamkhan, Amy, Brown, Richard J., Duerr, Jeff, Killebrew, Deirdre A., Zhuang, Zhenpeng   +5 more
core  

Molecular characterization of an anion pump. The ArsB protein is the membrane anchor for the ArsA protein [PDF]

, 1990
R-factor mediated bacterial resistance to arsenical salts occurs by active extrusion of the toxic oxyanions from cells of gram negative bacteria. The ars operon of the conjugative plasmid R773 encodes an anion pump.
Rosen, Barry P., Tisa, Louis S.
core   +1 more source

Unidirectional Reconstitution into Detergent-destabilized Liposomes of the Purified Lactose Transport System of Streptococcus thermophilus [PDF]

, 1996
The lactose transport protein (LacS) of Streptococcus thermophilus was amplified to levels as high as 8 and 30% of total membrane protein in Escherichia coli and S. thermophilus, respectively.
Henderson, Peter J.F.,, Knol, Jan,, Leblanc, Gérard,, Liang, Wei-Jun,, Poolman, Bert,, Veenhoff, Liesbeth,   +5 more
core   +2 more sources

Transcobalamins I and II as natural transport proteins of vitamin B12.

Journal of Clinical Investigation, 1975
There are two conflicting theories of how plasma vitamin B12 (B12) is transported in man: (a) by two distinct transport proteins, transcobalamins I and II (TC I and II), each having a specific role and time of function; and (b) by three active transport ...
C. Hall
semanticscholar   +1 more source