Results 41 to 50 of about 125,986 (267)

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

Condensation and partial pressure change as a major cause of airflow: Experimental evidence

Dyna, 2017
The dominant model of atmospheric circulation is based on the notion that hot air rises, creating horizontal winds. A second major driver has been proposed [1] in the biotic pump theory (BPT), by which intense condensation is the prime cause of surface ...
Peter Paul Bunyard, Martin Hodnett, Carlos Peña, Javier Burgos Salcedo   +3 more
doaj   +1 more source

Paramagnetic Rim Lesions Are Associated With Trans‐Synaptic Degeneration of the Visual Pathway in Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives Retrograde trans‐synaptic degeneration (rTSD) from posterior visual pathway lesions in multiple sclerosis (MS) is characterized by hemi‐macular ganglion cell‐inner plexiform layer (GCIPL) thinning and contralateral visual field loss.
Abdul Jaber Tayem, Angel Liu, Sargis Manukyan, Mustafa Subhi, Elaina Luskin, Bryan Quah, Sreekanth Madhusoodhanan Nair, Arzu C. Has Silemek, Gabriela Zabala, Yujie Cui, Laura Locke, Paula Barreras, Marwa Kaisey, Vinicius Calsavara, Daniel S. Reich, Nancy L. Sicotte, Pascal Sati, Omar Al‐Louzi   +17 more
wiley   +1 more source

Study on Hydraulic Fracture Propagation of Strong Heterogeneous Shale Based on Stress‐Seepage Damage Coupling Model

Energy Science & Engineering
The developed laminar structure of shale makes it possess obvious anisotropic characteristics, and these anisotropic characteristics are one of the important factors leading to the strong and weak heterogeneous properties of shale. Additionally, there is
Wei Liu, Lei Xiao, Yunbin Ke, Yang Zhi, Kangxing Dong   +4 more
doaj   +1 more source

Isotope Effect in the Translation-Invariant Bipolaron Theory of High-Temperature Superconductivity

Condensed Matter, 2020
It is shown that the translation-invariant bipolaron theory of superconductivity can explain the dependence of the isotope coefficient in high-temperature superconductors on the critical temperature of a superconducting transition: in the case of strong ...
Victor D. Lakhno
doaj   +1 more source

A Depolarizing Leak in Sodium Bicarbonate Cotransporter NBCe1 Causes Brain Edema

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives SLC4A4 encodes electrogenic sodium bicarbonate cotransporter NBCe1, prominently expressed in kidney and brain. Recessive loss‐of‐function variants in SLC4A4 cause proximal renal tubular acidosis, no brain edema. In the brain, NBCe1 is expressed by astrocytes, where it regulates pH and mediates astrocyte volume changes.
Quinty Bisseling, Mark D. Parker, Sven Kerst, Richard A. Pasternack, Jacob Tondreau, Marjolein Breur, Gemma M. van Rooijen‐van Leeuwen, Davide Tonduti, Ettore Salsano, Alejandra Darling, Joanna A. E. van Wijk, Susanna Törnroth‐Horsefield, Marianna Bugiani, Petra J. W. Pouwels, Quinten Waisfisz, Marjo S. van der Knaap, Rogier Min   +16 more
wiley   +1 more source

Anisotropic mechanical properties and cushioning effectiveness of spruce subjected to different direction loading

Materials Research Express
The arrayed microstructure of wood produced during growth results in anisotropic mechanical behavior at the macroscopic level. In order to assess the cushioning effectiveness of spruce, the microstructural models with regular hexagonal array cells along ...
Zexiong Zhang, Weizhou Zhong, Jiaxing Li, Jingrun Luo   +3 more
doaj   +1 more source

The effect of a hypocycloid irregularity on torsional surface waves in a multilayer system [PDF]

Theoretical and Applied Mechanics
The present topic is devoted to investigating the effects of semi four-cusped hypocycloid irregularity on torsional surface waves in an initially stressed anisotropic porous medium situated between two anisotropic nonhomogeneous semi-infinite spaces. The
Saha Anup, Das Sandip Kumar
doaj   +1 more source

Free Convection of a Bingham Fluid in a Differentially-Heated Porous Cavity: The Effect of a Square Grid Microstructure

Physics, 2022
We examine how a square-grid microstructure affects the manner in which a Bingham fluid is convected in a sidewall-heated rectangular porous cavity. When the porous microstructure is isotropic, flow arises only when the Darcy–Rayleigh number is higher ...
D. Andrew S. Rees
doaj   +1 more source