Results 161 to 170 of about 77,929 (279)

Impact of Clear Aligners on the Oral Microbiome: A Systematic Review of Current Evidence

open access: yesClinical and Experimental Dental Research, Volume 12, Issue 2, April 2026.
Abstract Objectives Oral malocclusion affects a large portion of the population, impacting both function and aesthetics. Recent advances in orthodontics offer a variety of treatment options, including traditional fixed appliances (FA) and, more recently, clear aligners (CA).
Mariangela Tabone   +4 more
wiley   +1 more source

Distinct Grey Matter Alterations in Untreated Mild to Moderate Chronic Low Back Pain: A Longitudinal Magnetic Resonance Imaging Study

open access: yesEuropean Journal of Pain, Volume 30, Issue 4, April 2026.
ABSTRACT Background Chronic low back pain (CLBP) remains the leading cause of disability worldwide, yet lumbar structural abnormalities seldom account for reported symptoms. Prior neuroimaging studies often report reduced cerebral grey matter density (GMD) in CLBP but typically include patients with moderate‐to‐severe pain who are taking centrally ...
Monica Sean   +8 more
wiley   +1 more source

Therapeutic Decisions in Inflammatory Bowel Disease: ChatGPT‐4.0 Compared to Medical Expertise

open access: yesJGH Open, Volume 10, Issue 4, April 2026.
ABSTRACT Introduction With the increasing prevalence of inflammatory bowel disease (IBD) and its complex management, evaluating innovative approaches became essential. Large language models (LLM), such as ChatGPT‐4.0, have remarkably advanced, yet their application in IBD management remains unexplored.
Helena Loncour   +3 more
wiley   +1 more source

Advances in Crohn's Disease: A Comprehensive Review of Pathophysiology, Diagnosis, and Emerging Therapeutics

open access: yesJGH Open, Volume 10, Issue 4, April 2026.
ABSTRACT Crohn's disease (CD) is a chronic inflammatory condition of the bowel with a rising global incidence. Its complex etiology involves genetic susceptibility, environmental factors, and alterations in the gut microbiota, leading to dysregulated immune responses.
Yoon‐Kyo An   +3 more
wiley   +1 more source

Molecular biology of the HLA-B27 locus [PDF]

open access: yes, 1988
Bloemer, Katharina   +7 more
core   +1 more source

Therapeutic Remodeling of the Gut Microbiome as a Strategy to Restore Immune Tolerance in Autoimmunity

open access: yesMicrobiologyOpen, Volume 15, Issue 2, April 2026.
This graphical abstract illustrates how altered gut microbiota lead to autoimmunity. It shows that gut dysbiosis causes a “leaky gut” and activates autoreactive intestinal immune cells, which then migrate to other organs, ultimately triggering systemic autoimmune responses.
Behshad Boroumand   +9 more
wiley   +1 more source

Immunocompromised Status Definition in Observational Studies Using Electronic Health Records: A Scoping Review and a Proposal for a Phenotype Identification Algorithm

open access: yesPharmacoepidemiology and Drug Safety, Volume 35, Issue 4, April 2026.
ABSTRACT Immunocompromised individuals experience an impaired immune function due to conditions that might be either congenital or acquired over the course of their lives. Epidemiological studies often rely on clinical definitions which, in some cases, benefit from being translated into machine‐readable algorithms for application to electronic health ...
Judit Riera‐Arnau   +62 more
wiley   +1 more source

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