Results 141 to 150 of about 77,929 (279)

BioRePortAP, an electronic clinical record coupled with a database : an example of its use in a single [PDF]

open access: yes, 2010
Aims: To evaluate the efficacy and safety of the treatment of psoriatic arthritis (PsA) patients with tumor necrosis factor (TNF) antagonists in the Rheumatology Department of Hospital de Santa Maria using the BioRePortAP.
Campanilho-Marques, R.   +9 more
core  

Patella baja post tibial plateau levelling osteotomy on a 7‐year‐old Bichon Frise

open access: yesVeterinary Record Case Reports, Volume 14, Issue 2, May 2026.
Abstract A 7‐year‐old, male, neutered Bichon Frise presented with a 3‐month history of intermittent lameness 18 months post tibial plateau levelling osteotomy as treatment for cranial cruciate ligament rupture. On the physical examination, hyperextension of the right stifle joint was detected.
Georgios Vlachomitros   +1 more
wiley   +1 more source

Gender differences in axial spondyloarthritis regarding clinical, radiological characteristics and response to treatment in an Egyptian Cohort Study

open access: yesEgyptian Rheumatology and Rehabilitation
Background Axial spondyloarthritis (axSpA) was thought to be a male disease. Despite that recent data indicated a higher prevalence of female axSpA, female affection is still underrecognized, and more attention to disease characteristics among female ...
Dalia Mohamed Gamal   +4 more
doaj   +1 more source

Against Moral Panic and Citation Fiction: A Critique of “Panem, Corticoids and Circenses” and a Proposal for Editorial Gatekeeping on Reference Integrity

open access: yesBioethics, Volume 40, Issue 4, Page 365-372, May 2026.
ABSTRACT The proposed Enhanced Games have become a convenient stage for bioethical sermonising about risk, authenticity, and the “spirit of sport”. This is epitomized by a recent article arguing that institutionalizing pharmacological enhancement under the “pretence of medical supervision and personal autonomy” would redefine human excellence in ...
Ognjen Arandjelović
wiley   +1 more source

Efficacy and safety of brodalumab in palmoplantar pustulosis: A 68‐week randomized Phase 3 trial

open access: yesJournal of the European Academy of Dermatology and Venereology, Volume 40, Issue 5, Page 887-899, May 2026.
This open‐label study is a continuation of the 16‐week double‐blind, Phase 3 trial assessing the efficacy and safety of brodalumab 210 mg subcutaneously, till a 68‐week extension period. Continued improvement was seen in the PPPASI 50/75/90 responses, PPPSI scores, PGA 0/1 responses and DLQI. Abstract Background The efficacy and safety of brodalumab in
Masamoto Murakami   +6 more
wiley   +1 more source

Rare Gain‐of‐Function Variants in IDH1 and IDH2 Confer Increased Risk of Immune‐Mediated Rheumatic Diseases

open access: yesACR Open Rheumatology, Volume 8, Issue 4, April 2026.
Objective Gain‐of‐function variants in IDH1 and IDH2 are enriched among individuals with coexisting myeloid neoplasms and autoimmune diseases. However, the association between IDH1/IDH2 variants and rheumatic diseases independent of hematologic neoplasms remains unclear. We investigated the association between rare gain‐of‐function and loss‐of‐function
Mahmut S. Kaymakci   +3 more
wiley   +1 more source

Biofabrication of Endothelialized, Intrinsically Vascularized 3D‐Printed Recombinant Spider Silk Scaffolds

open access: yesAdvanced Healthcare Materials, Volume 15, Issue 16, 24 April 2026.
This study evaluates 3D‐printed recombinant spider silk hydrogel eADF4(C16)‐RGD in a rat AV loop model for tissue engineering. Constructs with T17b endothelial progenitor cells showed enhanced vascularization and biodegradation. Results highlight the importance of scaffold design and cellular integration in improving vascular density and overall ...
Claire M. Weinhold   +9 more
wiley   +1 more source

Mechanical Strain‐Programmed SDC1+ Sheath Fibroblasts Trigger CXCR4hi Neutrophil‐Mediated Enthesitis in Ankylosing Spondylitis

open access: yesAdvanced Science, Volume 13, Issue 21, 13 April 2026.
In ankylosing spondylitis (AS), mechanical strain‐programmed SDC1+ sheath fibroblasts secrete CXCL5 to recruit neutrophils and promote the activation of CXCR4hi neutrophils, thereby exacerbating enthesitis by promoting neutrophil extracellular traps (NETs) formation. SOX5 controls the generation of SDC1+ sheath fibroblasts via super‐enhancers.
Jiajie Lin   +13 more
wiley   +1 more source

The 2D:4D Digit Ratio and Primary Sjögren's Syndrome: A Window Into Prenatal Hormonal Influences on Exocrine Autoimmunity

open access: yesAmerican Journal of Human Biology, Volume 38, Issue 4, April 2026.
ABSTRACT Objectives The pronounced female preponderance in Sjögren's syndrome (SS) points to a potential role for sex hormones in disease development. The ratio of the second to fourth digit (2D:4D), which serves as an indirect marker of fetal androgen exposure, has shown associations with several immune‐mediated conditions.
Mustafa Gür   +4 more
wiley   +1 more source

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