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Ankyrin repeat-containing N-Ank proteins shape cellular membranes
Nature Cell Biology, 2019Cells of multicellular organisms need to adopt specific morphologies. However, the molecular mechanisms bringing about membrane topology changes are far from understood-mainly because knowledge of membrane-shaping proteins that can promote local membrane curvatures is still limited.
Maryam Izadi +2 more
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Biophysical Characterisation of the Small Ankyrin Repeat Protein Myotrophin
Journal of Molecular Biology, 2007The 118 residue protein myotrophin is composed of four ankyrin repeats that stack linearly to form an elongated, predominantly alpha-helical structure. The protein folds via a two-state mechanism at equilibrium. The free energy change of unfolding in water (DeltaG(U-N)(H(2)O)) is 5.8 kcal.mol(-1).
Alan R, Lowe, Laura S, Itzhaki
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A New Role for Ankyrin Repeats
Science's STKE, 2007Transient receptor potential (TRP) channels are nonselective cation channels that act as sensors of heat and noxious chemicals and thus are important in pain perception. One member of this family, TRPV1, responds to such stimuli as heat, low pH, and capsaicin, the ingredient of chili peppers that makes them "hot." Two mechanisms are known ...
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Ankyrin‐repeat proteins from sponge symbionts modulate amoebal phagocytosis
Molecular Ecology, 2013AbstractBacteria–eukaryote symbiosis occurs in all stages of evolution, from simple amoebae to mammals, and from facultative to obligate associations. Sponges are ancient metazoans that form intimate symbiotic interactions with complex communities of bacteria. The basic nutritional requirements of the sponge are in part satisfied by the phagocytosis of
Mary T H D, Nguyen +2 more
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Methyl-Lysine Recognition by Ankyrin-Repeat Proteins
2015The ankyrin repeats (ANKs) of the methyltransferases G9a and GLP bind methyllysine (meK) in a surface aromatic cage. Binding the methylation product with the very same polypeptide that generates it seems essential for some G9a/GLP functions, but it is dispensable for others.
Robert E. Collins, Xiaodong Cheng
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Designed Ankyrin Repeat Proteins as Anti‐Idiotypic‐Binding Molecules
Annals of the New York Academy of Sciences, 2007Abstract: According to the network theory antibodies may act as antigens thus generating anti‐idiotypic antibodies that can function as regulators of immune responses. Designed ankyrin repeat proteins (DARPins) are a new class of binding proteins and may serve as an alternative to antibodies.
Monique, Vogel +6 more
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A membrane-bound ankyrin repeat protein confers race-specific leaf rust disease resistance in wheat
Nature Communications, 2021Markus C Kolodziej +2 more
exaly
Designed Ankyrin Repeat Proteins (DARPins)
2012Tamaskovic, Rastislav +4 more
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