Results 21 to 30 of about 203 (122)

A phase Ib study of interleukin-2 plus pembrolizumab for patients with advanced melanoma

Frontiers in Oncology, 2023
IntroductionHigh-dose interleukin-2 (HD IL-2) and pembrolizumab are each approved as single agents by the U.S. F.D.A. for the treatment of metastatic melanoma. There is limited data using the agents concurrently.
Ann W. Silk, Ann W. Silk, Ann W. Silk, Ann W. Silk, Brendan Curti, Jennifer Bryan, Jennifer Bryan, Tracie Saunders, Weichung Shih, Michael P. Kane, Phoebe Hannon, Christopher Fountain, Jessica Felcher, Andrew Zloza, Andrew Zloza, Andrew Zloza, Howard L. Kaufman, Howard L. Kaufman, Howard L. Kaufman, Howard L. Kaufman, Howard L. Kaufman, Janice M. Mehnert, Janice M. Mehnert, Janice M. Mehnert, David F. McDermott, David F. McDermott   +25 more
doaj   +1 more source

Kościół wobec idolatrii na podstawie dokumentów synodów w latach 50-381

Vox Patrum, 2010
Dieser Aufsatz beschäftigt sich mit dem Thema: Kirche gegen Idolatrie in Acta synodalia in Jahren 50-308. Das Verhältnis der antiken Kirche zum Heidentum wurde schon oft in verschiedenen Publikationen untersucht. Im Rahmen dieses Artikels analisiert der
Michał Kieling
doaj   +1 more source

New Inscriptions from Mysia Abbaeitis

Gephyra
This article presents an epigraphic analysis and historical examination of seven unpublished inscriptions recorded during an archaeological survey of the Simav district of Kütahya province in 2022, 2023 and 2024.
Ahmet Türkan
doaj   +1 more source

Lion Statuette with Male Figure from the Anatolian Civilizations Museum

Ankara Araştırmaları Dergisi
In 25 BC, Amyntas the king of Galatians bequathed his kingdom to the Roman Empire. Galatia became the new province of the Roman Empire and Ancyra served as the capital.
İbrahim Ethem Koçak
doaj   +1 more source

ITS2 data corroborate a monophyletic chlorophycean DO-group (Sphaeropleales)

BMC Evolutionary Biology, 2008
Background Within Chlorophyceae the ITS2 secondary structure shows an unbranched helix I, except for the 'Hydrodictyon' and the 'Scenedesmus' clade having a ramified first helix.
Dandekar Thomas, Ruderisch Benjamin, Förster Frank, Schleicher Tina, Keller Alexander, Müller Tobias, Wolf Matthias   +6 more
doaj   +1 more source

Makedonyalı Büyük İskender'in Ankyra (Ankara) Seferi (MÖ 333): Kullanıldığı Düşünülen Gastronomik Ürünlere Ait Lojistik Bir Değerlendirme

Külliye, 2023
Makedonya kralı Büyük İskender’in doğuya yaptığı seferler sonucunda Gordion şehrine geldiği ve bir süre bölgede ikamet ettiği kaynaklarda yer almaktadır. Bu kadar uzun yürüyüşler içinde tonlarca yükün ordu ile birlikte taşınması çok zorlayıcı, bir yerde olanaksız gözükmektedir.
Tulga ALBUSTANLIOĞLU, İlkay YILMAZ
openaire   +1 more source

Interleukin-12 anchored drug conjugate (tolododekin alfa) in patients with advanced solid tumors: first-in-human Phase 1 trial

Nature Communications
Anchored immunotherapy is a novel approach for retaining drugs within the tumour microenvironment. Tolododekin alfa is a first-in-class anchored Interleukin 12 (IL-12) linked to aluminum hydroxide. Safety and biological activity were evaluated in a Phase
Jong Chul Park, Brendan Curti, Marcus Butler, Eric Wehrenberg-Klee, Joseph Elassal, Robert Tighe, Sailaja Battula, Gail Iodice, Howard L. Kaufman, John M. Kirkwood   +9 more
doaj   +1 more source

The role of cell-surface-bound phosphatases in species competition within natural phytoplankton assemblage: an in situ experiment

Journal of Limnology, 2008
Despite it is widely acknowledged that the ability to hydrolyze dissolved organic matter using extracellular phosphatases is diverse in freshwater phytoplankton, the competition within single species related to presence and quantity of cell-surface-bound
Jaroslav VRBA, Xiuyun CAO, Jiří NEDOMA, Martina ŠTROJSOVÁ, Alena ŠTROJSOVÁ   +4 more
doaj   +1 more source

Real‐World Outcomes of Adjuvant Therapy in Stage III Melanoma and the Impact of Somatic Mutations

Cancer Medicine, Volume 14, Issue 23, December 2025.
ABSTRACT Purpose A significant proportion of patients with locoregional (stage III) cutaneous melanoma recur despite adjuvant systemic therapy. Staging criteria and surgical nodal management have changed since the trials were completed. Data assessing the effect of systemic therapy compared to surveillance are limited, and factors associated with ...
Derek Effiom, Tyler Aprati, Anastasios Karneris, Aleigha Lawless, Tatyana Sharova, Rebecca Johnson, Alexander Menzies, Georgina Long, Benjamin Park, Seungyeon Jung, Douglas Johnson, David Liu, Xue Bai, Keith Flaherty, Ryan Sullivan, Genevieve M. Boland, Sonia Cohen   +16 more
wiley   +1 more source

New Inscriptions from Kalecik/Ankara

Gephyra
In this study, two new inscriptions preserved in the garden of Kalecik Municipality in Kalecik District of Ankara Province are introduced. One of the inscriptions was identified by the Anatolian Civilizations Museum during research conducted in Kalecik ...
Türkan Banu Güler
doaj   +1 more source