Results 81 to 90 of about 68,407 (296)

The diversity and evolution of Wolbachia ankyrin repeat domain genes. [PDF]

PLoS ONE, 2013
Ankyrin repeat domain-encoding genes are common in the eukaryotic and viral domains of life, but they are rare in bacteria, the exception being a few obligate or facultative intracellular Proteobacteria species.
Stefanos Siozios, Panagiotis Ioannidis, Lisa Klasson, Siv G E Andersson, Henk R Braig, Kostas Bourtzis   +5 more
doaj   +1 more source

Hypermethylated gene ANKDD1A is a candidate tumor suppressor that interacts with FIH1 and decreases HIF1α stability to inhibit cell autophagy in the glioblastoma multiforme hypoxia microenvironment. [PDF]

, 2019
Ectopic epigenetic mechanisms play important roles in facilitating tumorigenesis. Here, we first demonstrated that ANKDD1A is a functional tumor suppressor gene, especially in the hypoxia microenvironment.
Fan, Li, Feng, Jianbo, Fu, Haijuan, Li, Guiyuan, Li, Peiyao, Liu, Changhong, Liu, Qiang, Liu, Qing, Ren, Xing, She, Xiaoling, Sun, Yingnan, Wu, Minghua, Zhang, Yan, Zhao, Chunhua   +13 more
core   +1 more source

Structural and Energetic Characterization of the Ankyrin Repeat Protein Family [PDF]

, 2015
Ankyrin repeat containing proteins are one of the most abundant solenoid folds. Usually implicated in specific protein-protein interactions, these proteins are readily amenable for design, with promising biotechnological and biomedical applications ...
Espada, Rocío, Ferreiro, Diego Ulises, Parra, Rodrigo Gonzalo, Verstraete, Nina   +3 more
core   +1 more source

The 3‐Hit Metabolic Signaling Model for Autism Spectrum Disorder: A Summary

Autism Research, EarlyView.
ABSTRACT Autism spectrum disorder (ASD) is a highly heritable yet environmentally sensitive neurodevelopmental condition whose biological heterogeneity has resisted a unifying causal explanation for over 100 years. The 3‐hit metabolic signaling model proposes that ASD arises from abnormal persistence of an evolutionarily conserved stress‐response ...
Robert K. Naviaux
wiley   +1 more source

Severe Ankyrin-R deficiency results in impaired surface retention and lysosomal degradation of RhAG in human erythroblasts

Haematologica, 2016
Ankyrin-R provides a key link between band 3 and the spectrin cytoskeleton that helps to maintain the highly specialized erythrocyte biconcave shape.
Timothy J. Satchwell, Amanda J. Bell, Bethan R. Hawley, Stephanie Pellegrin, Kathryn E. Mordue, Cees Th. B. M. van Deursen, Nicole Heitink-ter Braak, Gerwin Huls, Mathie P.G Leers, Eline Overwater, Rienk Y. J. Tamminga, Bert van der Zwaag, Elisa Fermo, Paola Bianchi, Richard van Wijk, Ashley M. Toye   +15 more
doaj   +1 more source

The ankyrin repeat domain of the TRPA protein painless is important for thermal nociception but not mechanical nociception. [PDF]

PLoS ONE, 2012
The Drosophila TRPA channel Painless is required for the function of polymodal nociceptors which detect noxious heat and noxious mechanical stimuli. These functions of Painless are reminiscent of mammalian TRPA channels that have also been implicated in ...
Richard Y Hwang, Nancy A Stearns, W Daniel Tracey   +2 more
doaj   +1 more source

Glial ankyrins facilitate paranodal axoglial junction assembly [PDF]

Nature Neuroscience, 2014
Neuron-glia interactions establish functional membrane domains along myelinated axons. These include nodes of Ranvier, paranodal axoglial junctions and juxtaparanodes. Paranodal junctions are the largest vertebrate junctional adhesion complex, and they are essential for rapid saltatory conduction and contribute to assembly and maintenance of nodes ...
Chang, Kae-Jiun, Zollinger, Daniel R, Susuki, Keiichiro, Sherman, Diane L, Makara, Michael A, Brophy, Peter J, Cooper, Edward C, Bennett, Vann, Mohler, Peter J, Rasband, Matthew N   +9 more
openaire   +3 more sources

Transcriptomic signatures reveal systemic adaptations and immune modulation in response to training and competitive racing in horses

Equine Veterinary Journal, EarlyView.
Abstract Background The molecular mechanisms underlying adaptation to physical exertion and racing stress in horses remain incompletely understood. Peripheral blood transcriptomics offers a minimally invasive method to monitor systemic responses to exercise and identify biomarkers of adaptation or overload. Objectives To evaluate transcriptomic changes
Izabela Dąbrowska, Jowita Grzędzicka‐Agko, Paula Kiełbik, Michał Trela, Olga Witkowska‐Piłaszewicz   +4 more
wiley   +1 more source

Determination of Ankyrin Repeats Domain (ANK) of RNASE L Gene in Hepatitis C Patients and its effects on Viral Load

Pakistan Journal of Medicine and Dentistry, 2020
Background: Hepatitis C virus (HCV) is one of the major global causes of death. Different types of gene are involved as Ankyrin repeat domains of RNASE L gene.
Anum Liaquat Ali, Syed M. Zahid Azam, Sikandar Ali, Saba Kamil   +3 more
doaj   +1 more source

Mechanical Unfolding of an Ankyrin Repeat Protein [PDF]

Biophysical Journal, 2010
Ankryin repeat proteins comprise tandem arrays of a 33-residue, predominantly alpha-helical motif that stacks roughly linearly to produce elongated and superhelical structures. They function as scaffolds mediating a diverse range of protein-protein interactions, and some have been proposed to play a role in mechanical signal transduction processes in ...
Serquera D., Lee W., Settanni G., Marszalek P. E., Paci E., Ltzhaki L. S.   +5 more
openaire   +2 more sources