Results 91 to 100 of about 30,181 (241)

Ankyrin repeat domain-encoding genes in the wPip strain of Wolbachia from the Culex pipiens group [PDF]

, 2007
BACKGROUND: Wolbachia are obligate endosymbiotic bacteria maternally transmitted through the egg cytoplasm that are responsible for several reproductive disorders in their insect hosts, such as cytoplasmic incompatibility (CI) in infected mosquitoes ...
Parkhill Julian, Sinkins, Steven P., Thomson Nicholas R, Sanders, Mandy J, Klasson Lisa, Walker, T, Sanders, MJ, Sebaihia, M, Parkhill, J, Sinkins Steven P, Klasson, L, Sanders, Mandy J., Klasson, Lisa, Thompson, Nicholas R., Sinkins, Steven P, Sanders Mandy J, Sebaihia, Mohammed, Sebalhia, Mohammed, Parkhill, Julian, Walker, Thomas, Thomson, Nicholas R, Walker Thomas, Thomson, Nicholas R., Sinkins, SP, Sebaihia Mohammed, Thomson, NR   +25 more
core   +1 more source

Expanded Phenotype Associated With an Intronic PPP1R12A Variant: A Case Report and Literature Review

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Autosomal dominant PPP1R12A‐related genitourinary and/or brain malformation syndrome is a recently described multisystem disorder caused by loss‐of‐function variants in the protein phosphatase 1 regulatory subunit 12a (PPP1R12A) gene. To date, 22 affected individuals have been reported with variable brain malformations and genitourinary ...
Emily M. Bland, Amber Nakar Weinstein, Eric C. Kao, Xiaonan Zhao, Monika Weisz‐Hubshman   +4 more
wiley   +1 more source

Research progress on biomarkers of traumatic brain injury

Animal Models and Experimental Medicine, EarlyView.
Traumatic brain injury: From primary insult to secondary neuroinflammation and degeneration. Abstract Traumatic brain injury (TBI) is a common disorder of the nervous system and has become a leading cause of death and disability worldwide, imposing a substantial burden on patients and their social circles. Its main symptoms include dyskinesia, language
Xuting Shen, Si Cheng, Shuyi Chen, Mengyue Wang, Tangying Li, Weicheng Xu, Yifan Zhang, Ping Yuan, Lei Shi   +8 more
wiley   +1 more source

Developing nodes of Ranvier are defined by ankyrin-G clustering and are independent of paranodal axoglial adhesion [PDF]

Proceedings of the National Academy of Sciences, 2002
Nodes of Ranvier are excitable regions of axonal membranes highly enriched in voltage-gated sodium channels that propagate action potentials. The mechanism of protein clustering at nodes has been a source of controversy. In this study, developmental analysis of nodes of Ranvier in optic nerve axons reveals that early node intermediates are
Scott M, Jenkins, Vann, Bennett
openaire   +2 more sources

A Rare Variant of ANK3 Is Associated With Intracranial Aneurysm

Frontiers in Neurology, 2021
Intracranial aneurysm (IA) is a cerebrovascular disorder in which abnormal dilation of a blood vessel results from weakening of the blood vessel wall. The aneurysm may rupture, leading to subarachnoid hemorrhage with severe outcomes.
Junyu Liu, Xin Liao, Xin Liao, Jilin Zhou, Bingyang Li, Lu Xu, Songlin Liu, Yifeng Li, Dun Yuan, Chongyu Hu, Weixi Jiang, Junxia Yan, Junxia Yan   +12 more
doaj   +1 more source

ANK1 and EPB41 Variants and the Risk of Steroid‐Induced Osteonecrosis

Arthritis &Rheumatology, EarlyView.
Objective Steroid‐induced osteonecrosis of the femoral head (SONFH) is a refractory skeletal disorder influenced by genetic and environmental factors. However, conclusive pathogenic genetic evidence remains elusive due to the limited exploration of rare damaging variants. In this study, we aimed to identify rare variants associated with SONFH.
Shengbao Chen, Xianmin Zhu, Zhongzhong Chen, Wei Chen, Hussam Alkaissi, Zeng Zhang, Yun Gao, Junhui Yin, Xiangtian Yu, Qiong Fu, Youshui Gao, Zhenzhong Zhu, Qianying Cai, Pengwei Zhang, Weibin Chen, Xin Zhao, Xiaojin Wu, Karel Pacak, Dongxu Jin, Chunde Bao, Zhengping Zhuang, Changqing Zhang   +21 more
wiley   +1 more source

Specific ion channels contribute to key elements of pathology during secondary degeneration following neurotrauma

BMC Neuroscience, 2017
Background Following partial injury to the central nervous system, cells beyond the initial injury site undergo secondary degeneration, exacerbating loss of neurons, compact myelin and function.
Ryan L. O’Hare Doig, Wissam Chiha, Marcus K. Giacci, Nathanael J. Yates, Carole A. Bartlett, Nicole M. Smith, Stuart I. Hodgetts, Alan R. Harvey, Melinda Fitzgerald   +8 more
doaj   +1 more source

Understanding the Role of Ankyrin-G in Synaptic Biology [PDF]

, 2019
Ankyrin-G is a fundamental scaffolding protein that organizes neuronal excitable membrane domains, including the axon initial segment (AIS) and nodes of Ranvier.
Nelson, Andrew
core  

Tackling cancer stemness with nanotechnology in the era of precision medicine

BMEMat, EarlyView.
Precise customization of nanoparticles (NPs) enables active targeting of cancer stem cells (CSCs), thereby improving drug delivery and therapeutic efficacy. NP‐based probing enhances CSC detection through imaging and liquid biopsy, whereas diverse therapeutic payloads improve therapeutic outcomes.
Shaolei Guo, Shun Yao, Lihui Meng, Chunyuan Chen, Yuechu Lucinda Lu, Rong Lu, Kashif Rafiq Zahid, Umar Raza, Qingzhi Wu, Wenli Chen   +9 more
wiley   +1 more source

The Ankyrin-B C-terminal Domain Determines Activity of Ankyrin-B/G Chimeras in Rescue of Abnormal Inositol 1,4,5-Trisphosphate and Ryanodine Receptor Distribution in Ankyrin-B (−/−) Neonatal Cardiomyocytes [PDF]

Journal of Biological Chemistry, 2002
Ankyrins are a closely related family of membrane adaptor proteins that are believed to participate in targeting diverse membrane proteins to specialized domains in the plasma membrane and endoplasmic reticulum. This study addresses the question of how individual ankyrin isoforms achieve functional specificity when co-expressed in the same cell ...
Peter J, Mohler, Anthony O, Gramolini, Vann, Bennett   +2 more
openaire   +2 more sources