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Ankyrin repeats as a dimerization module
Biochemical and Biophysical Research Communications, 2018Legionella pneumophila is a pathogen, causing severe pneumonia in humans called Legionnaires' disease. AnkC (LegA12) is a poorly characterized 495-residue effector protein conserved in multiple Legionella species. Here, we report the crystal structure of a C-terminally truncated AnkC (2-384) at 3.2 Å resolution.
Guennadi Kozlov +8 more
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Where spectrin snuggles with ankyrin
Blood, 2009Using the crystal structure of β-spectrin repeats 14 and 15 that bind ankyrin, together with a crystal structure of a fragment of ankyrin that binds spectrin, and detailed site-directed mutagenesis, Stabach and Ipsaro and their respective colleagues analyze for the first time the structure of the ankyrin-β-spectrin bridge that connects band 3 (AE1) and
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Diversity of ankyrins in the brain
Biochemical Society Transactions, 1991Introduction A major revolution in biology has resulted in the identification and characterization of many of the components of cells at a molecular level. A significant challenge for the future is to determine how these molecules are assembled in cells and, at a higher level of organization, how the molecular ensembles of cells are able to participate
V, Bennett +4 more
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Transient Receptor Potential Ankyrin 1 (TRPA1) Antagonists
Pharmaceutical Patent Analyst, 2015The transient receptor potential ankyrin 1 (TRPA1) channel is an irritant sensor highly expressed on nociceptive neurons. The clinical use of TRPA1 antagonists is based on the concept that TRPA1 is active during disease states like neuropathic pain.
PRETI, Delia +2 more
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Mechanistic studies of ankyrin-B/ankyrin-G autoinhibition and regulation
2015Ankyrins are a family of scaffold proteins, which serves to link great varieties of functional related but structurally diverse integral membrane proteins to the spectrin-based cytoskeletons. In vertebrates, the Ankyrin family consists of three members: ankyrin-R (AnkR), ankyrin-B (AnkB) and ankyrin-G (AnkG), encoded by ANK1, ANK2 and ANK3 ...
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Mechanistic studies of ankyrin autoinhibition and ankyrin-spectrin complex formation
2018Ankyrins coordinate with spectrins in excitable or mechano-resistant tissues/cells to organize various functional membrane domains, and thereby to promote structural stabilities and to regulate physiological activities including fast signaling in heart and brain.
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Ankyrin immunoreactivity in adult rat cerebellum
Neuroscience, 1993An antibody recognizing all ankyrin isoforms was employed to localize ankyrin in the cerebellum by light and electron microscopy. White matter (myelinated fiber tracts) did not contain ankyrin. Granule cell bodies and axons contained ankyrin which extended into the parallel fibers and their synapses.
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Usp9X Controls Ankyrin-Repeat Domain Protein Homeostasis during Dendritic Spine Development
Neuron, 2020Sehyoun Yoon +2 more
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