Results 1 to 10 of about 1,240 (178)

ANKYRA ÇEVRESİ’DE ROMA DÖNEMİ İZLERİ

Ankara Üniversitesi Dil ve Tarih-Coğrafya Fakültesi Dergisi, 2021
Roma İmparatorluğu’nun Galatia Eyaleti’nin başkenti olan Ankyra, MÖ 25 yılından itibaren bölgenin önemli kentlerinden biri olmuştur. Ankyra kenti üzerine bugüne kadar yapılmış çok sayıda çalışma bulunmaktadır ve bu sayede kentin yapısal, sosyal ve ...
Çiğdem Gençler Güray
doaj   +4 more sources

Interleukin-12 anchored drug conjugate (tolododekin alfa) in patients with advanced solid tumors: first-in-human Phase 1 trial [PDF]

Nature Communications
Anchored immunotherapy is a novel approach for retaining drugs within the tumour microenvironment. Tolododekin alfa is a first-in-class anchored Interleukin 12 (IL-12) linked to aluminum hydroxide. Safety and biological activity were evaluated in a Phase
Jong Chul Park, Brendan Curti, Marcus Butler, Eric Wehrenberg-Klee, Joseph Elassal, Robert Tighe, Sailaja Battula, Gail Iodice, Howard L. Kaufman, John M. Kirkwood   +9 more
doaj   +2 more sources

A phase Ib study of interleukin-2 plus pembrolizumab for patients with advanced melanoma [PDF]

Frontiers in Oncology, 2023
IntroductionHigh-dose interleukin-2 (HD IL-2) and pembrolizumab are each approved as single agents by the U.S. F.D.A. for the treatment of metastatic melanoma. There is limited data using the agents concurrently.
Ann W. Silk, Ann W. Silk, Ann W. Silk, Ann W. Silk, Brendan Curti, Jennifer Bryan, Jennifer Bryan, Tracie Saunders, Weichung Shih, Michael P. Kane, Phoebe Hannon, Christopher Fountain, Jessica Felcher, Andrew Zloza, Andrew Zloza, Andrew Zloza, Howard L. Kaufman, Howard L. Kaufman, Howard L. Kaufman, Howard L. Kaufman, Howard L. Kaufman, Janice M. Mehnert, Janice M. Mehnert, Janice M. Mehnert, David F. McDermott, David F. McDermott   +25 more
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Alum-anchored IL-12 combined with cytotoxic chemotherapy and immune checkpoint blockade enhanced antitumor immune responses in head and neck cancer models [PDF]

Journal for ImmunoTherapy of Cancer
Background First-line treatment with pembrolizumab plus chemotherapy in recurrent and metastatic head and neck squamous cell carcinomas (HNSCC) has improved survival.
James W Hodge, Howard Kaufman, Michelle R Padget, Kellsye P Fabian, Sailaja Battula, Wiem Lassoued, Ginette Santiago-Sanchez, Clint Tanner Allen   +7 more
doaj   +2 more sources

Challenges and opportunities in cancer immunotherapy: a Society for Immunotherapy of Cancer (SITC) strategic vision [PDF]

Journal for ImmunoTherapy of Cancer
Cancer immunotherapy has flourished over the last 10–15 years, transforming the practice of oncology and providing long-term clinical benefit to some patients.
James L Gulley, Deborah Collyar, Pedro J Romero, Christian M Capitini, Leisha A Emens, Avery D Posey, Patrick Hwu, Jennifer A Wargo, Ann W Silk, Ana Carrizosa Anderson   +9 more
doaj   +2 more sources

Advances and challenges in cancer immunoprevention and immune interception [PDF]

Journal for ImmunoTherapy of Cancer
Invasive cancers typically evade immune surveillance through profound local and systemic immunosuppression, preventing their elimination or control. Targeting immune interventions to prevent or intercept premalignant lesions, before significant immune ...
Leisha A Emens, Sasha E Stanton, Philip E Castle, Shizuko Sei, Olivera J Finn   +4 more
doaj   +2 more sources

Updates on radiotherapy-immunotherapy combinations: Proceedings of 8th Annual ImmunoRad Conference [PDF]

OncoImmunology
The annual ImmunoRad Conference has established itself as a recurrent occasion to explore the possibility of combining radiation therapy (RT) and immunotherapy (IT) for clinical cancer management.
Fereshteh Talebi, Fabiana Gregucci, Jalal Ahmed, Nir Ben Chetrit, Brian D. Brown, Timothy A. Chan, Dhan Chand, Julie Constanzo, Sandra Demaria, Dmitry I. Gabrilovich, Encouse Golden, Andrew Godkin, Chandan Guha, Gaorav P. Gupta, Aisha Hasan, Fernanda G. Herrera, Howard Kaufman, Donna Li, Alan A. Melcher, Sierra McDonald, Taha Merghoub, Arta M. Monjazeb, Sébastien Paris, Sean Pitroda, Anguraj Sadanandam, Dörthe Schaue, Laura Santambrogio, Phillippe Szapary, Julien Sage, James W. Welsh, Anna Wilkins, Kristina H. Young, Eric Wennerberg, Laurence Zitvogel, Lorenzo Galluzzi, Eric Deutsch, Silvia C. Formenti   +36 more
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Der Brief der Synode von Ankyra 358 (Dok. 55) [PDF]

, 2017
Untersucht den Brief der Synode von Ankyra (358).
exaly   +3 more sources

Ankyra Tiyatrosu Zırhlı Hadrian Heykeli

Anadolu (Anatolia), 2014
The excavations took place at the Ankyra Roman Theater in 1980's revealed number of sculptural artifacts. Almost all of those aforementioned fragments were found in the nine cells which were connected to each other by window shaped doors in the Theater' Hyposkene section.
exaly   +3 more sources

Talimogene Laherparepvec: Moving From First-In-Class to Best-In-Class

Frontiers in Molecular Biosciences, 2022
Talimogene laherparepvec (T-VEC) is a modified oncolytic herpes Simplex virus, type 1 (HSV-1) encoding granulocyte-macrophage colony stimulating factor (GM-CSF).
Howard L. Kaufman, Howard L. Kaufman, Sophia Z. Shalhout, Gail Iodice   +3 more
doaj   +1 more source