Results 231 to 240 of about 42,872 (270)

A phase 1b/2 study evaluating efficacy and safety of MP0250, a designed ankyrin repeat protein (DARPin) simultaneously targeting vascular endothelial growth factor (VEGF) and hepatocyte growth factor (HGF), in combination with bortezomib and dexamethasone, in patients with relapsed or refractory multiple myeloma. [PDF]

EJHaem
Knop S, Szarejko M, Grząśko N, Bringhen S, Trautmann-Grill K, Jurczyszyn A, Vacca A, Khandanpour C, Gamberi B, Pour L, Iversen KF, Stumpp MT, Suter C, Dawson KM, Zitt C, Legenne P, Stavropoulou V, Fey MF, Leupin N, Goldschmidt H.   +19 more
europepmc   +1 more source

Nanospring behaviour of ankyrin repeats [PDF]

Nature, 2006
Ankyrin repeats are an amino-acid motif believed to function in protein recognition; they are present in tandem copies in diverse proteins in nearly all phyla. Ankyrin repeats contain antiparallel alpha-helices that can stack to form a superhelical spiral. Visual inspection of the extrapolated structure of 24 ankyrin-R repeats indicates the possibility
Gwangrog Lee, Yong Jiang, Vann Bennett
exaly   +3 more sources

Some of the next articles are maybe not open access.

Related searches:

Ankyrin repeats as a dimerization module

Biochemical and Biophysical Research Communications, 2018
Legionella pneumophila is a pathogen, causing severe pneumonia in humans called Legionnaires' disease. AnkC (LegA12) is a poorly characterized 495-residue effector protein conserved in multiple Legionella species. Here, we report the crystal structure of a C-terminally truncated AnkC (2-384) at 3.2 Å resolution.
Guennadi Kozlov, Kathy Wong, Wenxuan Wang, Pavol Skubák, Juliana Muñoz-Escobar, Yue Liu, Nadeem Siddiqui, Navraj S. Pannu, Kalle Gehring   +8 more
openaire   +2 more sources

Superfamily of ankyrin repeat proteins in tomato

Gene, 2013
The ankyrin repeat (ANK) protein family plays a crucial role in plant growth and development and in response to biotic and abiotic stresses. However, no detailed information concerning this family is available for tomato (Solanum lycopersicum) due to the limited information on whole genome sequences.
Xiaowei, Yuan, Shizhong, Zhang, Xiaohe, Qing, Meihong, Sun, Shiyang, Liu, Hongyan, Su, Huairui, Shu, Xinzheng, Li   +7 more
openaire   +2 more sources

Functional role of proteins containing ankyrin repeats

Cell and Tissue Biology, 2008
This review describes and discusses new data about the structure and function of proteins which contain ankyrin-like repeats in their structure. These proteins have been found in cells of different organisms but they are not belonging to the cytoskeletal proteins.
D A, Voronin, E V, Kiseleva
openaire   +2 more sources

Two C-terminal ankyrin repeats form the minimal stable unit of the ankyrin repeat protein p18INK4c

Journal of Molecular Modeling, 2008
Ankyrin repeat proteins (ARPs) appear to be abundant in organisms from all phyla, and play critical regulatory roles, mediating specific interactions with target biomolecules and thus ordering the sequence of events in diverse cellular processes. ARPs possess a non-globular scaffold consisting of repeating motifs named ankyrin (ANK) repeats, which ...
Petr, Sklenovský, Pavel, Banás, Michal, Otyepka   +2 more
openaire   +2 more sources

Ankyrin Repeat:  A Unique Motif Mediating Protein−Protein Interactions†

Biochemistry, 2006
Ankyrin repeat, one of the most widely existing protein motifs in nature, consists of 30-34 amino acid residues and exclusively functions to mediate protein-protein interactions, some of which are directly involved in the development of human cancer and other diseases.
Junan Li, Anjali Mahajan, Ming-Daw Tsai
exaly   +3 more sources

Development of LRRK2 designed ankyrin-repeat proteins

2023
AbstractLeucine rich repeat kinase 2 (LRRK2) is a large multidomain protein containing two catalytic domains, a kinase and a GTPase, as well protein interactions domains, including a WD40 domain. The association of increased LRRK2 kinase activity with both the familial and sporadic forms of Parkinson’s disease (PD) has led to intense interest in ...
Verena Dederer, Marta Sanz Murillo, Eva P Karasmanis, Kathryn S Hatch, Deep Chatterjee, Franziska Preuss, Kamal R Abdul Azeez, Landon Vu Nguyen, Christian Galicia, Birgit Dreier, Andreas Plückthun, Wim Versees, Sebastian Mathea, Andres E Leschziner, Samara L Reck-Peterson, Stefan Knapp   +15 more
openaire   +1 more source

The ankyrin repeat as molecular architecture for protein recognition [PDF]

Protein Science, 2004
AbstractThe ankyrin repeat is one of the most frequently observed amino acid motifs in protein databases. This protein–protein interaction module is involved in a diverse set of cellular functions, and consequently, defects in ankyrin repeat proteins have been found in a number of human diseases.
Leila K, Mosavi, Tobin J, Cammett, Daniel C, Desrosiers, Zheng-Yu, Peng   +3 more
exaly   +3 more sources

Novel actions of cardiac ankyrin repeat protein

International Congress Series, 2007
Abstract Gene expression profiling of mouse skin wounds has led to the discovery of numerous target genes that may have therapeutic or diagnostic value. Cardiac ankyrin repeat protein (CARP, ankrd1 ) expression is markedly and persistently elevated in cutaneous wounds. This article provides a summary and perspective on CARP with particular reference
Susan E. Samaras, Yubin Shi, Jeffrey M. Davidson   +2 more
openaire   +1 more source