Results 331 to 340 of about 373,177 (393)
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Conformation and stability of the anion transport protein of human erythrocyte membranes
Biochemistry, 1985The conformation and stability of purified preparations of band 3, the anion transport protein of human erythrocyte membranes, and its constituent proteolytic subfragments have been studied by circular dichroism. Band 3, purified in the presence of the nonionic detergent n-dodecyl octaethylene glycol monoether (C12E8), had an alpha-helical content of ...
Kimio Oikawa +2 more
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Fluorescent stilbene (BADS) binding proteins in anion-transporting epithelia
American Journal of Physiology-Cell Physiology, 1990Chloride transport occurs at the interface between the internal and external environments of a cell where chloride uptake or efflux is regulated through a variety of mechanisms that involve cotransport of cations, exchange mechanism with anions, or movement through channels.
J. A. Zadunaisky, S. F. A. Pearce
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Denaturation of a membrane transport protein by urea: The erythrocyte anion exchanger
The Journal of Membrane Biology, 1987Chloride equilibrium exchange was measured in the presence of intracellular and extracellular urea, several different alkylureas and thiourea. Urea half-inhibited Cl exchange at about 2.5 M, but the other, less polar analogs had significantly higher potencies; e.g., butylurea half-inhibited at about 60 mM.
Otto Fröhlich, Stephen C. Jones
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The Impact of Plasma Protein Binding on the Renal Transport of Organic Anions
The Journal of Pharmacology and Experimental Therapeutics, 2006Drugs and xenobiotics bind to plasma proteins with varying degrees of affinity, and the amount of binding has a direct effect on free drug concentration and subsequent pharmacokinetics. Multiple active and facilitative transport systems regulate the excretion of anionic compounds from the blood in excretory and barrier tissues.
John B. Pritchard +3 more
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Bicarbonate transport proteins.
Biochemistry and cell biology = Biochimie et biologie cellulaire, 2002Bicarbonate is not freely permeable to membranes. Yet, bicarbonate must be moved across membranes, as part of CO2 metabolism and to regulate cell pH.
D. Sterling, J. Casey
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Drug Metabolism And Disposition, 2004
Dexamethasone (DEX) is a well established inducer of CYP3A. These studies examined the influence of DEX treatment on transport protein expression and function in sandwich-cultured (SC) rat hepatocytes.
R. Turncliff, P. Meier, K. Brouwer
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Dexamethasone (DEX) is a well established inducer of CYP3A. These studies examined the influence of DEX treatment on transport protein expression and function in sandwich-cultured (SC) rat hepatocytes.
R. Turncliff, P. Meier, K. Brouwer
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Anion transport in relation to proteolytic dissection of band 3 protein
Biochimica et Biophysica Acta (BBA) - Biomembranes, 1978Sulfate efflux was measured in inside-out vesicles obtained from human red cells. Inhibition was observed in vesicles derived from cells pretreated with DIDS (4,4'-diisothiocyano-2,2'-stilbene disulfonate) or after addition of dipyridamole to the vesicles, both agents being specific and potent inhibitors of anion transport in cells.
Saul Ship +2 more
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1989
The major 95 kdalton transmembrane protein of the red-cell membrane, denoted band 3 (Fairbanks et al., 1971) or capnophorin (Wieth and Bjerrum, 1983), catalyzes a tightly coupled exchange of anions. The purpose of this chapter is to summarize the current state of knowledge regarding the structure of this protein, with emphasis on those aspects of the ...
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The major 95 kdalton transmembrane protein of the red-cell membrane, denoted band 3 (Fairbanks et al., 1971) or capnophorin (Wieth and Bjerrum, 1983), catalyzes a tightly coupled exchange of anions. The purpose of this chapter is to summarize the current state of knowledge regarding the structure of this protein, with emphasis on those aspects of the ...
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Computational Analysis of Organic Anion Transport Proteins
2020This project will use ancestral sequence reconstruction and computational modeling to inform the design of novel function in human OATP proteins with the dual goal of enhanced uptake of MRI contrast agents and non-immunogenic properties. These new functions will allow cells introduced into the body, such as stem cells or immunotherapies to be ...
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Structure and Function of the Red Blood Cell Anion Transport Protein
Annual Review of Biophysics and Biophysical Chemistry, 1989PHYSIOLOGICAL FUNCTION . Role of Chloride-Bicarbonate Exchange in Carbon Dioxide Transport .. Other Substrates of Red Cell Band 3 . . Transport Functions Other Than Anion Exchange . . Band 3 Homologs in Nonerythroid Cells ..
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