Results 71 to 80 of about 69,379 (288)

The SET and ankyrin domains of the secreted Legionella pneumophila histone methyltransferase work together to modify host chromatin

mBio, 2023
Legionella pneumophila is a bacterial pathogen ubiquitous in natural and man-made aquatic environments, where it replicates in protozoa. Its intracellular life cycle depends on the establishment of a Legionella-containing vacuole (LCV) where the bacteria
Monica Rolando, Ivy Yeuk Wah Chung, Caishuang Xu, Laura Gomez-Valero, Patrick England, Miroslaw Cygler, Carmen Buchrieser   +6 more
doaj   +1 more source

Tissue-specific Expression of Distinct Spectrin and Ankyrin Transcripts in Erythroid and Nonerythroid Cells [PDF]

, 1985
cDNA probes for three components of the erythroid membrane skeleton, α spectrin, β spectrin, and ankyrin, were obtained by using monospecific antibodies to screen a λgt11 expression vector library containing cDNA prepared from chicken erythroid poly(A)^+
Lazarides, Elias, Moon, Randall T., Ngai, John, Wold, Barbara J.   +3 more
core   +3 more sources

Transient receptor potential Ankyrin 1: structure, function and ligands [PDF]

, 2022
N.V. Pyatigorskaya, O.V. Filippova, N. S. Nikolenko, Aleksey D. Kravchenko   +3 more
openalex   +1 more source

Evolution in Action: Giant Ankyrins Awake [PDF]

Developmental Cell, 2015
Reporting in Developmental Cell, Stephan et al. (2015) demonstrate critical axonal and presynaptic functions from acquisition of an enormous exon by the Drosophila ank2 gene. They propose that highly elongated ank2-XL molecules, associated with the plasma membrane through spectrin and ank2-L, extend deep into the axoplasm to promote microtubule ...
Bennett, Vann, Walder, Kathryn
openaire   +2 more sources

Reduced Dietary Protein Induces Changes in the Dental Proteome

Journal of Experimental Zoology Part B: Molecular and Developmental Evolution, EarlyView.
Low dietary protein (10%) from normal (20%) does change protein expression in tooth proteome and alter developmental pathways. Among the significant protein expressions changes are actin‐based myosins, tooth, and bone development proteins. Perplexingly tooth size is not altered, suggesting more nuanced phenotypic response to low dietary protein in ...
Robert W. Burroughs, Christopher J. Percival, Natasha S. Vitek   +2 more
wiley   +1 more source

The loss of βΙ spectrin alters synaptic size and composition in the ja/ja mouse

Frontiers in Neuroscience
IntroductionDeletion or mutation of members of the spectrin gene family contributes to many neurologic and neuropsychiatric disorders. While each spectrinopathy may generate distinct neuropathology, the study of βΙ spectrin’s role (Sptb) in the brain has
Michael C. Stankewich, Luanne L. Peters, Jon S. Morrow, Jon S. Morrow   +3 more
doaj   +1 more source

LRRK2 as a Potential Disease‐Modifying Target in Sporadic Parkinson's Disease

Movement Disorders, EarlyView.
Abstract A growing understanding of the role that leucine‐rich repeat kinase 2 (LRRK2) plays in Parkinson's disease (PD) supports continued focus on this enzyme as a therapeutic target for PD. Accumulating evidence suggests that there are phenotypic, neuropathologic, and biological similarities between sporadic PD (sPD) and familial forms in which ...
Anthony E. Lang, Robert A. Hauser, Lorraine V. Kalia, Bonnie Hersh, Zdenek Berger, Roy Llorens Arenas, Coro Paisan‐Ruiz, Kyle Fraser, Danna Jennings, Jillian H. Kluss, Sarah Huntwork‐Rodriguez, Anastasia G. Henry, J. Timothy Greenamyre   +12 more
wiley   +1 more source

The diversity and evolution of Wolbachia ankyrin repeat domain genes. [PDF]

PLoS ONE, 2013
Ankyrin repeat domain-encoding genes are common in the eukaryotic and viral domains of life, but they are rare in bacteria, the exception being a few obligate or facultative intracellular Proteobacteria species.
Stefanos Siozios, Panagiotis Ioannidis, Lisa Klasson, Siv G E Andersson, Henk R Braig, Kostas Bourtzis   +5 more
doaj   +1 more source

Differential Proteomics of Large Extracellular Vesicles in Ovarian Cancer

PROTEOMICS, EarlyView.
ABSTRACT Diverse extracellular vesicles (EVs) are present in all body fluids; however, knowledge of large EVs (lEVs) remains limited. Molecular EV profiles vary depending on EV size and the physiological circulatory system, even within the same patient. In this study, we aimed to characterize the proteomic profile of IEVs in ovarian cancer patients and
Kazuhiro Suzuki, Yusuke Yamamoto, Masami Kitagawa, Eri Asano‐Inami, Kosuke Yoshida, Hiroaki Kajiyama, Akira Yokoi   +6 more
wiley   +1 more source

Severe Ankyrin-R deficiency results in impaired surface retention and lysosomal degradation of RhAG in human erythroblasts

Haematologica, 2016
Ankyrin-R provides a key link between band 3 and the spectrin cytoskeleton that helps to maintain the highly specialized erythrocyte biconcave shape.
Timothy J. Satchwell, Amanda J. Bell, Bethan R. Hawley, Stephanie Pellegrin, Kathryn E. Mordue, Cees Th. B. M. van Deursen, Nicole Heitink-ter Braak, Gerwin Huls, Mathie P.G Leers, Eline Overwater, Rienk Y. J. Tamminga, Bert van der Zwaag, Elisa Fermo, Paola Bianchi, Richard van Wijk, Ashley M. Toye   +15 more
doaj   +1 more source