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The ankyrin repeat: a diversity of interactions on a common structural framework
Trends in Biochemical Sciences, 1999The ankyrin repeat is one of the most common protein sequence motifs. Recent X-ray and NMR structures of ankyrin-repeat proteins and their complexes have provided invaluable insights into the molecular basis of the extraordinary variety of biological activities of these molecules.
Stephen Smerdon
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Stabilizing Ionic Interactions in a Full-consensus Ankyrin Repeat Protein
Journal of Molecular Biology, 2008Full-consensus designed ankyrin repeat proteins (DARPins), in which randomized positions of the previously described DARPin library have been fixed, are characterized. They show exceptionally high thermodynamic stabilities, even when compared to members of consensus DARPin libraries and even more so when compared to naturally occurring ankyrin repeat ...
Peer Mittl +2 more
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Ankyrin repeats as a dimerization module
Biochemical and Biophysical Research Communications, 2018Legionella pneumophila is a pathogen, causing severe pneumonia in humans called Legionnaires' disease. AnkC (LegA12) is a poorly characterized 495-residue effector protein conserved in multiple Legionella species. Here, we report the crystal structure of a C-terminally truncated AnkC (2-384) at 3.2 Å resolution.
Guennadi Kozlov +8 more
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Superfamily of ankyrin repeat proteins in tomato
Gene, 2013The ankyrin repeat (ANK) protein family plays a crucial role in plant growth and development and in response to biotic and abiotic stresses. However, no detailed information concerning this family is available for tomato (Solanum lycopersicum) due to the limited information on whole genome sequences.
Xiaowei, Yuan +7 more
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Two C-terminal ankyrin repeats form the minimal stable unit of the ankyrin repeat protein p18INK4c
Journal of Molecular Modeling, 2008Ankyrin repeat proteins (ARPs) appear to be abundant in organisms from all phyla, and play critical regulatory roles, mediating specific interactions with target biomolecules and thus ordering the sequence of events in diverse cellular processes. ARPs possess a non-globular scaffold consisting of repeating motifs named ankyrin (ANK) repeats, which ...
Petr, Sklenovský +2 more
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Functional role of proteins containing ankyrin repeats
Cell and Tissue Biology, 2008This review describes and discusses new data about the structure and function of proteins which contain ankyrin-like repeats in their structure. These proteins have been found in cells of different organisms but they are not belonging to the cytoskeletal proteins.
D A, Voronin, E V, Kiseleva
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A prediction system for ankyrin repeat domain family
2015Ankyrin Repeat Domain (ARD) is an alpha-solenoid repeat structure formed by cascading a series of ankyrin repeat units. These fundamental repeat units within a structure possess low sequence similarity but high structural conservation. An ARD serves as a protein–protein interaction platform in nature, and it is discovered as an important ...
Teng-Wei Wang +3 more
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Biophysical Characterisation of the Small Ankyrin Repeat Protein Myotrophin
Journal of Molecular Biology, 2007The 118 residue protein myotrophin is composed of four ankyrin repeats that stack linearly to form an elongated, predominantly alpha-helical structure. The protein folds via a two-state mechanism at equilibrium. The free energy change of unfolding in water (DeltaG(U-N)(H(2)O)) is 5.8 kcal.mol(-1).
Alan R, Lowe, Laura S, Itzhaki
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A New Role for Ankyrin Repeats
Science's STKE, 2007Transient receptor potential (TRP) channels are nonselective cation channels that act as sensors of heat and noxious chemicals and thus are important in pain perception. One member of this family, TRPV1, responds to such stimuli as heat, low pH, and capsaicin, the ingredient of chili peppers that makes them "hot." Two mechanisms are known ...
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Designed Ankyrin Repeat Proteins (DARPins)
2012Designed ankyrin repeat proteins (DARPins) have been developed into a robust and versatile scaffold for binding proteins. High-affinity binders are routinely selected by ribosome display and phage display. DARPins have entered clinical trials and have found numerous uses in research, due to their high stability and robust folding, allowing many new ...
Tamaskovic, Rastislav +4 more
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